Mysimba weight loss tablets are a prescription medication for adults who are obese or overweight with related health problems. They help reduce appetite and cravings, making it easier to lose weight when combined with a healthy diet and exercise [ 2], [ 3].
Mysimba weight loss tablets are a prescription-only medicine designed to help adults who need extra support managing their weight.
Approved for use in the UK, Mysimba is suitable for people with a body mass index (BMI) over 30. It is also approved for those with a BMI between 27 and 30 who also have weight-related health issues such as:
What sets Mysimba apart from other weight loss tablets is its unique combination of two active ingredients:
naltrexone
bupropion
These medicines work together to help control cravings and reduce appetite. This makes it easier to stick to a healthy eating plan. Mysimba doesn’t work by speeding up your metabolism or blocking fat absorption—it works directly on the brain’s reward and hunger centres [2].
The tablets are taken orally, with a gradual increase in dose over the first few weeks. It will take about eight weeks to notice weight loss effects. However, the full benefits are usually seen by week 16. If you haven’t lost at least 5% of your starting weight by then, your doctor may suggest trying a different approach [1], [ 2], [ 3].
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A complete guide to Mysimba weight loss tablets: what they are, how they work, and why they might be right for you
If you’re searching for a prescription weight loss solution that tackles cravings and supports your journey to a healthier you, Mysimba weight loss tablets could be just what you need. This guide covers what Mysimba is, how it works, who it’s for, and why it could be the missing piece in your weight loss plan.
Key takeaways:
Mysimba weight loss tablets combine two proven medicines to help reduce appetite and cravings.
The treatment is designed for adults with obesity or overweight and weight-related health conditions.
Mysimba is most effective when combined with a healthy diet and regular exercise.
Tablets are taken in gradually increasing doses, under a doctor’s supervision.
This guide covers everything: how to use Mysimba, who it’s for, side effects, and the most common questions.
Overview of Mysimba weight loss tablets
Weight management isn’t just about looking good—it’s about feeling good and reducing your risk of severe health conditions like heart disease, diabetes, and high blood pressure. For many people, losing weight is a real challenge, even with the best intentions and the healthiest of lifestyles. That’s where prescription treatments like Mysimba weight loss tablets come [ 2].
Mysimba is suitable for adults who have struggled to lose weight through diet and exercise alone. It’s not a quick fix or a magic pill, but it can make a real difference for people who are committed to making long-term changes to their eating and activity habits. Clinical trials show that people taking Mysimba, alongside dietary advice and physical activity, are more likely to achieve meaningful weight loss than those who rely on lifestyle changes alone [2], [4].
The medication works best as part of a wider weight management plan, including regular check-ins with your healthcare team. If you stick with it and follow your doctor’s advice, Mysimba can help you achieve—and maintain—a healthier weight [ 3].
Active ingredients in Mysimba weight loss tablets
Each Mysimba weight loss tablet contains two active ingredients: naltrexone and bupropion. Naltrexone helps reduce the desire for food, while bupropion helps you feel fuller and boosts calorie burning. Together, they target the brain’s hunger and reward systems to help you control cravings and eat less [2], [ 3].
What is Mysimba weight loss tablets for?
Mysimba weight loss tablets are designed to help adults who are obese (BMI over 30) or overweight (BMI 27–30 with related health problems) lose weight and improve their overall health. They’re particularly useful for people who have struggled to lose weight through diet and exercise alone or who have health conditions that make weight loss especially important [2].
The tablets are used alongside a reduced-calorie diet and increased physical activity. They’re not suitable for everyone, so your healthcare provider will assess your medical history and current health before prescribing Mysimba [3].
How do Mysimba weight loss tablets work?
Unlike many other weight loss treatments, Mysimba weight loss tablets don’t work by blocking fat absorption or increasing your metabolism. Instead, they work directly on your brain to help control hunger and cravings.
Naltrexone reduces your desire for food, making it easier to resist temptation. Bupropion helps you feel fuller after eating, so you’re less likely to overeat or snack between meals [2], [ 3].
The combination of these two medicines targets multiple pathways involved in appetite and reward, helping you break the cycle of emotional or habitual eating. This makes Mysimba especially helpful for people who struggle with cravings or find it hard to stick to a healthy eating plan [2].
