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Low Dose Naltrexone 3mg capsules

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Low Dose Naltrexone 3mg Capsules – Product Information

What is Low Dose Naltrexone (LDN) 3mg?

Low Dose Naltrexone (LDN) 3mg capsules are a lower-dose version of naltrexone, a medication typically used to treat opioid and alcohol dependence. In smaller doses, LDN is believed to help regulate the immune system and reduce inflammation, making it a popular off-label treatment for certain chronic conditions.

What is Low Dose Naltrexone 3mg used for?

LDN 3mg is commonly prescribed off-label to help manage symptoms of:

  • Autoimmune diseases, including multiple sclerosis (MS), lupus, and rheumatoid arthritis
  • Chronic pain conditions, such as fibromyalgia and complex regional pain syndrome
  • Inflammatory bowel diseases, like Crohn’s disease and ulcerative colitis
  • Other conditions involving chronic inflammation or immune system imbalances

How does Low Dose Naltrexone work?

LDN blocks opioid receptors temporarily, encouraging the body to increase endorphin production. Endorphins help regulate immune function and reduce inflammation, which may improve symptoms of pain, fatigue, and immune-related conditions.

How do you take Low Dose Naltrexone 3mg?

  • The usual dose is 3mg once daily, typically taken before bedtime.
  • Doses may vary depending on the condition being treated. Some patients may start at a lower dose and gradually increase under medical supervision.
  • Always follow your doctor’s guidance for the correct dosage.

What are the possible side effects of Low Dose Naltrexone?

Most people tolerate LDN well, but some may experience mild side effects, including:

  • Sleep disturbances, such as vivid dreams or trouble sleeping
  • Digestive discomfort, including nausea or an upset stomach
  • Mild headaches

These effects often subside as the body adjusts to the medication. If symptoms persist, consult a healthcare professional.

Who should not take Low Dose Naltrexone?

LDN is not suitable for individuals who are currently taking opioid medications, as it may block their effects and trigger withdrawal symptoms. You should also:

  • Inform your doctor about any medications or supplements you are taking to avoid interactions.
  • Consult a healthcare professional if you are pregnant or breastfeeding before using LDN.

How should Low Dose Naltrexone 3mg be stored?

  • Keep capsules in a cool, dry place, away from direct sunlight and moisture.
  • Store out of reach of children.

Do I need a consultation before taking Low Dose Naltrexone?

Yes. LDN is a prescription medication, and a consultation with a healthcare provider is required to determine if it is appropriate for your condition.

You can purchase Low Dose Naltrexone 3mg Capsules from courierpharmacy.co.uk after completing an online consultation.

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Low Dose Naltrexone 3mg Capsules – Product Information

What is Low Dose Naltrexone (LDN) 3mg?

Low Dose Naltrexone (LDN) 3mg capsules contain a lower dose of naltrexone, a medication that blocks opioid receptors. While higher doses of naltrexone are used to treat opioid and alcohol dependence, LDN is used in much smaller amounts to help regulate the immune system and reduce inflammation linked to certain chronic conditions.

What is Low Dose Naltrexone 3mg used for?

LDN 3mg capsules are commonly prescribed off-label to help manage symptoms of:

  • Autoimmune diseases, including multiple sclerosis (MS), lupus, and rheumatoid arthritis
  • Chronic pain conditions, such as fibromyalgia and complex regional pain syndrome
  • Inflammatory bowel diseases, like Crohn’s disease and ulcerative colitis
  • Certain cancers, when used alongside conventional treatments
  • Other conditions related to chronic inflammation and immune dysfunction

How does Low Dose Naltrexone work?

LDN temporarily blocks opioid receptors, which encourages the body to increase endorphin production. Endorphins help regulate the immune system and reduce inflammation, which can improve symptoms of pain and autoimmune conditions. By restoring balance to the immune system, LDN may help reduce symptoms and improve overall well-being.

How do you take Low Dose Naltrexone 3mg?

  • The standard dose for LDN is between 1.5mg and 4.5mg, with most people taking 3mg once daily before bed.
  • The best dose varies from person to person, so your doctor may adjust your dosage based on your response.
  • Always follow the instructions provided by your healthcare provider.

What are the possible side effects of Low Dose Naltrexone?

Most people tolerate LDN well, but some may experience mild side effects, including:

  • Sleep disturbances, such as vivid dreams or difficulty falling asleep
  • Digestive issues, including nausea or an upset stomach
  • Mild headaches

These side effects usually improve as the body adjusts to the medication. If symptoms persist or worsen, speak with a healthcare professional.

