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Sildenafil 50mg Tablets

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Sildenafil 50mg Tablets Overview

Mechanism of Action

Sildenafil 50mg tablets are a common treatment for erectile dysfunction (ED) in men. They work by blocking the enzyme phosphodiesterase type 5 (PDE5), which normally breaks down cGMP. By inhibiting PDE5, sildenafil improves blood flow to the penis during sexual stimulation, making it easier to achieve and sustain an erection.

Usage Instructions

  • Often recommended for men new to sildenafil treatment, those with underlying health conditions, or individuals on other medications that might interact with higher doses.
  • Take one tablet approximately 30 to 60 minutes before sexual activity.
  • The effects can last for up to four hours.
  • Always use under the guidance of a healthcare professional to ensure safety and effectiveness.

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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What are Sildenafil 50mg Tablets?

Overview

Sildenafil 50mg tablets are prescribed to treat erectile dysfunction (ED) in men. They work by blocking the enzyme phosphodiesterase type 5 (PDE5), which increases blood flow to the penis during sexual arousal, helping to achieve and maintain an erection.

Dosage and Usage

This dosage is often advised for men who are new to sildenafil, have certain health conditions, or are taking other medications that might interact with higher doses. Typically, you should take one tablet about 30 to 60 minutes before sexual activity, and the effects can last up to four hours.

Safety

As with all medications, it is essential to use Sildenafil 50mg tablets under the supervision of a healthcare professional to ensure safety and effectiveness.

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Active Ingredient in Sildenafil 50mg Tablets

Key Component

Each tablet contains 25mg of sildenafil citrate.

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What are Sildenafil 50mg Tablets Used For?

Purpose and Function

Sildenafil 50mg tablets, available both as the branded version of Viagra and as a generic alternative, are prescribed for treating erectile dysfunction in men. The active ingredient, sildenafil citrate, is a phosphodiesterase-5 (PDE-5) inhibitor.

How It Works

Sildenafil works by blocking the PDE-5 enzyme, which normally breaks down cyclic guanosine monophosphate (cGMP). By maintaining cGMP levels, the medication helps keep the smooth muscles relaxed and the blood vessels dilated in the penis, thus promoting increased blood flow and enabling an erection during sexual stimulation.

Usage Guidelines

  • Taken orally as needed, typically about one hour before sexual activity.
  • Can be taken with or without food.

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How Do Sildenafil 50mg Tablets Work?

Mechanism of Action

Sildenafil 50mg is a selective inhibitor of phosphodiesterase type 5 (PDE5). It works by blocking this enzyme, which normally breaks down nitric oxide (NO) released during sexual arousal.

Erection Process

By inhibiting PDE5, sildenafil boosts the levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. The increased cGMP relaxes the smooth muscles and dilates the blood vessels in the penis, allowing more blood to flow in and facilitating an erection.

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How to Use Sildenafil 50mg Tablets?

Dosage and Administration

The advised dose is sildenafil 50mg taken on an as-needed basis, about 30 to 60 minutes prior to sexual activity.

Food Considerations

These tablets may be consumed with or without food; however, a meal high in fat could delay their onset of action.

Dosing Frequency

It is recommended to take no more than one dose per day.

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Who Cannot Take Sildenafil 50mg Tablets?

Suitability Assessment

Sildenafil 50mg tablets are prescribed for treating erectile dysfunction in men. Before prescribing, healthcare providers evaluate a patient’s suitability using a questionnaire or consultation. Certain conditions may require further assessment or may render these tablets inappropriate.

Conditions to Consider

Men with the following conditions should avoid taking Sildenafil 50mg tablets without additional evaluation by their primary care doctor:

  • Using nitrate medications (commonly prescribed for chest pain)
  • Taking or planning to use amyl nitrite ("poppers")
  • Using riociguat (a drug for high blood pressure in the lungs)
  • Experiencing either low or high blood pressure
  • Having allergies or previous adverse reactions to other ED treatments
  • Recent heart attack (within the past six weeks), angina, or other heart conditions
  • A history of strokes or transient ischemic attacks (mini-strokes)
  • Past vision problems related to circulation issues
  • A family history of rare degenerative eye diseases
  • Serious kidney or liver disease
  • Peyronie’s disease (curvature or deformity of the penis)
  • Conditions such as leukemia, multiple myeloma, or sickle cell disease
  • Bleeding disorders like hemophilia
  • Active stomach ulcers (peptic or gastric ulcers)
  • Lactose intolerance, since these tablets contain lactose

Drug Interaction Warnings

There is a rare risk of abnormal heart rhythm when Sildenafil 50mg tablets are taken with certain other medications. Always discuss potential drug interactions with your healthcare provider.

Contraindications

These tablets should not be used by patients with a known hypersensitivity to sildenafil or any of its excipients. They are also contraindicated for patients using nitrates or nitric oxide donors, as combining these can lead to a dangerous drop in blood pressure.

