Sildenafil 100mg Tablets

Quantity	4 tablets, 8 tablets, 16 tablets, 24 tablets, 32 tablets, 64 tablets

What are sildenafil 100mg tablets?

Key takeaways:

Prescribed for men with persistent difficulties achieving or maintaining an erection [1] [2] [3]
Fast-acting ED treatment, usually effective within 30–60 minutes [2] [5]
Lasts up to four hours, supporting natural sexual response [2] [5]
Available as a generic and branded (Viagra) option [2] [3]
Supplied by fully regulated UK online pharmacies, such as courierpharmacy.co.uk.

Sildenafil 100mg tablet is one of the most commonly prescribed medicines for erectile dysfunction in the UK [1].

It’s trusted by NHS clinicians and available from both high street and online pharmacies [2].

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Overview

Sildenafil 100mg tablets work by boosting blood flow to the penis, but only when you’re sexually aroused—so there’s no risk of unwanted effects at awkward moments. For most men, it’s a reliable way to regain confidence and enjoy a healthy sex life.

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How they work

Sildenafil 100mg tablets are a prescribed treatment for erectile dysfunction (ED) in men. They work by blocking phosphodiesterase type 5 (PDE5), an enzyme that normally breaks down cyclic guanosine monophosphate (cGMP)[4].

Higher levels of cGMP help relax smooth muscles and widen blood vessels in the penis during sexual stimulation, which aids in achieving and maintaining an erection.

By preventing the breakdown of cGMP, these tablets improve blood flow to the penis when aroused. This mechanism supports a stronger and more sustainable erection [4].

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Usage guidelines

If you’ve tried lower doses of sildenafil or other ED treatments without success, your doctor might recommend the sildenafil 100mg tablet as the next step.

This dosage of sildenafil is typically recommended for men who have tried the lower doses and did not get a satisfactory erection.
Take one sildenafil 100mg approximately 30 to 60 minutes before sexual activity.
The effects generally last for up to four hours [15].

Buy sildenafil 100mg tablets online in the UK

Buying sildenafil 100mg tablets from courierpharmacy.co.uk means you get a confidential online consultation, fast delivery, and expert pharmacist support whenever you need it.

You’ll also find innovative options, such as compounded buccal films, for men who want extra flexibility or a more tailored approach [14].

What if sildenafil 100mg tablet doesn’t work?

If you’ve tried sildenafil 100mg tablet and it hasn’t delivered the results you hoped for, don’t worry—you’re not out of options. Erectile dysfunction (ED) can be complex, and sometimes it takes a bit of trial and error to find the right solution for you. Here are some next steps and proven alternatives:

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Consider penile injections like Invicorp

One highly effective option is a penile injection called Invicorp. Unlike tablets, Invicorp is injected directly into the side of the penis using a very fine needle. It contains two active ingredients—aviptadil and phentolamine—which work together to relax blood vessels and increase blood flow to the penis, leading to a reliable erection within 5–10 minutes, even without sexual stimulation[16].

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How does Invicorp work?

Invicorp’s unique combination of ingredients works by relaxing the smooth muscle and widening the blood vessels in the penis. This direct mechanism means it often works for men who haven’t had success with oral medications. The injection is quick and typically painless, and most men find it easy to do after a little training from a healthcare professional[16].

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Who is Invicorp for?

Invicorp is especially useful for men who don’t respond to PDE5 inhibitors like sildenafil, or who can’t take them due to other health reasons. It can be used as needed and doesn’t require planning sexual activity around tablets.

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Try the compounded buccal ED film from Courier Pharmacy

If injections aren’t your thing, Courier Pharmacy offers a specially compounded buccal film for ED. This innovative film contains a combination of sildenafil, tadalafil, and L-arginine. You simply place the film inside your cheek, where it quickly dissolves and is absorbed directly through the buccal mucosa.

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Why choose the buccal film?

The buccal film is designed to give you the best of both worlds:

Fast-acting sildenafil provides a quick response, helping you get an erection when you need it.
Long-lasting tadalafil keeps you ready for up to 36 hours, so you don’t have to plan as precisely.
L-arginine is a natural amino acid that supports healthy blood flow.
Buccal absorption means rapid onset and potentially fewer stomach-related side effects.

Why is buccal absorption better than taking tablets orally?

When you take a tablet by mouth, it has to pass through your digestive system and liver before reaching your bloodstream. This process, called “first-pass metabolism,” can reduce how much of the medicine actually gets to where it’s needed and can slow down how quickly it works.
With buccal absorption, the active ingredients are absorbed directly through the lining of your cheek into your bloodstream. This means:

Faster onset of action—you may notice effects sooner.
More consistent absorption—less affected by what you’ve eaten or how your stomach is working.
Potentially fewer gastrointestinal side effects—since less of the medicine passes through your gut.

Who is the buccal film for?

The compounded buccal film is ideal for men who want flexibility and reliability. It’s a great option if you want a discreet, easy-to-use alternative to tablets or if you’ve found that oral medications alone aren’t quite enough.

Next steps

If you’re not getting results with sildenafil 100mg tablet, talk to your healthcare provider or our pharmacy team. They can help you choose the right next step—whether it’s switching to a different medication, trying an injection like Invicorp, or using a compounded buccal film tailored to your needs.