Who should not take Low Dose Naltrexone?

LDN should not be used by individuals who are currently taking opioid-based medications, as it may block their effects and cause withdrawal symptoms. It is also important to:

  • Inform your doctor of any other medications or supplements you are taking to prevent interactions.
  • Consult a healthcare professional if you are pregnant or breastfeeding before starting LDN.

How should Low Dose Naltrexone 3mg be stored?

  • Keep capsules in a cool, dry place, away from direct sunlight and moisture.
  • Store out of reach of children.

Do I need a consultation before taking Low Dose Naltrexone?

Yes. LDN is a prescription medication, so you must consult a healthcare professional before starting or adjusting your dose. This ensures the treatment is suitable for your specific condition and health needs.

You can purchase Low Dose Naltrexone 3mg Capsules from courierpharmacy.co.uk after completing an online consultation.

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1x 30, 2 x 30, 3 x 30

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Active ingredients

What is it for?

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Warnings and precautions

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Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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What Are Low Dose Naltrexone (LDN) 3mg Capsules?

Low Dose Naltrexone (LDN) 3mg capsules are a lower-dose version of naltrexone, a medication traditionally used in 50mg doses to treat opioid and alcohol addiction. LDN is specially compounded to deliver much smaller doses, typically between 1mg and 4.5mg, for alternative therapeutic purposes.

While higher doses of naltrexone block opioid effects, low doses are believed to regulate the immune system and reduce inflammation. LDN is commonly used off-label for conditions such as fibromyalgia, multiple sclerosis, Crohn’s disease, and other autoimmune or chronic pain disorders.

LDN is usually taken once a day and has gained attention for its potential to support symptom management in a variety of inflammatory and immune-related conditions. However, it is important to note that LDN is not yet officially approved for these uses and is prescribed off-label.

What Is the Active Ingredient in Low Dose Naltrexone (LDN) 3mg Capsules?

The active ingredient in Low Dose Naltrexone (LDN) 3mg capsules is naltrexone hydrochloride (3mg).

Naltrexone is a medication originally developed to treat opioid and alcohol dependence at much higher doses (typically 50mg). However, in smaller doses ranging from 1mg to 4.5mg, it is believed to help regulate the immune system and reduce inflammation. This makes LDN a potential treatment option for various autoimmune and chronic pain conditions, although it is prescribed off-label for these uses.

What Are Low Dose Naltrexone (LDN) 3mg Capsules Used For?

Low Dose Naltrexone (LDN) 3mg capsules are prescribed off-label to help manage a range of chronic and inflammatory conditions. Some of the common uses include:

Autoimmune Conditions

LDN is believed to support the immune system and reduce inflammation, making it a potential treatment for autoimmune diseases such as:

  • Multiple sclerosis (MS)
  • Rheumatoid arthritis
  • Lupus
  • Hashimoto’s thyroiditis

Chronic Pain Conditions

LDN is sometimes used to help with pain relief and inflammation in long-term pain disorders, including:

  • Fibromyalgia
  • Complex regional pain syndrome (CRPS)

Digestive & Inflammatory Bowel Disorders

LDN has shown promise in reducing gut inflammation and managing symptoms of conditions like:

  • Crohn’s disease
  • Ulcerative colitis
  • Irritable bowel syndrome (IBS)

Cancer Support

Some patients take LDN alongside conventional cancer treatments, as it may help boost the immune system. However, more research is needed in this area.

Neurological Conditions

LDN is being studied for its potential role in conditions affecting the brain and nervous system, such as:

  • Parkinson’s disease
  • Alzheimer’s disease

Since LDN is not yet widely approved for these uses, it is important to speak with a healthcare provider before starting treatment to assess whether it is suitable for your condition.

How Do Low Dose Naltrexone (LDN) 3mg Capsules Work?

Low Dose Naltrexone (LDN) 3mg capsules work differently from the standard 50mg dose used to treat opioid addiction. While high-dose naltrexone completely blocks opioid receptors, low doses (between 0.1mg and 4.5mg) only partially block them. This partial effect encourages the body to increase natural endorphin production, which may help relieve pain and regulate the immune system.

How LDN Works

  • Endorphin Boost: By slightly blocking opioid receptors, LDN signals the body to produce more endorphins, which are natural painkillers. This process can help manage chronic pain and balance the immune system, which is useful in autoimmune conditions.
  • Immune System Regulation: LDN is believed to help control inflammation and support immune function, making it a potential treatment option for conditions like autoimmune diseases and chronic pain disorders.

