Colchicine tablets are an effective treatment for acute gout attacks, reducing inflammation and pain caused by uric acid crystals in the joints [1]. They work quickly and are best taken at the first sign of symptoms [2].
Available online for acute attacks of gout (12 tablets supplied).
Colchicine tablets are a prescription-only medication widely used to treat and prevent gout attacks. They belong to a group of medicines called anti-inflammatories, which work by reducing the inflammation caused by uric acid crystals that accumulate in the joints. This inflammation is the leading cause of the intense pain and swelling experienced during a gout flare [1]. The tablets are fast-acting, often starting to work within 30 minutes to 2 hours after taking them [2]. Many patients notice a significant reduction in pain and swelling within 24 hours. Colchicine tablets are best taken at the first sign of a gout attack to maximise their effectiveness [3].
Rapid relief of gout symptoms
Easy-to-take oral tablets
Suitable for short-term use during acute attacks
Available in generic forms that are affordable and effective
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Your complete guide to colchicine tablets for gout treatment at courierpharmacy.co.uk
Relieves pain by reducing inflammation
Starts working within 30 minutes to 2 hours
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Don’t let gout slow you down. Colchicine tablets help reduce inflammation and ease swelling, allowing you to return to feeling like yourself.
Overview: key takeaways about colchicine tablets
Colchicine tablets quickly reduce inflammation caused by gout attacks [1].
They work best when taken early, at the first sign of a flare [2].
The medication is prescription-only and must be used carefully to avoid side effects [3].
Colchicine is not a painkiller but an anti-inflammatory that targets the cause of gout pain [1].
Proper dosing and medical supervision are essential for safe and effective treatment [2].
Colchicine tablets have been trusted for centuries, originally derived from the autumn crocus plant. Today, they remain a cornerstone in managing gout, providing relief to many people from painful flare-ups and improving their quality of life [3].
Active ingredient
The active ingredient in colchicine tablets is colchicine itself, a natural alkaloid extracted from the Colchicum autumnale plant, commonly known as the autumn crocus [2]. Colchicine works by interfering with the movement and function of white blood cells, reducing the inflammatory response triggered by uric acid crystals in the joints [3].
What are colchicine tablets for?
Colchicine tablets are prescribed primarily to treat acute gout attacks—sudden episodes of severe joint pain and swelling caused by uric acid crystal build-up [1]. They may also be used to prevent gout flares when starting long-term uric acid-lowering treatments, such as allopurinol or febuxostat [3].
Beyond gout, colchicine has applications in other inflammatory conditions; however, its primary use in the UK is for effectively managing gout symptoms [2].
How do colchicine tablets work?
Colchicine reduces inflammation by blocking the activity and movement of neutrophils, a type of white blood cell involved in the immune response [1].
When uric acid crystals form in a joint, neutrophils rush to the area and release substances that cause swelling, redness, and pain [3].
By stopping neutrophils from gathering and releasing these chemicals, colchicine calms the inflammation and eases symptoms [2]. It also interferes with the activation of specific inflammatory pathways, including the NLRP3 inflammasome, which plays a key role in gout flare-ups [1].
Unlike painkillers, colchicine targets the root cause of gout inflammation rather than just masking pain, making it a valuable treatment when used early during a flare [3].
How to use colchicine tablets
Take colchicine tablets exactly as prescribed by your doctor. They are usually taken orally with water and should not be crushed or split, as this can affect how the medicine is absorbed [2].
For acute gout attacks, start taking colchicine as soon as you notice symptoms, such as joint pain or swelling [1]. Follow the dosing schedule carefully, typically one tablet two to four times a day, but do not exceed the maximum total dose of 6 mg per attack [3].
If you miss a dose, take it as soon as you remember unless it’s nearly time for your next dose. Never double up doses to make up for a missed one [2].
Warnings and precautions
Colchicine has a narrow safety margin, so it’s essential to take the correct dose and avoid overdosing, which can be dangerous [3]. It should not be used by people allergic to colchicine or with certain health conditions, such as severe kidney or liver problems [2].
Avoid grapefruit and grapefruit juice while taking colchicine, as these can increase the medicine’s level in your blood and raise the risk of side effects [1].
Inform your doctor about all other medications you take to avoid potential harmful interactions, especially with antibiotics, antifungals, and certain heart medications [3].
If you experience symptoms like severe nausea, vomiting, diarrhoea, muscle pain, or unexplained bruising, stop taking colchicine and seek medical help immediately [2].
Side effects
Common side effects include nausea, vomiting, stomach pain, and diarrhoea [2]. These may be signs of colchicine toxicity and should be reported to your doctor promptly [3]. Rare but serious side effects include blood disorders, muscle damage, allergic reactions, and nerve inflammation. Immediate medical attention is required if you experience fever, mouth ulcers, unexplained bleeding, or severe skin reactions [1].
Drug interactions
Colchicine interacts with several medicines that can increase its levels in the body, including:
Certain antibiotics (clarithromycin, erythromycin) [3]
These interactions can lead to serious side effects; therefore, always inform your healthcare provider about all medications and supplements you use [1].
FAQ
What are colchicine tablets used for?
Colchicine tablets treat and prevent gout attacks by reducing inflammation caused by uric acid crystals in the joints [1].
How quickly do colchicine tablets work?
They usually start working within 30 minutes to 2 hours, but full relief may take up to 24 hours [2].
Can I take colchicine tablets long-term?
Colchicine is primarily used for short-term treatment during acute attacks or as a preventive measure at low doses when starting other gout medications [3].
What if I miss a dose?
Please take it as soon as you remember, unless it’s close to your next dose. Don’t double up [2].
Can I drink alcohol while taking colchicine?
It’s best to limit alcohol, as it can increase gout risk and may worsen side effects [1].
Are there any foods I should avoid?
Avoid grapefruit and grapefruit juice while taking colchicine [3].
Can colchicine cause side effects?
Yes, common ones include stomach upset and diarrhoea. Serious side effects need urgent medical care [2].
Is colchicine safe during pregnancy?
Colchicine is generally not recommended during pregnancy unless advised by a doctor [1].
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