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Hiprex 1g tablets (60)

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Hiprex 1g tablets contain methenamine hippurate, a non-antibiotic treatment used to prevent and manage recurrent urinary tract infections by releasing formaldehyde in the bladder to kill bacteria and reduce infection risk.

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Recurrent cystitis

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Tablet

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Hiprex 1g tablets
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Description

Product description: Hiprex (Methenamine Hippurate) 1g Tablet for UTI

Hiprex 1g tablets contain methenamine hippurate, which breaks down in the acidic environment of the bladder to release formaldehyde. This formaldehyde acts as a powerful antibacterial agent, killing bacteria and preventing infection recurrence [3].

Key points about Hiprex include:

  • Contains 1g of methenamine hippurate per tablet.
  • Used primarily for prevention and treatment of recurrent lower urinary tract infections.
  • Non-antibiotic mechanism reduces risk of antibiotic resistance.
  • Suitable for long-term use with medical supervision.
  • Available on prescription only.

Hiprex is an effective option for patients who have frequent UTIs and want to reduce antibiotic use, or for those who cannot tolerate antibiotics.

It’s important to take Hiprex exactly as prescribed and to maintain communication with your healthcare provider during treatment.

Additional information

Quantity

1 x 60, 2 x 60, 3 x 60, 4 x 60, 6 x 60

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


Checked By
Safdar Ali
BSc Pharmacy

Pharmacist


Overview: Hiprex (Methenamine Hippurate) 1g Tablet for UTI

  • Hiprex is a trusted treatment for urinary tract infections (UTIs), especially recurrent infections.
  • It works by releasing formaldehyde in the bladder, which kills bacteria and helps prevent infections returning.
  • Hiprex is a non-antibiotic alternative that supports antibiotic stewardship by reducing the need for antibiotics.
  • The tablet is generally well tolerated and suitable for long-term use under medical supervision.
  • It’s widely recommended in NHS and NICE guidelines for managing recurrent UTIs [1] [2] [4].

Hiprex (methenamine hippurate) 1g tablets offer a unique approach to managing urinary tract infections, particularly for those who experience frequent recurrences. Unlike antibiotics, Hiprex works by creating an unfavourable environment for bacteria in the bladder, reducing infection risk without contributing to antibiotic resistance.

This makes Hiprex a valuable option for patients seeking long-term prevention of UTIs, especially when antibiotics are not suitable or have been used extensively in the past.

Hiprex versus antibiotics courierpharmacy.co.uk

Key points about Hiprex include:

  • Contains 1g of methenamine hippurate per tablet.
  • Used primarily for prevention and treatment of recurrent lower urinary tract infections.
  • Non-antibiotic mechanism reduces risk of antibiotic resistance.
  • Suitable for long-term use with medical supervision.
  • Available on prescription only.

Hiprex is an effective option for patients who have frequent UTIs and want to reduce antibiotic use, or for those who cannot tolerate antibiotics.

It’s important to take Hiprex exactly as prescribed and to maintain communication with your healthcare provider during treatment.

As a non-antibiotic, Hiprex is generally well tolerated, with fewer side effects than many traditional treatments, making it suitable for ongoing use under professional medical guidance.

If you’re using methenamine hippurate as a preventative treatment for urinary tract infections, it’s important to avoid over-the-counter sachets that make your urine more alkaline—such as those containing potassium citrate or sodium citrate (often used to ease UTI symptoms). These products can reduce the effectiveness of methenamine hippurate.
If you develop new or acute UTI symptoms while on methenamine hippurate, seek medical advice promptly rather than self-treating.
Your treatment with methenamine hippurate should be reviewed by your healthcare provider within 6 months of starting, and then at least every 12 months after that—or sooner if you and your clinician agree it’s needed.

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Active ingredient: Hiprex (Methenamine Hippurate) 1g Tablet for UTI

The active ingredient in Hiprex is methenamine hippurate. This compound is unique because it only becomes active in acidic urine, where it breaks down to release formaldehyde, a powerful agent that kills bacteria and prevents them from multiplying [2].

Because it’s not an antibiotic, methenamine hippurate doesn’t contribute to antibiotic resistance, making it a valuable choice for long-term UTI prevention [1].

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What is Hiprex (Methenamine Hippurate) 1g Tablet for UTI for?

Hiprex (Methenamine Hippurate) 1g Tablet is used to prevent and manage recurrent urinary tract infections (UTIs), especially in people who experience frequent episodes of cystitis. It’s often recommended when antibiotics are not suitable, or when someone wants to avoid repeated antibiotic use [4].

UTIs are particularly common in women, but men and children can also be affected. Hiprex is suitable for adults and, in some cases, older children, but always check with a healthcare professional before starting treatment [1].

It’s not used to treat an active, severe infection on its own and antibiotics may be needed for acute symptoms,  but it’s excellent for prevention and long-term management [2].

In summary, Hiprex acts like a security guard for your bladder, keeping bacteria at bay and helping you stay infection-free.