How LDN Affects the Immune System

  • Toll-Like Receptors (TLRs) and Inflammation: These receptors play a role in the body’s immune response to infections. When overactive, they can cause excessive inflammation, which can worsen autoimmune and chronic pain conditions.
  • LDN and TLR4 Blocking: LDN may help reduce unnecessary inflammation by partially blocking TLR4 receptors, helping to calm the immune system. This action is thought to make LDN beneficial for managing chronic pain, autoimmune diseases, and inflammation-related conditions.

Additional Benefits of LDN

  • Dual-Action Effects: Naltrexone exists in two forms—levo-naltrexone, which boosts endorphins, and dextro-naltrexone, which may help reduce inflammation.
  • Pain and Inflammation Control: LDN’s unique ability to affect both opioid receptors and the immune system makes it a potential treatment for conditions involving chronic pain, inflammation, and immune system imbalances.

In summary, LDN 3mg capsules provide a unique way to manage pain and regulate immune function, offering potential benefits for conditions such as chronic pain, autoimmune disorders, and inflammatory diseases.

How to Take Low Dose Naltrexone (LDN) 3mg Capsules

To get the best results from Low Dose Naltrexone (LDN) 3mg capsules, follow these general guidelines:

Dosage Instructions

  • Standard Dose – Take one 3mg capsule daily, preferably before bedtime. This timing helps align with the body's natural cycles to maximise endorphin production.
  • Consistency – Try to take the capsule at the same time every day to maintain steady levels in your system.
  • Food Considerations – LDN can be taken with or without food, but sticking to the same routine each day can help with adherence.
  • Swallowing – Swallow the capsule whole with a glass of water. Do not crush or chew it.
  • Alternative Timing – If taking LDN at night affects your sleep, your healthcare provider may recommend switching to a morning dose.

Always follow the specific instructions given by your healthcare provider, as they may adjust the dose or timing based on your individual needs and condition.

Who Should Not Use Low Dose Naltrexone (LDN)?

Opiate Use and LDN

  • Do not take Low Dose Naltrexone (LDN) 3mg capsules if you are currently using opiates. This medication can block some of the effects of opiates, but taking high doses of opiates while on LDN can cause serious breathing difficulties and circulatory problems, increasing the risk of opiate poisoning.
  • If you are dependent on opiates, do not start LDN, as it can trigger severe withdrawal symptoms.
  • If you require emergency surgery or anaesthesia, make sure your healthcare provider is aware that you are taking LDN. Non-opiate-based anaesthetics should be used where possible. If opioid-based anaesthesia is necessary, a higher dose may be required, but this increases the risk of breathing and circulatory problems.
  • Do not try to override the blocking effects of LDN by taking high doses of opiates. If opiates remain in your system after the naltrexone has worn off, there is a risk of unintentional overdose, which could be life-threatening.

Liver and Kidney Health

  • LDN is metabolised by the liver and kidneys, so if you have any liver conditions, your doctor may need to monitor your liver function before and during treatment.

Other Medications and Low Dose Naltrexone

  • Inform your doctor if you are taking, have recently taken, or plan to take any other medications, including over-the-counter treatments.
  • Many common medicines contain opiates and may not work properly while you are using Low Dose Naltrexone.
  • Some cough syrups, painkillers, and medications for diarrhoea contain opioids and should not be taken while using LDN. Always check with your doctor or pharmacist before taking any new medication.
  • In emergency situations where opioid pain relief is needed, a higher dose may be required. However, this must be done under strict medical supervision, as breathing difficulties and other side effects could be more intense and last longer than usual.

Pregnancy and Breastfeeding

  • If you are pregnant, breastfeeding, or planning to become pregnant, speak with your doctor or pharmacist before taking Low Dose Naltrexone 3mg capsules.
  • LDN should only be used during pregnancy if the potential benefits outweigh any possible risks to the baby.
  • Breastfeeding is not recommended while taking LDN, as it is unclear whether the medication passes into breast milk.

Driving and Operating Machinery

  • Low Dose Naltrexone may cause drowsiness or reduce alertness in some people.
  • If you feel tired, dizzy, or unable to concentrate, avoid driving or using heavy machinery.

What Are the Side Effects of Low Dose Naltrexone (LDN) 3mg Capsules?

Low Dose Naltrexone (LDN) 3mg capsules are generally well tolerated, but like all medications, they may cause some side effects. These effects are usually mild and tend to improve as the body adjusts to the treatment.

