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Flucloxacillin 500mg capsules (28)
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Flucloxacillin 500mg capsules are an oral antibiotic used to treat bacterial infections caused by penicillin-resistant staphylococci and other bacteria. It is commonly prescribed for skin infections and nail bed infections.
Product description of flucloxacillin 500mg capsules
Flucloxacillin 500mg capsules are a type of penicillin antibiotic designed to combat infections caused by bacteria, particularly those resistant to some penicillin types [2]. It is highly effective against staphylococcal infections, which commonly affect the skin and soft tissues [1].
This medication is available in capsule form, allowing for easy oral administration. It is often prescribed for treating infections such as chest infections, throat infections, ear infections, skin infections, bone infections, meningitis, digestive system infections, blood infections, and urinary tract infections [1], [2].
Flucloxacillin capsules can also be used prophylactically to prevent infections during major surgeries, especially heart or orthopaedic operations [1], [2].
Broad-spectrum antibiotic effective against penicillinase-producing bacteria [1].
A comprehensive guide to flucloxacillin 500mg capsules: uses, dosage, side effects, and everything you need to know
Flucloxacillin 500mg capsules are an effective antibiotic used to treat a range of bacterial infections, especially those caused by penicillinase-producing bacteria [1], [2].
This oral medication is commonly prescribed for skin infections, respiratory infections, bone and joint infections, and to prevent infections during surgery [1], [2].
Understanding dosage, side effects, and precautions is essential for safe and effective use [1], [3].
Flucloxacillin belongs to the penicillin family and works by killing bacteria that cause infections [2].
Always take flucloxacillin as prescribed and consult your healthcare provider if you have any concerns or experience side effects [1].
Overview of flucloxacillin 500mg capsules
Effective against penicillinase-producing bacteria causing various infections [1], [3].
Available as oral capsules for easy administration [2].
Dosage varies by infection type and patient characteristics [1], [2].
Requires medical supervision to avoid side effects and interactions [1], [3].
Used both for treatment and prevention of infections [1], [2].
Flucloxacillin 500mg capsules are a reliable choice for treating a broad range of bacterial infections. Their effectiveness against resistant strains of bacteria makes them particularly valuable in clinical settings [1], [2].
The oral capsule form offers convenience for patients, supporting adherence to treatment plans [2].
Proper dosing and timing are crucial to maximise the benefits of flucloxacillin while minimising potential side effects [1].
Medical supervision ensures that the treatment is safe, especially for patients with other health conditions or who are taking multiple medications [3].
Flucloxacillin’s role in preventing infections during surgery highlights its importance in both treatment and prophylaxis [1], [2].
Active ingredient in flucloxacillin 500mg capsules
The active ingredient in these capsules is flucloxacillin sodium, a beta-lactam antibiotic belonging to the penicillin group. It works by inhibiting the synthesis of bacterial cell walls, leading to the destruction of susceptible bacteria [2].
Flucloxacillin is particularly effective against penicillinase-producing staphylococci, which can cause stubborn infections resistant to other penicillins [1].
What are flucloxacillin 500mg capsules used for?
Flucloxacillin 500mg capsules are prescribed to treat infections caused by susceptible bacteria. These include skin and soft tissue infections such as boils and abscesses, respiratory tract infections like pneumonia, bone and joint infections, and infections of the ear, throat, and urinary tract [1], [2].
They are also used to prevent infections during surgical procedures, particularly heart and orthopaedic surgeries, where the risk of bacterial contamination is high [1], [2].
Due to its targeted action against penicillinase-producing bacteria, flucloxacillin is a preferred treatment option for infections where resistant staphylococci are suspected [1], [3].
How do flucloxacillin 500mg capsules work?
Flucloxacillin works by interfering with the bacteria’s ability to build cell walls, a vital component for their survival. Without a proper cell wall, bacteria become vulnerable and eventually die [2].
Its beta-lactam structure allows it to bind to specific enzymes called penicillin-binding proteins, which are essential for cell wall synthesis. By disrupting these proteins, flucloxacillin prevents bacteria from maintaining their structural integrity [1], [2].
This mechanism is particularly effective against penicillinase-producing staphylococci, which produce enzymes that inactivate other penicillins but are susceptible to flucloxacillin [1].
The result is a rapid reduction in bacterial numbers, leading to the resolution of infection symptoms [2].
Because flucloxacillin targets bacterial cell walls, it is effective only against actively growing bacteria and has no effect on viruses or fungi [1].
How to take flucloxacillin 500mg capsules
Take flucloxacillin capsules exactly as prescribed by your healthcare provider. It is important to swallow the capsules whole with a full glass of water to reduce the risk of irritation in your oesophagus [2].
The usual dose is one capsule four times daily for 7 days.
Take the capsules on an empty stomach, at least one hour before or two hours after meals, to ensure optimal absorption [1], [2].
Do not skip doses or stop treatment early, even if you feel better, as this can lead to the infection returning and antibiotic resistance developing [1].
Warnings and precautions for flucloxacillin 500mg capsules
Do not take flucloxacillin if you are allergic to penicillins or any other ingredients in the capsules. Inform your doctor if you have a history of liver or kidney problems, as dosage adjustments may be necessary [1], [2].
Flucloxacillin may cause side effects such as stomach upset or allergic reactions; seek medical advice if you experience symptoms like rash, itching, swelling, or difficulty breathing [1].
Do not take Flucloxacillin capsules if:
You’ve ever had an allergic reaction to flucloxacillin or any other penicillin antibiotics (like amoxicillin, for example) [1], [2].
You’re allergic to any of the ingredients in this medicine (check the leaflet or ask your pharmacist) [1], [2].
You’ve had liver problems (like yellow skin or eyes, called jaundice) after taking flucloxacillin in the past [1], [2].