The Hiprex Shield courierpharmacy.co.uk

How does Hiprex (Methenamine Hippurate) 1g Tablet for UTI work?

Hiprex works by turning into formaldehyde in the bladder’s naturally acidic environment. Formaldehyde is a strong antiseptic that kills bacteria responsible for urinary tract infections, stopping them from causing trouble [3].

This process only happens in acidic urine, so Hiprex is most effective when your urine isn’t too alkaline. Sometimes your doctor may recommend avoiding certain foods or medicines that make urine less acidic [2].

Because it’s not an antibiotic, Hiprex doesn’t disrupt your gut bacteria or increase the risk of antibiotic resistance. This makes it a great option for people needing long-term protection from UTIs [4].

Hiprex can also be used alongside many antibiotics, though there are exceptions (such as co-trimoxazole) where it should not be combined [3].

In summary, Hiprex acts like a security guard for your bladder, keeping bacteria at bay and helping you stay infection-free.

How Hiprex works courierpharmacy.co.uk

How to use Hiprex (Methenamine Hippurate) 1g Tablet for UTI

Take one Hiprex tablet (1g) twice daily, morning and evening, with a full glass of water. Swallow the tablet whole and don’t crush or chew it [2].

Try to take Hiprex at the same times each day to keep the medicine working consistently. If you miss a dose, just take the next one as scheduled and don’t double up [3].

For best results, follow your doctor’s instructions carefully and complete the recommended course, even if you’re feeling fine. Always check with your healthcare provider before starting or stopping Hiprex, or if you have any concerns about side effects or interactions [4].

Hiprex dosage courierpharmacy.co.uk

Warnings and precautions

Before taking Hiprex, tell your doctor if you have any allergies or medical conditions, especially kidney or liver problems. Hiprex should be used with caution in these situations and under close medical supervision [3].

Hiprex is not recommended during pregnancy or breastfeeding unless your doctor advises it. Always discuss your full medical history with your healthcare provider before starting treatment [2].

If you experience any unusual symptoms such as rash, difficulty breathing, or swelling, seek medical advice immediately.

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Side effects

Hiprex is generally well tolerated, with few reported side effects. Some people may experience mild stomach upset, nausea, or skin rash [3].

If you notice any severe or persistent side effects, contact your healthcare provider promptly.

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Drug interactions

Hiprex can interact with some medications, including co-trimoxazole, which should not be taken together due to increased risk of bladder irritation and crystal formation [3].

Methenamine hippurate may increase the risk of crystalluria (the formation of crystals in the urine) when taken alongside certain medications. Specifically, it is advised to avoid combining methenamine with:
  • Sulfadiazine
  • Sulfamethoxazole
  • Sulfasalazine
These combinations can potentially cause serious side effects, so always inform your healthcare provider about all the medicines you’re taking to avoid harmful interactions.

Always inform your healthcare provider about all medicines and supplements you are taking to avoid potential interactions.

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FAQs

What is Hiprex (Methenamine Hippurate) 1g Tablet used for?

Hiprex is used to prevent and manage recurrent urinary tract infections by killing bacteria in the bladder [1].

Is Hiprex an antibiotic?

No, Hiprex is not an antibiotic. It works by releasing formaldehyde in the bladder to kill bacteria without contributing to antibiotic resistance [2].

Can I take Hiprex with antibiotics?

Yes, except for co-trimoxazole, Hiprex can be taken alongside many antibiotics and may even work better together [3].

How long does it take for Hiprex to work?

Hiprex is used for prevention and may take several weeks of regular use to reduce UTI frequency [4].

Can I take Hiprex during pregnancy?

Only if your doctor advises it. Always discuss your pregnancy status with your healthcare provider before starting Hiprex [2].

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Disclaimer: This article is for informational purposes only and does not replace professional medical advice.

References

  1. NHS (2024) Cystitis. [Online] NHS. Available at: https://www.nhs.uk/conditions/cystitis/ (Accessed: 07 September 2025).
  2. BNF (2025) Methenamine hippurate. [Online] NICE British National Formulary. Available at: https://bnf.nice.org.uk/drugs/methenamine-hippurate/ (Accessed: 25 September 2025).
  3. EMC (2025) Methenamine hippurate 2D Summary of Product Characteristics. [Online] electronic Medicines Compendium. Available at: https://www.medicines.org.uk/emc/product/1530/smpc (Accessed: 25 September 2025).
  4. CKS (2025) Recurrent urinary tract infection (no haematuria, not pregnant or catheterized) 2D management. [Online] NICE Clinical Knowledge Summaries. Available at: https://cks.nice.org.uk/topics/urinary-tract-infection-lower-women/management/recurrent-uti-no-haematuria-not-pregnant-or-catheterized/ (Accessed: 25 September 2025).

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Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.1530.pdf

Checked By
Safdar Ali
BSc Pharmacy

Pharmacist


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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