LDN consultation: What to expect
If you’re considering Low Dose Naltrexone (LDN) as part of your treatment plan, our LDN consultation is designed to give you safe, personalised guidance every step of the way. The process starts with a secure online questionnaire, where you’ll share your medical history, current symptoms, and any previous treatments. This helps our experienced clinical team understand your unique needs and determine if LDN may be suitable for you.
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LDN consultation
Start your journey with LDN by completing our straightforward online consultation. This secure process allows you to provide important details about your medical history, current symptoms, and any previous treatments from the comfort of your own home. Our clinical team will carefully review your information to determine if Low Dose Naltrexone (LDN) is a suitable option for you.
Once your online consultation is complete and you’ve been approved, you’ll have the flexibility to select the LDN formulation that best fits your needs—whether that’s capsules, liquid, or another option. We understand that everyone’s preferences and requirements are different, so we offer a range of formulations to make your treatment as convenient and effective as possible.
After you’ve started your LDN treatment, we don’t just leave you on your own. Regular follow-up consultations will be arranged with our prescribers to see how you’re getting on, address any concerns, and make adjustments to your treatment plan if needed. These follow-ups are an important part of your care, ensuring you’re supported throughout your LDN journey and giving you the chance to ask questions or discuss any changes in your symptoms.
If at any point you’re unsure about which LDN formulation is right for you, or if you’d simply like more guidance, you can request a phone or video consultation with our experienced team. We’re here to help you understand your options, answer any questions, and provide tailored recommendations based on your individual needs. Our goal is to make the process as smooth, safe, and supportive as possible, so you can feel confident in your treatment decisions. If you need extra help or would like to book a consultation, please don’t hesitate to contact us—our friendly team is always here for you.
An LDN online consultation is a secure, convenient way to have your medical history and symptoms reviewed by our clinical team to see if Low Dose Naltrexone is suitable for you.
Simply complete our online assessment form, providing details about your health, symptoms, and any current medications.
Yes, once your consultation is approved, you can select the LDN formulation that best suits your needs, such as capsules or liquid.
Absolutely! Our prescribers will follow up to monitor your progress, address any concerns, and adjust your treatment plan if needed.
If you need additional support or want to book a further consultation, just contact our team—we’re here to help.
Yes, all your details are handled securely and confidentially in line with strict data protection standards.
Our compounded medicines are shipped via Royal Mail with a tracking service for your peace of mind. Parcels must be signed for upon delivery and cannot be left unattended or posted through a letterbox, ensuring the integrity of the product is maintained throughout transit.
Fibromyalgia
Fibromyalgia is a long-term condition that causes widespread pain, tenderness, and fatigue throughout the body. People with fibromyalgia often experience sleep problems, memory issues (sometimes called “fibro fog”), and heightened sensitivity to pain. The exact cause isn’t fully understood, but it’s thought to involve changes in how the brain and nervous system process pain signals.
Living with fibromyalgia can be challenging, as symptoms can fluctuate and sometimes interfere with daily activities. Many people find that stress, weather changes, or physical activity can make symptoms worse. Management often requires a combination of treatments and self-care strategies tailored to each individual’s needs.
Support from healthcare professionals, family, and friends is important. Regular exercise, good sleep habits, and stress management techniques can help improve quality of life for those living with fibromyalgia.
Complete the low dose naltrexone consultation to see if LDN is suitable for you.
Widespread pain, fatigue, sleep problems, and “fibro fog” are common.
It can affect anyone but is more common in women and usually develops between ages 30 and 60.
Doctors diagnose it based on symptoms and by ruling out other conditions.
There is no cure, but symptoms can be managed with treatment and lifestyle changes.
The exact cause isn’t known, but it’s believed to involve how the brain and nerves process pain. Stress, infections, injuries, or genetics may play a role in triggering it.
No, it’s not arthritis. Although both involve pain and fatigue, fibromyalgia doesn’t cause inflammation or damage to joints or tissues like arthritis does.
A recent review of five clinical trials found that low-dose naltrexone (LDN) can help reduce pain in people with fibromyalgia, a condition that causes long-lasting body pain and tiredness. Compared to a placebo (dummy pill), LDN showed moderate pain relief, although it didn’t improve pain sensitivity (how much pressure causes pain). The treatment didn’t cause serious side effects, but vivid dreams were more common in those taking LDN. Overall, LDN appears safe and helpful for fibromyalgia, but more research is needed to confirm these findings [1].
