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Low Dose Naltrexone 1mg/ml solution
from£29.99
Courier Pharmacy’s Low Dose Naltrexone 1mg/ml solution is a specially compounded formulation crafted for convenient and efficient drug delivery. This innovative solution is designed to offer a precise, low-dose treatment option for various conditions.
Uses and Benefits
Commonly used in the treatment of Multiple Sclerosis (MS)
Helps manage various autoimmune diseases
Effective for fibromyalgia, ulcerative colitis, irritable bowel syndrome (IBS), and pain management
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Low Dose Naltrexone, or LDN, is simply a lower dose of the standard naltrexone medication. While regular naltrexone tablets are typically 50mg and used to treat addiction, LDN is specially compounded to deliver doses around 4.5mg, making it suitable for managing conditions like fibromyalgia, where doses between 1mg and 4.5mg are common.
What is the Active Ingredient in Low Dose Naltrexone (LDN)?
Active Ingredient
Low Dose Naltrexone is formulated with naltrexone, available in doses not exceeding 4.5mg.
What is Low Dose Naltrexone (LDN) used for?
Low Dose Naltrexone (LDN) is used off-label to help manage various chronic and inflammatory conditions. It is specially compounded in lower doses compared to standard naltrexone, making it suitable for conditions where immune modulation and reduced inflammation are beneficial.
Common Uses
Autoimmune Diseases LDN is often used to manage conditions like multiple sclerosis (MS), rheumatoid arthritis, lupus, and Hashimoto's thyroiditis by helping to regulate the immune system and lower inflammation.
Chronic Pain Disorders It can be effective in reducing pain and improving quality of life in chronic pain conditions such as fibromyalgia and complex regional pain syndrome (CRPS).
Inflammatory Bowel Diseases LDN shows promise in easing symptoms of Crohn’s disease and ulcerative colitis by reducing inflammation in the gut.
Cancer Some patients use LDN as an additional therapy in cancer treatment to boost the immune system and potentially enhance treatment outcomes, although more research is needed.
Neurological Disorders It is also used in conditions like Parkinson’s disease and Alzheimer’s disease with the aim of slowing disease progression and easing symptoms, though evidence is still emerging.
Irritable Bowel Syndrome (IBS) LDN may help relieve symptoms of IBS, including abdominal pain and irregular bowel movements, by reducing intestinal inflammation.
Safety and Consultation
LDN is generally well-tolerated, but it is important to consult your healthcare provider to ensure it is appropriate for your condition.
How does Low Dose Naltrexone (LDN) work?
Low Dose Naltrexone (LDN) works differently than the standard 50mg dose used for addiction treatment. At lower doses—typically between 0.1mg and 6mg—naltrexone only partially blocks opioid receptors. This partial blockade encourages the body to increase its production of natural endorphins, which can help improve pain relief and modulate the immune system.
Mechanism of Action
At high doses, naltrexone completely blocks opioid receptors, stopping opioid effects. At low doses, it only partially blocks these receptors.
This partial inhibition triggers the body to boost its natural endorphin production, which enhances pain relief.
Additionally, low-dose naltrexone appears to influence the immune system by modulating Toll-Like Receptors (TLRs) on immune cells.
Role of Naltrexone Isomers
Naltrexone comes in two mirror-image forms, known as isomers.
The "levo" isomer primarily acts on opioid receptors, promoting endorphin release.
The "dextro" isomer targets Toll-Like Receptors, helping to reduce the release of pro-inflammatory cytokines.
Together, these actions contribute to both pain relief and a balanced immune response.
Therapeutic Impact
By increasing endorphin levels and reducing excessive inflammation, LDN may help manage various conditions such as chronic pain, autoimmune diseases, and inflammatory disorders.
How do you use Low Dose Naltrexone (LDN)?
Usage Instructions
To use Low Dose Naltrexone (LDN) 1mg/ml solution, begin with a low dose as directed by your healthcare provider. Typically, you start with 1mg and then gradually increase the dose up to a maximum of 4.5mg, based on your individual response and tolerance. Follow your doctor’s guidance carefully to achieve the best results.
Who should not use Low Dose Naltrexone (LDN)?
Avoid Combining with Opiates
Do not use low-dose naltrexone 4.5mg transmucosal buccal film if you are taking any opiates. Although LDN partially blocks opioid receptors, high doses of opiates can still cause serious breathing and circulatory problems, possibly leading to opiate poisoning. Additionally, if you are dependent on opiates, using LDN can trigger severe withdrawal symptoms. Always inform every healthcare provider that you are using this medication. In an emergency where anesthesia is needed, non-opioid alternatives should be used; if opioid-based anesthetics are required, higher doses may be necessary, increasing your risk of side effects.
Liver and Kidney Considerations
Low-dose naltrexone 4.5mg transmucosal buccal film is metabolized by the liver and kidneys. Because individuals with opiate dependence often have liver issues, your doctor will conduct liver function tests before and during treatment.
Interactions with Other Medications
Tell your doctor or pharmacist if you are taking or have recently taken any other medications, including those obtained without a prescription. Some common medicines, such as cough syrups, diarrhea treatments, or pain relievers, may contain opiates and might be less effective while using LDN. In emergency situations, if opioid-containing drugs are necessary, you may require a higher dose for pain relief under close medical supervision due to the risk of increased respiratory depression and other adverse effects.