You’ve reacted badly to other “?-lactam” antibiotics (these include penicillins and cephalosporins) [1], [2].
Warnings and precautions – talk to your doctor or pharmacist before taking Flucloxacillin capsules if:
You have kidney problems (you might need a lower dose, and rare side effects like fits are more likely with high doses) [1], [2].
You have liver problems (this medicine could make them worse) [1], [2].
You are taking or planning to take paracetamol [1], [2].
Important note:
Taking flucloxacillin together with paracetamol can sometimes cause a rare but serious problem called “high anion gap metabolic acidosis.” This is when the body’s fluids become too acidic, especially in people with severe kidney problems, infections like sepsis, or poor nutrition—particularly if you’re using the maximum daily dose of paracetamol. If you’re at risk, your doctor will keep a close eye on you [1], [2].
Pregnant or breastfeeding women should consult their doctor before using flucloxacillin [1].
Regular monitoring of liver and kidney function may be advised during prolonged treatment [3].
Side effects of flucloxacillin 500mg capsules
Like all medicines, flucloxacillin can cause side effects, but not everyone gets them [2]. Stop taking the medicine and contact your doctor immediately if you notice:
Severe allergic reactions like:
Itchy rash or itching
Sore mouth or eyes
Swelling of the face, lips, throat, or tongue
Trouble breathing
Severe bloody diarrhoea (a serious gut infection called pseudomembranous colitis)
Signs of liver problems such as:
Yellowing of the skin or eyes (jaundice)
Liver inflammation (hepatitis) — these can sometimes show up up to 2 months after finishing treatment
Serious skin reactions like:
Severe rash with flushing, fever, blisters, or ulcers (Stevens-Johnson syndrome)
Rash with red, peeling, swollen skin that looks like a burn (toxic epidermal necrolysis)
Red, scaly rash with bumps and blisters under the skin (exanthematous pustulosis)
Changes in blood cell counts causing unexplained bleeding, bruising, or skin colour changes
Tell your doctor if you notice any of these or other side effects:
Common (up to 1 in 10 people):
Mild stomach upset or diarrhoea
Very rare (up to 1 in 10,000 people):
Kidney inflammation
Anaemia (low red blood cells)
Circular red skin rash (erythema multiforme)
Joint or muscle pain, fever (can start after 2 days or more of treatment)
Blood and fluid imbalance (high anion gap metabolic acidosis), especially if taken with paracetamol and if you have risk factors like kidney problems or malnutrition
Unknown frequency:
Serious skin reactions (exanthematous pustulosis) — get medical help immediately if this occurs
Low potassium levels in blood causing muscle weakness, twitching, or irregular heartbeat
Pain or irritation in the oesophagus (food pipe), difficulty swallowing, heartburn, throat irritation, or chest pain
Reporting side effects:
If you experience any side effects, talk to your doctor, pharmacist, or nurse. You can also report side effects directly through the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or via the MHRA Yellow Card app on Google Play or Apple App Store. Reporting helps improve medicine safety for everyone.
Drug interactions with flucloxacillin 500mg capsules
Flucloxacillin may interact with various medications including [1], [3]:Probenecid or sulfinpyrazone (for treating gout)
Methotrexate (a medicine sometimes used for cancer or some immune conditions)
The oral typhoid vaccine (antibiotics like flucloxacillin can stop this working properly)
Sugammadex (used during some types of anaesthesia in hospital)
Piperacillin (another antibiotic, usually given as an injection)
Warfarin (a blood thinner to prevent clots)
Paracetamol (for pain or fever)
Any other antibiotics (for infections)
Voriconazole (used to treat fungal infections)
Always inform your healthcare provider about all medicines and supplements you are taking to avoid potential interactions [1].
Your doctor will advise you on any necessary dose adjustments or precautions.
FAQ about flucloxacillin 500mg capsules
What infections can flucloxacillin 500mg capsules treat?
They treat infections caused by penicillinase-producing bacteria including skin infections, respiratory tract infections, bone infections, and urinary tract infections.
How should I take flucloxacillin capsules?
Take the capsules on an empty stomach with a full glass of water, at least one hour before or two hours after food.
Can I stop taking flucloxacillin when I feel better?
No, complete the full course to prevent resistance and relapse.
Are there any common side effects?
Mild stomach upset and diarrhoea are common but usually temporary.
Can flucloxacillin cause allergic reactions?
Yes, watch for rash, itching, swelling, or breathing difficulties and seek urgent care if these occur.
Is flucloxacillin safe during pregnancy?
Consult your doctor before use if pregnant or breastfeeding.
Can I drink alcohol while taking flucloxacillin?
Alcohol is not known to interact significantly but should be consumed in moderation.
How long does it take to work?
Improvement is usually seen within a few days, but complete the course.
What if I miss a dose?
Take it as soon as you remember unless it's near the next dose; do not double dose.
Can flucloxacillin be used for viral infections?
No, antibiotics do not treat viruses.
Can children take flucloxacillin capsules?
Yes, doses are adjusted for children based on age and weight.
Can flucloxacillin cause diarrhoea?
Yes, mild diarrhoea is common; severe diarrhoea should be reported.
What should I avoid while taking flucloxacillin?
Avoid missing doses and inform your doctor about other medications.
Is it safe to take flucloxacillin with other antibiotics?
Inform your doctor as some antibiotics may interact.
Can flucloxacillin cause liver problems?
Rarely, it may affect liver function; monitoring may be needed.
How should I store flucloxacillin capsules?
Store below 25°C in the original packaging and keep out of reach of children.
Can flucloxacillin cause joint or muscle pain?
Rare side effect; report to your doctor if it occurs.
Disclaimer: This article is for informational purposes only and does not replace professional medical advice.
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