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Low Dose Naltrexone 4.5mg Soluble Oral Patch

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Low Dose Naltrexone 4.5mg Transmucosal Buccal Films

Product Overview

Courierpharmacy’s Low Dose Naltrexone 4.5mg transmucosal buccal films are specially compounded for easy and efficient drug delivery.

Common Uses

  • Manage Multiple Sclerosis (MS)
  • Support treatment for various autoimmune diseases
  • Help alleviate fibromyalgia symptoms
  • Assist in treating ulcerative colitis and irritable bowel syndrome (IBS)
  • Provide effective pain management

After completing our online consultation form, you can securely purchase this treatment from courierpharmacy.co.uk.

TREATS:

Fibromyalgia

FORMAT:

Buccal film

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In stock

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Low Dose Naltrexone 4.5mg Soluble Oral Patch
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Additional information

Quantity

1 x 30 films, 2 x 30 films, 3 x 30 films

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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What is Low Dose Naltrexone (LDN)?

Overview

Low Dose Naltrexone (LDN) is a treatment that uses naltrexone at doses much lower than those used for addiction therapy. Standard naltrexone typically comes in high doses to block opioid effects, but LDN is administered in small amounts—usually between 1.5 and 4.5 mg—to help modulate the immune system and reduce inflammation.

How It Works

  • At these low doses, naltrexone does not fully block opioid receptors. Instead, it prompts the body to increase the production of natural endorphins.
  • This boost in endorphins helps regulate immune responses and may decrease inflammation.
  • The overall effect is an improvement in the body’s ability to manage pain and immune-related conditions.

Common Uses

LDN is used off-label to help manage several conditions, including:

  • Autoimmune diseases
  • Chronic pain disorders such as fibromyalgia
  • Multiple sclerosis (MS)
  • Inflammatory conditions like Crohn’s disease and ulcerative colitis

Conclusion

Although the exact mechanism is still under study, LDN is believed to support immune balance and alleviate symptoms in various chronic conditions. Always consult your healthcare provider to determine if LDN is suitable for your needs.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

What is the Active Ingredient in Low Dose Naltrexone (LDN)?

Active Ingredient

The key component is naltrexone, provided in doses up to 4.5mg.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

What is Low Dose Naltrexone (LDN) used for?

Common Uses of LDN

Low Dose Naltrexone (LDN) is used off-label to manage a variety of chronic and inflammatory conditions. It is often recommended when standard treatments do not provide adequate relief. Some of its common uses include:

  • Autoimmune Diseases:
    LDN helps manage conditions such as multiple sclerosis (MS), rheumatoid arthritis, lupus, and Hashimoto's thyroiditis by modulating the immune system and reducing inflammation.

  • Chronic Pain Disorders:
    It is used for conditions like fibromyalgia and complex regional pain syndrome (CRPS) to help reduce pain and enhance quality of life.

  • Inflammatory Bowel Diseases:
    LDN may ease symptoms of Crohn’s disease and ulcerative colitis by lowering gut inflammation.

  • Cancer:
    Some patients use LDN as an adjunct therapy in cancer treatment to support the immune system and potentially improve outcomes, though more research is needed.

  • Neurological Disorders:
    It is sometimes used in conditions like Parkinson’s disease and Alzheimer’s disease to potentially slow disease progression and relieve symptoms.

  • Irritable Bowel Syndrome (IBS):
    LDN can help alleviate IBS symptoms, such as abdominal pain and irregular bowel movements, by reducing inflammation in the intestines.

Consultation and Purchase

LDN is generally well-tolerated, but it is important to consult your healthcare provider to determine if it is right for your condition. After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

How does Low Dose Naltrexone (LDN) work?

Mechanism of Action

At high doses (around 50mg), naltrexone fully blocks opioid receptors to prevent the euphoria associated with opioid use. However, when given at much lower doses (typically between 0.1mg and 6mg), it only partially blocks these receptors. This partial blockade signals the body to boost natural opioid activity, increasing endorphin production and enhancing pain relief.

Immune Modulation

Many chronic conditions stem from immune system imbalances. The rise in endorphins from low-dose naltrexone helps regulate immune responses, reducing inflammation and correcting these imbalances.

Role of Naltrexone Isomers

Naltrexone comes in two mirror-image forms: levo and dextro isomers. The levo form primarily acts on opioid receptors, promoting endorphin release and immune regulation. The dextro form targets Toll-Like Receptors (TLRs), helping to reduce inflammation by decreasing the production of pro-inflammatory cytokines.

Toll-Like Receptors and Inflammation

TLRs are essential for the body's initial defense against infections, triggering inflammation to fight off pathogens. However, overactivation of TLRs can lead to excessive inflammation. By blocking TLR4 receptors, the dextro-naltrexone helps suppress this excessive inflammatory response, which may also ease neuropathic pain.