References:
Chronic Fatigue Syndrome (CFS/ME)
Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a condition that causes extreme tiredness that doesn’t improve with rest. People with CFS/ME may also have problems with memory and concentration, muscle and joint pain, headaches, and sleep disturbances.
The exact cause of CFS/ME isn’t known, but it may be triggered by infections, immune system changes, or stress. Symptoms can vary from person to person and may come and go, making it hard to predict how you’ll feel day to day.
Managing CFS/ME often involves pacing yourself, balancing activity with rest, and working with healthcare professionals to address symptoms. Support, understanding, and self-care play a big role in living well with this condition.
Complete the low dose naltrexone consultation to see if LDN is suitable for you.
CFS, or ME/CFS, is a long-term condition that causes extreme tiredness that doesn’t get better with rest. It can also cause problems with sleep, memory, and pain.
The exact cause isn’t fully understood. It may be triggered by infections, immune system problems, hormone imbalances, or long-term stress. In many cases, it starts after a viral illness.
- Constant, deep tiredness
- Feeling worse after physical or mental effort (called “post-exertional malaise”)
- Sleep that doesn’t feel refreshing
- Brain fog (poor concentration or memory)
- Muscle or joint pain
There’s no single test. Doctors diagnose CFS by ruling out other conditions and checking if symptoms have lasted 6 months or more and can’t be explained by anything else.
There’s no cure at the moment, but symptoms can be managed. Treatments focus on improving quality of life through rest, pacing activities, sleep support, gentle exercise, and mental health care.
No — CFS is more than everyday tiredness. It’s a medical condition where even small tasks can leave someone feeling completely drained for days. The fatigue is often disabling and not relieved by sleep or rest.
A review of medical records from 218 people with ME/CFS (chronic fatigue syndrome) found that low-dose naltrexone (LDN), taken at 3.0–4.5 mg per day, helped about 74% of patients feel better. Many reported improved energy, alertness, and mental clarity, and some had less pain and fever. Mild side effects like nausea or trouble sleeping were common at first, but no serious or long-term side effects were seen. These findings suggest LDN could be a safe and promising option for managing ME/CFS symptoms, though more research is needed to confirm this [1].
References:
Long COVID
Long COVID refers to symptoms that continue for weeks or months after the initial COVID-19 infection has cleared. Common symptoms include fatigue, breathlessness, brain fog, chest pain, joint pain, and changes in taste or smell.
Long COVID can affect anyone, even those who had mild or no symptoms with the original infection. The exact cause is still being researched, but it’s thought to involve lingering inflammation, immune responses, or changes to the nervous system.
Managing long COVID usually involves working with healthcare professionals to create a personalised recovery plan. This may include physical therapy, breathing exercises, and support for mental health and wellbeing.
Complete the low dose naltrexone consultation to see if LDN is suitable for you.
Long COVID is when symptoms continue for weeks or months after the initial COVID-19 infection has gone. Even people who had a mild case of COVID can get Long COVID.
- Symptoms vary, but often include:
- Ongoing fatigue
- Brain fog (poor memory or focus)
- Shortness of breath
- Chest pain or palpitations
- Muscle or joint aches
- Anxiety, depression, or sleep problems
Symptoms may come and go or get worse after activity.
It depends. Some people recover within a few months, while others may take longer. A small number may still have symptoms over a year later.
Anyone can get Long COVID, including young, healthy people. It’s more likely in those who had more severe COVID, but even mild cases can lead to long-term symptoms.
There’s no single test. Doctors usually make a diagnosis based on your history of COVID, how long symptoms have lasted, and by ruling out other causes.
No. Long COVID is not contagious — it’s a result of the body’s response to the original infection. You can’t catch Long COVID from someone who has it.
Early research suggests that low-dose naltrexone (LDN) may help ease Long COVID symptoms, especially fatigue, post-exertional malaise (crashing after activity), poor sleep, and pain. In one small study, people reported better mood, less chest tightness, and less joint pain after taking LDN for two months. Another study found that LDN improved tiredness and sleep issues in many patients, no matter how long they’d had symptoms — even if it had been over a year [1].
References:
- Medical Mojo. (n.d.). Long COVID and LDN. Available at: https://medicalmojo.co.uk/long-covid-and-ldn/ (Accessed: 19 June 2025).
Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease, or IBD, is a term used for a group of conditions that cause ongoing inflammation in the digestive tract. The two main types of IBD are Crohn’s disease and ulcerative colitis. Both conditions can cause similar symptoms, but they affect different parts of the gut and can vary in how they progress.
People with IBD often experience symptoms such as:
- Ongoing stomach pain or cramps
- Diarrhoea (sometimes with blood or mucus)
- Tiredness and low energy
- Weight loss or poor appetite
- Urgent need to go to the toilet
Symptoms can come and go, with periods of flare-ups (when symptoms are worse) and remission (when symptoms improve or disappear).
The exact cause of IBD is not fully understood, but it’s believed to be a mix of genetics, immune system problems, and environmental factors like diet and stress. IBD is a lifelong condition, but with the right treatment and support, many people can manage their symptoms and live full lives.
Treatment for IBD usually includes medication to reduce inflammation, changes in diet, and sometimes surgery. Regular check-ups with your healthcare team are important to monitor your condition and make sure your treatment is working.
Complete the low dose naltrexone consultation to see if LDN is suitable for you.
Crohn’s disease can affect any part of the digestive tract, from the mouth to the anus, and can involve all layers of the bowel wall. Ulcerative colitis only affects the colon (large intestine) and rectum, and usually just the inner lining.
- Symptoms vary, but often include:
- Ongoing fatigue
- Brain fog (poor memory or focus)
- Shortness of breath
- Chest pain or palpitations
- Muscle or joint aches
- Anxiety, depression, or sleep problems
Symptoms may come and go or get worse after activity.
Common symptoms include stomach pain, diarrhoea (sometimes with blood), tiredness, weight loss, and feeling unwell. Some people also have joint pain, eye problems, or skin rashes.
Doctors use a combination of blood tests, stool tests, endoscopy (a camera to look inside your gut), and scans to diagnose IBD and rule out other conditions.
There is currently no cure for IBD, but treatments can help control symptoms and reduce flare-ups. Many people have long periods with few or no symptoms.
Yes, certain foods can trigger symptoms for some people. Working with a dietitian can help you find a diet that works for you and keeps you healthy.
A recent study looked at people with inflammatory bowel disease (IBD) who hadn’t responded well to standard treatments and were given Low Dose Naltrexone (LDN). The results were encouraging: about three out of four patients (74.5%) felt better after starting LDN, and about one in four (25.5%) experienced long-lasting remission—meaning their symptoms improved and stayed away for a significant time. Most people who went into remission also showed real improvements when their gut was examined with a camera. While these results are slightly lower than what some earlier, smaller studies found, it’s important to note that the people in this study had more severe disease to begin with [1].
Importantly, no serious side effects were reported, and there were no problems with liver function, which sometimes happens with Naltrexone. This suggests that LDN is a safe and promising option for people with tough-to-treat IBD.
How does LDN work?
The exact way LDN helps IBD isn’t fully understood, but scientists have some ideas. Naltrexone seems to calm down the immune system and reduce inflammation in the gut. It may also help the gut lining heal and reduce stress on gut cells, making it easier for the body to repair itself. Some of these effects might be due to how Naltrexone interacts with certain pain and immune receptors, and possibly by blocking some of the pathways that cause inflammation.
Another interesting finding is that LDN may help reduce “ER stress” in gut cells—a type of cellular stress linked to IBD. By helping these cells function better, LDN might support gut healing and reduce symptoms [1].
Overall, the study suggests that LDN is both safe and effective for people with IBD who haven’t had success with other treatments. The side effects are mild, and the benefits could be significant, especially for those with severe disease. More research is needed, especially to see if LDN could help people earlier in their IBD journey, not just those with the most difficult cases.
References:
Mast Cell Activation Syndrome (MCAS)
Mast Cell Activation Syndrome (MCAS) is a condition where certain cells in your immune system—called mast cells—release too many chemicals into your body at the wrong times. Mast cells are a normal part of your immune system and help protect you from infections.
They release substances like histamine when you have an allergic reaction. But in MCAS, these cells can become overactive, releasing their chemicals even when there’s no real threat. This can cause a wide range of symptoms that often seem unrelated, making MCAS tricky to diagnose.
