What are Ketotifen 1mg (Zaditen) tablets?
Ketotifen 1mg (Zaditen) Tablets are used to help manage and prevent symptoms caused by allergies and mast cell activation disorders. They are often prescribed for people with conditions like hay fever, allergic rhinitis, and Mast Cell Activation Syndrome (MCAS).
Ketotifen use for Mast Cell Activation Syndrome (MCAS)
Ketotifen is a medication that is often used to help manage symptoms in people with Mast Cell Activation Syndrome (MCAS). MCAS is a condition where mast cells in the body release chemicals too easily, causing a range of symptoms like itching, swelling, stomach pain, headaches, and even severe allergic reactions.
How Ketotifen works
Ketotifen is known as a mast cell stabiliser. This means it helps to stop mast cells from releasing their chemicals (such as histamine) too easily. By doing this, ketotifen can help reduce symptoms like itching, hives, and stomach upset. It also acts as an antihistamine, blocking the effects of histamine—a chemical that causes many allergy symptoms.
Benefits in MCAS
Several studies and case reports suggest that ketotifen can be effective for people with MCAS. It is commonly used when other antihistamines alone are not enough to control symptoms. Ketotifen can be especially helpful for people who experience symptoms in different parts of the body, such as the skin, gut, or respiratory system.
Ketotifen is usually taken as a tablet or syrup, and the dose is adjusted based on how the person responds. It may take a few weeks to notice the full benefits. Some people may experience side effects like drowsiness, dry mouth, or weight gain, but these are generally mild and often improve over time.
References
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Castells, M., & Butterfield, J. (2019). Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management. Journal of Allergy and Clinical Immunology: In Practice, 7(4), 1097-1106.
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Weiler, C. R., Austen, K. F., Akin, C., et al. (2019). AAAAI Mast Cell Disorders Committee Work Group Report: Mast Cell Activation Syndrome (MCAS) Diagnosis and Management. Journal of Allergy and Clinical Immunology, 144(4), 883-896.
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Afrin, L. B. (2013). Presentation, Diagnosis, and Management of Mast Cell Activation Syndrome. Annals of Allergy, Asthma & Immunology, 111(6), 528-536.
What are Ketotifen 1mg (Zaditen) tablets used for?
Ketotifen is mainly used to:
- Prevent and relieve symptoms of allergies, such as runny nose, itchy eyes, sneezing, and skin rashes.
- Help manage symptoms of Mast Cell Activation Syndrome (MCAS), where the body’s mast cells release chemicals too easily, causing allergic-type reactions.
How do Ketotifen 1mg (Zaditen) tablets work?
Ketotifen is both an antihistamine and a mast cell stabiliser:
- Antihistamine: It blocks the effects of histamine, a chemical released during allergic reactions, reducing symptoms like itching and swelling.
- Mast Cell Stabiliser: It helps stop mast cells from releasing their chemicals too easily, preventing allergic reactions before they start.
What are the side effects with Ketotifen 1mg (Zaditen) tablets?
Some side effects can be serious
Stop taking Zaditen tablets and contact your doctor immediately if you notice any of these rare symptoms:
- Severe skin reactions, such as blistering or peeling—these could be signs of an allergic reaction.
- If you have a seizure (fit), tell your doctor straight away.
Other side effects that have been reported include:
- Up to 1 in 10 people: Feeling hyperactive, irritable, or nervous, or having trouble sleeping.
- Up to 1 in 100 people: Cystitis (pain or burning when passing urine), feeling dizzy, or having a dry mouth.
- Up to 1 in 1,000 people: Weight gain or feeling sleepy.
- Very rare (fewer than 1 in 10,000 people): Serious skin reactions (rashes, blistering, or peeling), seizures, or liver problems (including hepatitis or increased liver enzymes, which would show up in a blood test).
Sleepiness, dry mouth, and dizziness usually improve after a few days of taking Zaditen. If any of these symptoms become bothersome, or if you notice anything else unusual, talk to your doctor. They may suggest a different medication for you.
Ketotifen (Zaditen) Tablets – Frequently Asked Questions (FAQs)
What is Ketotifen used for?
Ketotifen is used to help manage and prevent allergic symptoms such as runny nose, itchy eyes, and hives. It is also used to help control symptoms in people with Mast Cell Activation Syndrome (MCAS).
How does Ketotifen help with MCAS?
Ketotifen works as a mast cell stabiliser. This means it helps stop mast cells from releasing chemicals that cause allergic and inflammatory symptoms, making it useful for people with MCAS.
How long does it take for Ketotifen to work?
It may take several days to a few weeks to feel the full effects of Ketotifen. For some people, improvement in symptoms can be noticed sooner.
How should I take Ketotifen tablets?
Ketotifen is usually taken as 1mg (one tablet) twice a day, or as prescribed by your doctor. Swallow the tablet with water, and try to take it at the same times each day.
Can Ketotifen cause drowsiness?
Yes, Ketotifen can make you feel sleepy, especially when you first start taking it. Avoid driving or operating machinery until you know how it affects you.
Are there any side effects of Ketotifen?
Common side effects include drowsiness, dry mouth, dizziness, increased appetite, and sometimes weight gain. Most side effects are mild and may improve over time.
Can I take Ketotifen with other allergy medicines?
You should always check with your doctor or pharmacist before combining Ketotifen with other allergy medicines or antihistamines, as this can increase the risk of side effects like drowsiness.
Is Ketotifen safe for children?
Ketotifen can be prescribed for children, but only under the guidance of a healthcare professional. The dose may be different for children, so always follow your doctor’s instructions.
Can I use Ketotifen if I am pregnant or breastfeeding?
If you are pregnant or breastfeeding, talk to your doctor before using Ketotifen. They will help you decide if it is safe for you.
What should I do if I miss a dose of Ketotifen?
If you miss a dose, take it as soon as you remember. If it’s nearly time for your next dose, skip the missed dose and continue as normal. Do not take two doses at once.