Conclusion

In summary, low-dose naltrexone works by partially blocking opioid receptors to boost endorphin production, modulating the immune system, and reducing inflammation through its unique isomeric properties. This makes LDN a promising option for managing chronic pain, autoimmune conditions, and inflammatory disorders.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

 
 
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How do you use Low Dose Naltrexone (LDN)?

Usage Instructions

Courierpharmacy’s low dose naltrexone 4.5mg transmucosal buccal film is designed for easy application. Place the film on the inside of your cheek or under your tongue. Thanks to its mucoadhesive properties, it sticks immediately to the lining of your mouth, so you don't need to hold it in place while it dissolves. Avoid swallowing during the dissolution process to ensure the full dose is absorbed through the mucosa and enters your bloodstream for optimal effect. Typically, your naltrexone dose is gradually increased up to 4.5mg, based on your healthcare provider’s guidance, to achieve the desired therapeutic benefit.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

Who should not use Low Dose Naltrexone (LDN)?

Avoid Use with Opiates

  • Do not use low-dose naltrexone 4.5mg transmucosal buccal film if you are taking any opiates. Although LDN partially blocks the effects of opiates, high doses of opiates can still cause severe breathing and circulatory problems, possibly leading to opiate poisoning.
  • If you are dependent on opiates, using LDN may trigger serious withdrawal symptoms.
  • Always inform your healthcare providers that you are using LDN. In emergencies where anesthesia is needed, non-opiate-based anesthetics should be used. If opiate-containing anesthetics are required, higher doses might be needed, increasing the risk of side effects like breathing difficulties.

Liver and Kidney Considerations

  • Low-dose naltrexone 4.5mg transmucosal buccal film is metabolized by the liver and kidneys. Because liver issues are common among individuals with opiate dependence, your doctor will perform liver function tests before and during treatment.

Other Medications

  • Inform your doctor if you are taking or have recently taken any other medications, including those available over the counter. Some common medicines, such as cough syrups, diarrhea treatments, or pain relievers, may contain opiates and might not work effectively while you are using LDN.
  • In emergency situations where opioid drugs are needed, the required dose for pain relief may be higher than usual. Close medical supervision is essential due to the increased risk of respiratory depression and other intensified side effects.

With Food and Drink

  • Food and drink do not interfere with the effects of low-dose naltrexone 4.5mg transmucosal buccal film.

Pregnancy and Breastfeeding

  • If you are pregnant, breastfeeding, suspect you may be pregnant, or are planning a baby, consult your doctor or pharmacist before using LDN. Use during pregnancy should only be considered if the potential benefits outweigh the risks, and breastfeeding is not recommended.

Driving and Operating Machinery

  • Low-dose naltrexone may cause drowsiness or reduced alertness. Do not drive or operate machinery if you experience these effects.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

What are the Side Effects of Low Dose Naltrexone (LDN)?

General Information

Low Dose Naltrexone (LDN) may cause side effects, though not everyone will experience them. Serious side effects such as feelings of depression, suicidal thoughts, suicide attempts, and hallucinations are rare but require immediate medical attention. If you experience any of these symptoms, contact your doctor or pharmacist right away.

Side Effects by Frequency

Very Common (affecting more than 1 in 10 patients)

  • Anxiety
  • Insomnia
  • Vivid dreams
  • Headache
  • Restlessness
  • Nervousness
  • Abdominal pain
  • Nausea
  • Vomiting
  • Joint and muscle pain
  • Weakness

Common (affecting up to 1 in 10 patients)

  • Decreased appetite
  • Heart palpitations
  • Increased heart rate
  • ECG anomalies
  • Libido disorders
  • Thirst
  • Dizziness
  • Excessive tear production
  • Chest pain
  • Diarrhea
  • Constipation
  • Rash
  • Delayed ejaculation
  • Erectile dysfunction
  • Increased energy
  • Irritability
  • Increased sweating
  • Mood disorders

Uncommon (affecting up to 1 in 100 patients)