Precautions Before Use

Prior to starting sildenafil treatment, a complete medical history and physical examination should be performed to diagnose erectile dysfunction and identify any underlying causes. Special caution is advised for patients with cardiovascular disease, anatomical penile deformities, or a tendency toward priapism. Patients should seek immediate medical help if an erection lasts longer than four hours.

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Side Effects of Sildenafil 50mg Tablets

General Tolerance and Common Side Effects

Sildenafil 50mg tablets are typically well tolerated by most users, with only a few mild side effects. They work by increasing blood flow, which can sometimes cause minor effects in other parts of the body. Most users continue taking the medication without any issues.

  • Common side effects include headache, facial flushing, indigestion, visual disturbances, nasal congestion, and dizziness.
  • These effects are usually manageable with simple remedies or over-the-counter medications.

Rare but Serious Side Effects

In uncommon cases, more serious reactions may occur, such as:

  • Chest pain, which might signal a heart attack
  • Sudden loss of vision
  • A prolonged, painful erection (priapism), which requires immediate medical attention as it can lead to permanent damage

Patient Information and Consultation

The complete list of side effects is provided in the patient information leaflet that accompanies your medication. It is important to read this leaflet thoroughly and discuss any concerns with your healthcare provider.

Drug Interactions

Sildenafil 50mg tablets may interact with other medications, potentially increasing the risk of side effects. Always inform your doctor about all prescription, over-the-counter drugs, and supplements you are taking.

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Drug Interactions with Sildenafil 50mg Tablets

Overview

Sildenafil 50mg tablets are used to treat erectile dysfunction but can interact with various medications. These interactions may alter the effectiveness of sildenafil or increase the risk of side effects. It is important to tell your healthcare provider about every medicine you take, including prescription drugs, over-the-counter products, and herbal supplements.

Interactions with Specific Medications

  • Nitrate Medications

    • Examples: Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate
    • Effect: Can cause a dangerous drop in blood pressure
    • Advice: Avoid using sildenafil with any nitrate medications.
  • Alpha-Blockers

    • Examples: Doxazosin, tamsulosin
    • Effect: May lead to a significant blood pressure drop, causing dizziness or fainting
    • Advice: Use these only under strict medical supervision.
  • Antihypertensives

    • Examples: Amlodipine, enalapril
    • Effect: They can enhance blood pressure-lowering effects, increasing the risk of hypotension
    • Advice: Regular blood pressure monitoring is advised.
  • Protease Inhibitors (for HIV)

    • Examples: Ritonavir, saquinavir
    • Effect: May raise sildenafil levels in the blood, heightening side effects
    • Advice: A dosage adjustment of sildenafil may be necessary.
  • Antifungal Medications

    • Examples: Ketoconazole, itraconazole
    • Effect: Can increase sildenafil concentrations in the bloodstream
    • Advice: Your doctor may adjust your sildenafil dose.
  • Antibiotics

    • Examples: Erythromycin, clarithromycin
    • Effect: They can boost plasma levels of sildenafil, increasing side effects
    • Advice: Consult your healthcare provider for potential dose adjustments.
  • Rifampin (for tuberculosis)

    • Effect: Speeds up sildenafil metabolism, reducing its effectiveness
    • Advice: A higher dose of sildenafil might be required.
  • Other ED Medications

    • Examples: Tadalafil, vardenafil
    • Effect: Combining these with sildenafil can raise the risk of severe side effects, such as priapism
    • Advice: Do not mix erectile dysfunction treatments without medical advice.
  • Grapefruit Juice

    • Effect: Increases blood levels of sildenafil, intensifying its effects and side effects
    • Advice: Avoid consuming grapefruit juice while taking sildenafil.
  • Alcohol

    • Effect: May worsen side effects like dizziness and further lower blood pressure
    • Advice: Limit alcohol intake when using sildenafil.

Special Considerations

Older adults and individuals with certain health conditions may be more sensitive to these interactions. Always discuss your complete medical history with your healthcare provider. Regular monitoring is recommended when using sildenafil alongside other medications. If you experience severe side effects, such as chest pain, extreme dizziness, or an erection lasting more than four hours, seek immediate medical attention.

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FAQs about Sildenafil 50mg Tablets

Why Do Men Experience Erectile Dysfunction?

Erectile dysfunction (ED), often known as impotence, is a common issue in men. Its causes can be grouped into three main categories:

  • Physical Causes: Conditions such as cardiovascular diseases (for example, atherosclerosis, high blood pressure, and heart disease) reduce blood flow to the penis. Diabetes, which damages blood vessels and nerves, obesity, hormonal imbalances like low testosterone, and neurological disorders (such as Parkinson's disease, multiple sclerosis, or spinal injuries) can also lead to ED. Some medications, including those for high blood pressure and depression, may trigger ED.
  • Psychological Causes: High stress, anxiety, and depression can impair sexual performance. Relationship issues like poor communication and unresolved conflicts may further contribute.
  • Lifestyle Factors: Smoking, excessive alcohol consumption, recreational drug use, and a lack of physical activity can all adversely affect sexual function.