- People with MCAS might experience symptoms such as:
- Skin reactions (hives, itching, flushing)
- Stomach problems (nausea, diarrhoea, cramping)
- Swelling (face, lips, throat, or other areas)
- Headaches or brain fog
- Breathing difficulties (wheezing, shortness of breath)
- Rapid heartbeat or low blood pressure
- Symptoms can come and go, and different things—like certain foods, stress, temperature changes, or even exercise—can trigger them. Because the symptoms can mimic other conditions, MCAS is often missed or misdiagnosed at first.
Managing MCAS usually involves identifying and avoiding your personal triggers, taking medications like antihistamines to block the chemicals mast cells release, and sometimes using other treatments to calm the immune system. Working with a knowledgeable doctor is key to getting the right diagnosis and support.
Complete the low dose naltrexone consultation to see if LDN is suitable for you.
MCAS happens when mast cells in the body become overly sensitive and release chemicals too easily. The exact cause isn’t always known, but genetics, chronic infections, or other immune system problems may play a role.
Symptoms vary but often include skin rashes, itching, flushing, stomach pain, diarrhoea, headaches, swelling, low blood pressure and sometimes breathing issues.
Diagnosis can be challenging because symptoms overlap with other conditions. Doctors may use blood or urine tests to check for chemicals released by mast cells, along with a careful review of symptoms and medical history.
Triggers are different for everyone but may include certain foods, medications, stress, temperature changes, exercise, or even strong smells.
No, but they are related. Allergies involve the immune system reacting to a specific substance, while MCAS is about mast cells being overactive in general, even without a clear allergen.
Treatment often includes antihistamines, medications to block other mast cell chemicals, and lifestyle changes to avoid triggers. In some cases, other immune-modulating medications may be used.
Mast cells (MCs) are special cells in your immune system that act like sentries—always on the lookout for things like allergens, infections, or injuries. When they detect a problem, they release chemicals such as histamine and TNF (tumor necrosis factor) to help your body react and protect itself. But sometimes, mast cells can become overactive and release these chemicals too often or at the wrong times, which can lead to ongoing inflammation and a range of health problems. This is what happens in conditions like Mast Cell Activation Syndrome (MCAS).
One of the key chemicals released by mast cells is TNF. TNF plays a big role in inflammation and is linked to many symptoms seen in chronic conditions, including pain, fatigue, and even sleep issues.
Where does Low Dose Naltrexone (LDN) fit in?
Naltrexone is a medication that, in high doses (about 50mg), is used to treat opioid and alcohol addiction. But at much lower doses (usually around 4.5mg), it works differently. In small doses, LDN can actually help calm down the immune system and reduce inflammation—including the kind caused by overactive mast cells.
LDN has been used to help people with MCAS, as well as other inflammatory and immune-related conditions like multiple sclerosis, Crohn’s disease, and even some cases of long COVID. Research suggests that LDN works by:
- Calming the immune system: LDN helps reduce the release of inflammatory chemicals like TNF from both mast cells and other immune cells in the body.
- Balancing inflammation: At low doses, LDN seems to “reset” the immune system, helping it respond more appropriately instead of overreacting.
- Improving symptoms: Some small studies have shown that people taking LDN experience less pain, less fatigue, and fewer other symptoms connected to chronic inflammation.
LDN appears to do this by affecting certain receptors (like TLR4) and by increasing the body’s own natural painkillers and anti-inflammatory signals. Importantly, LDN’s effects are dose-dependent—meaning that higher doses can actually worsen inflammation, while low doses help reduce it.
Why does this matter for conditions like MCAS and chronic inflammation?
Because mast cells and their chemical messengers (like TNF) are involved in so many symptoms—from allergies and digestive issues to pain and fatigue—finding a treatment that can “turn down the volume” on their activity can make a big difference for people who struggle with these problems. LDN offers a promising option for calming the immune system and reducing the impact of mast cell-related inflammation, with fewer side effects compared to some other medications [1].
In summary:
- Mast cells help defend your body, but when they’re too active, they can cause inflammation and various symptoms.
- TNF is one of the main chemicals they release, and it’s linked to many symptoms in chronic conditions.
- Low Dose Naltrexone (LDN) can help reduce the activity of mast cells and lower inflammation, offering relief for people with MCAS and similar issues.
If you think you might have MCAS or are interested in LDN as a treatment, it’s important to speak with a healthcare professional who understands these conditions and can guide you on the best options for your situation.