Common Side Effects:

  • Sleep Issues: Some people experience vivid dreams or difficulty sleeping, especially when first starting LDN.
  • Digestive Discomfort: Mild nausea, constipation, or diarrhoea may occur, particularly in the early days of treatment.
  • Fatigue: A feeling of tiredness or drowsiness may develop in some users.
  • Headaches: Some individuals report mild to moderate headaches as a temporary side effect.
  • Mood Changes: Occasional mood swings or a slight euphoria may be noticed.
  • Muscle or Joint Pain: Some users may experience mild aches in the muscles or joints.

These side effects are typically short-lived and reduce over time as your body gets used to the medication. If any side effects persist or become bothersome, consult your doctor or pharmacist for advice.

Does Low Dose Naltrexone (LDN) 3mg Capsules Interact with Other Medicines?

Before taking Low Dose Naltrexone (LDN) 3mg capsules, inform your doctor or pharmacist if you are using, have recently used, or plan to take any other medications, including over-the-counter products.

Opioid Medications and LDN

  • LDN blocks opioid receptors, meaning opioid-based medications may not work effectively while you are taking it.
  • If you need cough syrups, diarrhoea medication, or pain relief, check with your doctor first, as these may contain opioids.

Emergency Pain Management

  • If opioid-based painkillers are required in an emergency, higher doses than usual may be necessary for effective pain relief.
  • Close medical supervision is essential to manage potential risks, including respiratory depression or prolonged side effects.

Always discuss your current medications with your doctor or pharmacist before starting LDN to ensure it is safe and suitable for you.

Low Dose Naltrexone (LDN) 3mg Capsules FAQs

What is Low Dose Naltrexone (LDN)?

Low Dose Naltrexone (LDN) is a lower-dose version of naltrexone, typically ranging from 0.5mg to 4.5mg. It is used off-label to help manage conditions related to chronic pain, autoimmune disorders, and immune system regulation. LDN is believed to support the body's natural endorphin production while reducing inflammation.

How does LDN work?

LDN temporarily blocks opioid receptors, triggering the body to produce more endorphins, which are natural pain-relieving chemicals. It also plays a role in immune system modulation, helping to regulate inflammation and improve immune responses in conditions linked to chronic inflammation or immune dysfunction.

What conditions is LDN used for?

LDN is commonly used to help manage:

  • Autoimmune diseases – Multiple sclerosis (MS), lupus, rheumatoid arthritis, Hashimoto’s thyroiditis
  • Chronic pain disorders – Fibromyalgia, complex regional pain syndrome (CRPS)
  • Inflammatory bowel diseases – Crohn’s disease, ulcerative colitis
  • Neurological conditions – Parkinson’s disease, Alzheimer’s disease
  • Cancer support therapy – Used as a complementary treatment in some cases

How do I take Low Dose Naltrexone (LDN) 3mg capsules?

  • Standard dosage: LDN is typically taken once daily, often at bedtime.
  • Adjustments: If it disrupts sleep, some people take it in the morning instead.
  • Consistency: Take it at the same time each day to maintain steady levels in the body.
  • With or without food: It can be taken with or without food, depending on personal preference.

What are the common side effects of LDN?

While LDN is generally well-tolerated, some users may experience:

  • Sleep disturbances – Vivid dreams, insomnia
  • Digestive issues – Nausea, constipation, or diarrhoea
  • Mild headaches
  • Fatigue or mood changes – Temporary feelings of tiredness or emotional shifts

These side effects often improve within a few days to weeks as the body adjusts.

Can LDN be taken with other medications?

LDN is usually safe to take with most medications, but it is important to inform your doctor about any medicines you are using, especially:

  • Opioid-based painkillers – LDN may reduce their effectiveness.
  • Immune-modulating drugs – It may alter their effects, so medical supervision is advised.

Is LDN safe for long-term use?

Yes, LDN is generally safe for long-term use. However, regular check-ups with your doctor are recommended to monitor any changes in symptoms or side effects.

Can I take LDN if I am pregnant or breastfeeding?

  • LDN should only be used during pregnancy or breastfeeding if recommended by a healthcare provider.
  • There is limited research on its safety in these situations, so consulting a doctor is essential before use.

Will stopping LDN cause withdrawal symptoms?

Unlike higher doses of naltrexone used for addiction treatment, LDN is unlikely to cause withdrawal symptoms. However, stopping it suddenly should still be done under medical guidance to ensure a smooth transition.

How long does it take for LDN to start working?

  • Some people notice improvements within a few days, while for others, it may take several weeks or months.
  • The effects of LDN build up over time, so patience is required to see full benefits.

If you have any further questions or need advice, speak to a healthcare provider or pharmacist before starting LDN.

Download patient leaflet

low dose naltrexone 4.5mg capsules courierpharmacy.co.uk

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Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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