If you're experiencing ED, speak with your primary care doctor. They can perform an evaluation, run necessary tests, and recommend the best treatment plan for you.

Do Sildenafil 50mg Tablets Work Every Time?

It is suggested to try Sildenafil 50mg tablets at least four times to judge their effectiveness for ED before considering a dosage change or switching treatments. Note that:

  • ED medications might not work for everyone or in every situation.
  • Successful erections depend on factors like proper blood flow, sufficient arousal, and a healthy nervous system.
  • In cases where nerve damage exists from injury or surgery, these tablets may provide only partial relief, and alternative treatments like injections or implants might be necessary.
  • Counseling may also be beneficial for ED caused by psychological factors.

Collaborate with your healthcare provider to pinpoint the cause of your ED and choose the most appropriate treatment.

What Are Sildenafil 50mg Tablets Used For?

Sildenafil 50mg tablets are prescribed to treat erectile dysfunction in men. They work by increasing blood flow to the penis during sexual stimulation, helping you achieve and maintain an erection.

How Should I Take Sildenafil 50mg Tablets?

Take one tablet about one hour before sexual activity. Swallow the tablet whole with water. It can be taken with or without food; however, a high-fat meal might slow its onset of action.

How Often Can I Take Sildenafil 50mg Tablets?

  • Use sildenafil only once per day.
  • Ensure there is at least a 24-hour gap between doses.

How Long Does It Take for Sildenafil 50mg Tablets to Work?

Sildenafil generally starts working within 30 to 60 minutes. The effects can last up to four hours, though this does not mean an erection will persist for the entire period.

What Are the Possible Side Effects of Sildenafil 50mg Tablets?

Common side effects may include:

  • Headache
  • Flushing
  • Indigestion
  • Nasal congestion
  • Dizziness
  • Visual disturbances

Rare but serious side effects include:

  • Chest pain (which may indicate a heart attack)
  • Sudden vision loss
  • A prolonged, painful erection (priapism), which requires immediate medical attention

Can I Take Sildenafil 50mg Tablets with Alcohol?

It is best to avoid excessive alcohol when taking sildenafil, as it can heighten side effects and may impair your ability to achieve an erection.

Are There Any Medications That Interact with Sildenafil 50mg Tablets?

Yes, sildenafil can interact with various medications, such as:

  • Nitrate medications (used for chest pain)
  • Certain blood pressure drugs
  • Some antibiotics and antifungal medications
  • HIV protease inhibitors

Always inform your healthcare provider about all the medications and supplements you are taking.

Can I Take Sildenafil 50mg if I Have a Heart Condition?

If you have a heart condition, consult your doctor before using sildenafil, as it may not be safe for individuals with certain heart problems.

What Should I Do If I Miss a Dose of Sildenafil 50mg?

Since sildenafil is taken as needed, missing a dose is unlikely. Do not take an extra dose to make up for a missed one.

Can Women Take Sildenafil 50mg Tablets?

Sildenafil is not approved for use in women. Other treatments are available for female sexual dysfunction.

What Should I Do If I Experience a Prolonged Erection?

If your erection lasts longer than four hours, seek immediate medical attention. This condition, known as priapism, can cause permanent damage if not treated promptly.

Can I Take Sildenafil 50mg with Other ED Medications?

Do not combine sildenafil with other erectile dysfunction treatments without consulting your doctor, as this may increase the risk of severe side effects.

How Should I Store Sildenafil 50mg Tablets?

Store the tablets at room temperature, away from moisture and heat. Keep them in their original packaging until you are ready to use them.

What Should I Do If I Overdose on Sildenafil 50mg Tablets?

If you suspect an overdose, seek emergency medical attention immediately. Overdose symptoms may include severe dizziness, fainting, or a prolonged erection.

What Are PDE5 Inhibitors?

PDE5 inhibitors are a class of medications that block the enzyme phosphodiesterase-5 (PDE-5), which regulates blood flow in the penis. By inhibiting PDE-5, these drugs help increase blood flow during sexual arousal, making it easier to achieve and maintain an erection. They are primarily used to treat erectile dysfunction but can also be effective for conditions such as pulmonary arterial hypertension. Common examples include sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra). Although generally well tolerated, these medications can cause side effects in some individuals and work best when combined with lifestyle changes and counseling.

Purchase Online

After completing our quick online consultation form, you can securely order Sildenafil 50mg tablets from courierpharmacy.co.uk. Enjoy fast, discreet delivery and an effective solution for managing erectile dysfunction.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.3172.pdf

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Checked By
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Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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