Food, Pregnancy, and Safety Precautions
Food and drink do not affect the performance of low-dose naltrexone 4.5mg transmucosal buccal film. If you are pregnant, breastfeeding, suspect you may be pregnant, or plan to conceive, consult your doctor or pharmacist before using this medication. LDN should only be used during pregnancy if the benefits outweigh the potential risks, and breastfeeding is not recommended. Also, since LDN may cause drowsiness or reduce alertness, do not drive or operate machinery if you experience these effects.
What are the Side Effects of Low Dose Naltrexone (LDN)?
General Information
Like all medications, low dose naltrexone can cause side effects, though not everyone experiences them. In rare cases, serious effects such as depression, suicidal thoughts, suicide attempts, or hallucinations may occur. If you experience any of these symptoms, contact your doctor or pharmacist immediately.
Side Effects by Frequency
Very Common (more than 1 in 10 patients): Anxiety, insomnia, vivid dreams, headache, restlessness, nervousness, abdominal pain, nausea, vomiting, joint and muscle pain, weakness.
Uncommon (up to 1 in 100 patients): Oral herpes, athlete’s foot, swollen lymph nodes, hallucinations, confusion, depression, paranoia, disorientation, nightmares, agitation, abnormal dreams, shaking, drowsiness, vision problems, eye irritation and swelling, light sensitivity, eye pain or fatigue, eye strain, blood pressure changes, hot flashes, nasal congestion or discomfort, runny nose, sneezing, mouth and throat disorders, excess mucus, sinus issues, voice changes, coughing, shortness of breath, yawning, flatulence, hemorrhoids, ulcers, dry mouth, liver disorders, increased bilirubin, hepatitis, seborrhea, acne, hair loss, itching, groin pain, frequent or painful urination, tinnitus, vertigo, ear pain or discomfort, increased appetite, weight changes, fever, pain, and cold sensations in the extremities.
Rare (up to 1 in 1,000 patients): Reduced platelet count, suicidal thoughts, and suicide attempts.
Very Rare (up to 1 in 10,000 patients): Breakdown of skeletal muscle tissue.
Reporting Side Effects
If you experience any side effects, including those not listed here, speak with your doctor or pharmacist immediately. You can also report side effects through the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for "MHRA Yellow Card" on the Google Play or Apple App Store. Reporting side effects helps improve safety information for this medication.
Does Low Dose Naltrexone (LDN) interact with other medicines?
Inform Your Doctor
Notify your doctor if you are taking, have recently taken, or plan to take any other medications, including over-the-counter products. Some common drugs contain opiates and may not work as intended while you are using low-dose naltrexone.
Medications to Watch
If you need cough syrups, diarrhea medications, or pain relievers, inform your doctor because these might contain opiates.
In emergency situations requiring opioid drugs, higher doses may be necessary for adequate pain relief. This requires close medical supervision due to the increased risk of respiratory depression and other severe side effects.
Low Dose Naltrexone (LDN) FAQs
What is the active ingredient in Low Dose Naltrexone (LDN) 1mg/ml solution?
The key ingredient is naltrexone hydrochloride, with a concentration of 1mg per milliliter.
What is Low Dose Naltrexone (LDN) 1mg/ml solution used for?
Low Dose Naltrexone 1mg/ml solution is commonly prescribed off-label to help manage various conditions. It is used for autoimmune disorders, chronic pain syndromes, and inflammatory conditions due to its immunomodulatory and pain-relieving effects.
How should I take Low Dose Naltrexone (LDN) 1mg/ml solution?
Begin with a low dose, typically 1mg, and gradually increase it as advised by your healthcare provider until you reach a maximum of 4.5mg. Follow your doctor’s instructions closely to ensure the best outcome.
What should I do if I miss a dose of Low Dose Naltrexone (LDN) 1mg/ml solution?
If you miss a dose, take it as soon as you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Do not double up to make up for a missed dose.
What are the potential side effects of Low Dose Naltrexone (LDN) 1mg/ml solution?
Possible side effects include nausea, headache, dizziness, sleep disturbances, and fatigue. If you notice any persistent or worsening symptoms, consult your healthcare provider right away.
Can I drink alcohol while taking Low Dose Naltrexone (LDN) 1mg/ml solution?
It is advisable to avoid alcohol while taking Low Dose Naltrexone, as the treatment is designed to discourage alcohol use and mixing may affect its efficacy.
Can I take Low Dose Naltrexone (LDN) if I am pregnant?
LDN should only be used during pregnancy if absolutely necessary and under strict medical supervision. Discuss the potential risks and benefits with your doctor before starting treatment.
Can I drive or operate machinery while taking Low Dose Naltrexone (LDN) 1mg/ml solution?
Since LDN may cause dizziness or drowsiness, avoid driving or operating machinery until you are certain that the medication does not impair your ability to do so safely.
What should I do in case of an overdose?
If you suspect an overdose and experience severe symptoms such as trouble breathing or loss of consciousness, seek emergency medical assistance immediately.
How should I store Low Dose Naltrexone (LDN) 1mg/ml solution?
Store the solution in the refrigerator to keep it stable and effective. Always follow the storage instructions provided by your pharmacist or healthcare provider.