The effects of Mysimba build up gradually over the first few weeks. You start with a low dose and increase it slowly to minimise side effects and give your body time to adjust. Most people begin to notice changes in their appetite and cravings within the first two months [2].
How to use Mysimba weight loss tablets
Taking Mysimba weight loss tablets is straightforward, but it’s important to follow your doctor’s instructions closely.
The tablets are taken by mouth, starting with one tablet in the morning during the first week. The dose is gradually increased each week until you reach the maintenance dose of two tablets in the morning and two in the evening from week four onwards [2].
Always swallow the tablets whole with a glass of water—don’t crush, chew, or split them. It’s best to take Mysimba with food to help reduce stomach upset. Alongside your medication, aim for a balanced, calorie-controlled diet and regular physical activity for the best results [2].
Your doctor will check your progress after 16 weeks. If you haven’t lost at least 5% of your starting weight by then, they may recommend stopping Mysimba and exploring other options [2].
Warnings and precautions before taking Mysimba weight loss tablets
Before starting Mysimba weight loss tablets, it’s important to tell your doctor about any medical conditions you have and all medicines you’re taking. Mysimba is not suitable for everyone and should not be used if you have uncontrolled high blood pressure, a history of seizures, or certain mental health conditions [2].
Avoid drinking alcohol while taking Mysimba, as this can increase the risk of side effects. Mysimba is also not recommended if you’re pregnant, planning to become pregnant, or breastfeeding. Always check with your doctor before starting any new medication [2].
Your doctor will regularly monitor your blood pressure and pulse during treatment. If your blood pressure or pulse stays high, you should stop taking Mysimba [2].
Side effects of Mysimba weight loss tablets
Like all medicines, Mysimba weight loss tablets can cause side effects, although not everyone gets them. The most common side effects are feeling sick, vomiting, constipation, and headaches. These often improve as your body gets used to the medicine [2].
Less common side effects include anxiety, dizziness, difficulty sleeping, altered taste, tiredness, sweating, and skin rash. If you experience any unusual or severe side effects, contact your doctor straight away [2].
Serious side effects, such as seizures, severe allergic reactions, or signs of depression, are rare but require immediate medical attention [2].
Drug interactions
Mysimba weight loss tablets can interact with other medicines, so it’s crucial to tell your doctor about everything you’re taking—including over-the-counter medicines, supplements, and herbal remedies [2].
Do not take Mysimba if you’re already using other medicines containing bupropion or naltrexone, or if you are on MAO inhibitors for depression or Parkinson’s disease. Some medicines for epilepsy, depression, and high blood pressure may also interact with Mysimba [3].
Your doctor will check for any potential interactions and may adjust your treatment plan to keep you safe [3].
Mysimba FAQs
What are Mysimba weight loss tablets?
Mysimba weight loss tablets are a prescription medication for adults who are obese or overweight with related health problems. They help reduce appetite and cravings.
How do Mysimba weight loss tablets work?
They combine two medicines—naltrexone and bupropion—to target the brain’s hunger and reward systems, making it easier to control cravings and feel fuller after eating.
Who can use Mysimba weight loss tablets?
Adults with a BMI over 30, or those with a BMI between 27 and 30 who have weight-related health issues, can use Mysimba if prescribed by a doctor.
How should I take Mysimba weight loss tablets?
Start with one tablet in the morning, then gradually increase the dose as advised by your doctor. Always swallow whole with water and take with food.
What if I miss a dose?
If you miss a dose, skip it and take the next dose at the usual time. Don’t double up.
Can I drink alcohol while taking Mysimba?
It’s best to avoid alcohol as it can increase the risk of side effects.
What are the common side effects?
Feeling sick, vomiting, constipation, headaches, and sometimes anxiety or sleep problems.
Is Mysimba safe for everyone?
No. It’s not suitable for people with uncontrolled high blood pressure, certain mental health conditions, or those who are pregnant or breastfeeding.
How long does it take to see results?
Most people notice changes within eight weeks, but full effects are usually seen by week 16.
Can I buy Mysimba weight loss tablets online?
Yes, after an online assessment and prescription by a registered UK pharmacy like Courier Pharmacy.
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