  • Oral herpes
  • Athlete’s foot
  • Swollen lymph nodes
  • Hallucinations
  • Confusion
  • Depression
  • Paranoia
  • Disorientation
  • Nightmares
  • Agitation
  • Abnormal dreams
  • Shaking
  • Drowsiness
  • Vision problems
  • Eye irritation and swelling
  • Light sensitivity
  • Eye pain or fatigue
  • Eye strain
  • Blood pressure changes
  • Hot flashes
  • Nasal congestion or discomfort
  • Runny nose
  • Sneezing
  • Mouth and throat disorders
  • Excess mucus production
  • Sinus issues
  • Voice changes
  • Coughing
  • Shortness of breath
  • Yawning
  • Flatulence
  • Hemorrhoids
  • Ulcers
  • Dry mouth
  • Liver disorders
  • Increased bilirubin
  • Hepatitis
  • Seborrhea
  • Acne
  • Hair loss
  • Itching
  • Groin pain
  • Frequent urination
  • Painful urination
  • Tinnitus
  • Vertigo
  • Ear pain or discomfort
  • Increased appetite
  • Weight loss or gain
  • Fever
  • Pain
  • Cold sensations in the extremities

Rare (affecting up to 1 in 1,000 patients)

  • Reduced platelet count
  • Suicidal thoughts
  • Suicide attempts

Very Rare (affecting up to 1 in 10,000 patients)

  • Breakdown of skeletal muscle tissue

Reporting Side Effects

If you experience any side effects, including those not listed here, please speak with your doctor or pharmacist immediately. You can also report side effects through the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or by searching for "MHRA Yellow Card" in the Google Play or Apple App Store. Reporting side effects helps improve the safety information for this medication.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

Does Low Dose Naltrexone (LDN) interact with other medicines?

Inform Your Healthcare Provider

Always tell your doctor if you are currently taking, have recently taken, or plan to take any other medications, including over-the-counter ones. Some common drugs may contain opiates and may not work effectively while you are using low-dose naltrexone 4.5mg transmucosal buccal film.

Medication Considerations

If you need cough syrups, diarrhea medications, or pain relievers, let your doctor know, as these might contain opiates. In emergency situations where opioid drugs are necessary, higher doses may be required for effective pain relief. Close medical supervision is essential due to the increased risk of respiratory depression and other intensified side effects.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

Low Dose Naltrexone (LDN) FAQs

What is the active ingredient in Low Dose Naltrexone (LDN) buccal film?

The key ingredient is naltrexone hydrochloride, provided at a dosage of 4.5mg.

What is a Transmucosal Buccal Film?

A transmucosal buccal film is a thin strip containing the active drug. It is designed to stick to the inner cheek or under the tongue and slowly dissolve. This method allows the medication to be absorbed directly into the bloodstream, bypassing the stomach and liver.

How should I take Low Dose Naltrexone 4.5mg Transmucosal Buccal Film?

Apply the film to the inside of your cheek or under your tongue. Thanks to its mucoadhesive properties, it adheres immediately so you do not need to hold it in place. Avoid swallowing while the film dissolves to ensure maximum absorption through the mucosa into the bloodstream.

What should I do if I miss a dose of Low Dose Naltrexone 4.5mg Transmucosal Buccal Film?

If you miss a dose, take it as soon as you remember. However, if your next dose is near, skip the missed dose and continue with your normal schedule. Do not double up to make up for a missed dose.

What are the potential side effects of Low Dose Naltrexone?

Possible side effects include nausea, headache, dizziness, anxiety, tiredness, and sleep disturbances. If these effects persist or worsen, contact your doctor or pharmacist immediately.

Can I drink alcohol while taking Low Dose Naltrexone?

It is recommended to avoid alcohol while on Low Dose Naltrexone, as the medication is designed to discourage alcohol consumption.

Can I take Low Dose Naltrexone if I am pregnant?

Low Dose Naltrexone should only be used during pregnancy if absolutely necessary and under your doctor’s supervision. Discuss the potential risks and benefits with your healthcare provider before use.

Can I drive or operate machinery while taking Low Dose Naltrexone?

Since LDN may cause dizziness or drowsiness, avoid driving or operating machinery until you are sure the medication does not impair your ability to do so safely.

What should I do in case of an overdose?

If you suspect an overdose, particularly if you experience severe symptoms like unconsciousness or difficulty breathing, seek emergency medical help immediately.

Can I stop taking Low Dose Naltrexone abruptly?

Do not stop taking Low Dose Naltrexone without consulting your healthcare provider. Always follow your doctor’s advice regarding any changes to your medication.

After completing our online consultation form, you can securely purchase Low Dose Naltrexone from courierpharmacy.co.uk.

Download patient leaflet

Low Dose Naltrexone Patient Information Leaflet

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Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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18-22 St. Peters Churchyard
Derby DE1 1NN

Pharmacy owner Rapid Medical Solutions Limited, GPhC: 9010051. Prescribing services APC Labs Ltd, Unit 2 Hamble Court Business Park, Hamble Lane, Southampton, SO31 4QL. Dispensing services Courier Pharmacy and APC Labs Ltd. Compounding Services APC Labs Ltd.

Superintendent Pharmacist: Mr. Shazlee Ahsan (GPhC: 2046605)

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