What is the Active Ingredient in Low Dose Naltrexone (LDN)?
Active Ingredient
Low Dose Naltrexone is formulated with naltrexone, available in doses not exceeding 4.5mg.
After completing our online consultation form, you can securely order this treatment from courierpharmacy.co.uk.
What is Low Dose Naltrexone (LDN) used for?
Overview
Low Dose Naltrexone (LDN) is used off-label to help manage various chronic and inflammatory conditions. It is specially compounded in lower doses compared to standard naltrexone, making it suitable for conditions where immune modulation and reduced inflammation are beneficial.
Common Uses
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Autoimmune Diseases
LDN is often used to manage conditions like multiple sclerosis (MS), rheumatoid arthritis, lupus, and Hashimoto's thyroiditis by helping to regulate the immune system and lower inflammation.
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Chronic Pain Disorders
It can be effective in reducing pain and improving quality of life in chronic pain conditions such as fibromyalgia and complex regional pain syndrome (CRPS).
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Inflammatory Bowel Diseases
LDN shows promise in easing symptoms of Crohn’s disease and ulcerative colitis by reducing inflammation in the gut.
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Cancer
Some patients use LDN as an additional therapy in cancer treatment to boost the immune system and potentially enhance treatment outcomes, although more research is needed.
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Neurological Disorders
It is also used in conditions like Parkinson’s disease and Alzheimer’s disease with the aim of slowing disease progression and easing symptoms, though evidence is still emerging.
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Irritable Bowel Syndrome (IBS)
LDN may help relieve symptoms of IBS, including abdominal pain and irregular bowel movements, by reducing intestinal inflammation.
Safety and Consultation
LDN is generally well-tolerated, but it is important to consult your healthcare provider to ensure it is appropriate for your condition.
After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.
How does Low Dose Naltrexone (LDN) work?
Overview
Low Dose Naltrexone (LDN) works differently than the standard 50mg dose used for addiction treatment. At lower doses—typically between 0.1mg and 6mg—naltrexone only partially blocks opioid receptors. This partial blockade encourages the body to increase its production of natural endorphins, which can help improve pain relief and modulate the immune system.
Mechanism of Action
- At high doses, naltrexone completely blocks opioid receptors, stopping opioid effects. At low doses, it only partially blocks these receptors.
- This partial inhibition triggers the body to boost its natural endorphin production, which enhances pain relief.
- Additionally, low-dose naltrexone appears to influence the immune system by modulating Toll-Like Receptors (TLRs) on immune cells.
Role of Naltrexone Isomers
- Naltrexone comes in two mirror-image forms, known as isomers.
- The "levo" isomer primarily acts on opioid receptors, promoting endorphin release.
- The "dextro" isomer targets Toll-Like Receptors, helping to reduce the release of pro-inflammatory cytokines.
- Together, these actions contribute to both pain relief and a balanced immune response.
Therapeutic Impact
By increasing endorphin levels and reducing excessive inflammation, LDN may help manage various conditions such as chronic pain, autoimmune diseases, and inflammatory disorders.
After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.
Who should not use Low Dose Naltrexone (LDN)?
Avoid Combining with Opiates
Do not use low-dose naltrexone 4.5mg transmucosal buccal film if you are taking any opiates. Although LDN partially blocks opioid receptors, high doses of opiates can still cause serious breathing and circulatory problems, possibly leading to opiate poisoning. Additionally, if you are dependent on opiates, using LDN can trigger severe withdrawal symptoms. Always inform every healthcare provider that you are using this medication. In an emergency where anesthesia is needed, non-opioid alternatives should be used; if opioid-based anesthetics are required, higher doses may be necessary, increasing your risk of side effects.
Liver and Kidney Considerations
Low-dose naltrexone 4.5mg transmucosal buccal film is metabolized by the liver and kidneys. Because individuals with opiate dependence often have liver issues, your doctor will conduct liver function tests before and during treatment.
Interactions with Other Medications
Tell your doctor or pharmacist if you are taking or have recently taken any other medications, including those obtained without a prescription. Some common medicines, such as cough syrups, diarrhea treatments, or pain relievers, may contain opiates and might be less effective while using LDN. In emergency situations, if opioid-containing drugs are necessary, you may require a higher dose for pain relief under close medical supervision due to the risk of increased respiratory depression and other adverse effects.
Food, Pregnancy, and Safety Precautions
Food and drink do not affect the performance of low-dose naltrexone 4.5mg transmucosal buccal film. If you are pregnant, breastfeeding, suspect you may be pregnant, or plan to conceive, consult your doctor or pharmacist before using this medication. LDN should only be used during pregnancy if the benefits outweigh the potential risks, and breastfeeding is not recommended. Also, since LDN may cause drowsiness or reduce alertness, do not drive or operate machinery if you experience these effects.
After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.
Does Low Dose Naltrexone (LDN) interact with other medicines?
Inform Your Doctor
Notify your doctor if you are taking, have recently taken, or plan to take any other medications, including over-the-counter products. Some common drugs contain opiates and may not work as intended while you are using low-dose naltrexone.
Medications to Watch
- If you need cough syrups, diarrhea medications, or pain relievers, inform your doctor because these might contain opiates.
- In emergency situations requiring opioid drugs, higher doses may be necessary for adequate pain relief. This requires close medical supervision due to the increased risk of respiratory depression and other severe side effects.
After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.