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Boots sildenafil 100mg tablets

Boots is one of the UK’s best-known high street and online pharmacies, and many people turn to them for treatments like sildenafil 100mg tablets. While Boots offers a convenient and reputable service, it’s worth knowing that there are other trusted, fully regulated pharmacies—like Courier Pharmacy—that often provide the same medication at a lower price.

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Why consider Courier Pharmacy or other online options?

Cost savings: Independent online pharmacies frequently offer sildenafil 100mg tablets at a more affordable price point than larger chains, without compromising on quality or safety.
Convenience: You can complete your consultation online and have your medication delivered discreetly to your door—no need to visit a busy high street branch.
Personalised service: Smaller pharmacies like Courier Pharmacy often provide more tailored advice, with access to expert pharmacists and support.
Unique compounded solutions: Courier Pharmacy goes beyond standard treatments by offering innovative compounded medicines, such as buccal ED films that combine sildenafil, tadalafil, and L-arginine. These bespoke options are designed for enhanced flexibility, rapid onset, and improved results for men who need a more tailored approach to ED management.

How are online pharmacies regulated in the UK?

Whether you buy from Boots, Courier Pharmacy, or another provider, it’s essential to know your pharmacy is properly regulated. In the UK, all pharmacies—online or on the high street—must be registered with the General Pharmaceutical Council (GPhC). This ensures:

Strict safety standards: All medicines are sourced from licensed suppliers and dispensed by qualified professionals.
Confidential consultations: Your health information is handled securely and privately.
Clear accountability: Registered pharmacies display their GPhC registration number and can be checked on the GPhC website for peace of mind.

Courier Pharmacy, like all reputable UK online pharmacies, is fully regulated and committed to your safety and privacy. When buying sildenafil 100mg tablets, always check for the GPhC logo and registration details. This way, you can be confident you’re getting genuine medication from a trusted source—at a price that works for you, with the added benefit of unique, innovative treatment options.

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What is the active ingredient in sildenafil 100mg tablets?

The active pharmaceutical ingredient contained in each tablet is 100mg of sildenafil citrate.

This a type of medicine known as a PDE5 inhibitor [2] [3]. This is the same as in Viagra, but you pay less for the generic version. Courierpharmacy.co.uk divider

What are sildenafil 100mg tablets used for?

Sildenafil 100mg tablets are used to treat erectile dysfunction, that is when a man cannot get an erection strong enough for sex [1]. Courierpharmacy.co.uk divider

What is erectile dysfunction?

Sildenafil 100mg tablet is used to treat erectile dysfunction (ED)—that’s when a man can’t get or keep an erection strong enough for sex [1]. ED is more common than you might think, especially as you get older, but it can affect men of any age. Experts predict that by 2025, around 322 million men worldwide might deal with ED [6]. Don’t panic if it happens once in a while—everyone has “off days.” But if it keeps happening for over six months, it’s considered a long-term issue, known as chronic erectile dysfunction [1]. Courierpharmacy.co.uk divider

What causes erectile dysfunction?

ED isn’t just about what’s going on in the moment—it’s often linked to other health problems. For example, conditions like heart disease, high cholesterol, and high blood pressure can make ED more likely [7].

Mental health also plays a big role, with depression being a common factor.

One major cause is diabetes. High blood sugar over time can damage blood vessels and nerves, making it harder to get an erection. This happens because diabetes can lead to something called “endothelial dysfunction.” That’s a fancy way of saying your blood vessels don’t work as well as they should because of the damge caused by the excess sugar in the blood [8].

How clogged arteries affect erections

Your body needs good blood flow to get and keep an erection. But when arteries get clogged or blood pressure is too high, it becomes harder for blood to reach the penis. This is because clogged arteries stop blood vessels from relaxing and widening properly, which is essential for an erection [9].

Think of it this way: if your blood vessels were like a garden hose, clogged arteries would be like a kink in the hose, stopping water (or in this case, blood) from flowing freely.

Erectile dysfunction as an early warning sign

Doctors often say that erectile dysfunction (ED) can be like a warning signal for your overall health. It’s your body’s way of saying, something’s not right with your blood vessels. Research shows that ED can appear about three years before more serious heart problems, like a heart attack or stroke [10].

So, if ED becomes a regular issue, it’s important to take it seriously and check in with a doctor. Early action can help prevent bigger health problems down the line.

Erectile dysfunction is a early warning for heart disease courierpharmacy.co.uk

How sildenafil 100mg can help

If clogged arteries or high blood pressure are affecting your erections, treatments like sildenafil 100mg can help.

Sildenafil works by improving blood flow, helping you get and keep an erection when you’re sexually aroused.

It’s a safe and effective option for many men dealing with ED.

How do sildenafil 100mg tablets work?

Sildenafil belongs to a class of drugs known as phosphodiesterase type 5 inhibitors or PDE5i.

It works by blocking an enzyme called phosphodiesterase type 5 (PDE5), which normally breaks down a chemical messenger called cGMP. Higher levels of cGMP help relax smooth muscles and widen blood vessels in the penis during sexual stimulation, which aids in achieving and maintaining an erection [4] [7].

By blocking this enzyme what sidlenafil basically does is to increase the levels of a chemical called nitric oxide (NO) that is released during sexual stimulation [11].

These increased levels of nitric oxide in turn increases the levels of cyclic guanosine monophosphate (cGMP) in an area of the penis called the corpus cavernosum. The higher cGMP levels relax the smooth muscle cells and dilate the blood vessels in the penis, allowing more blood to flow in and facilitating an erection [12].

However, to really have a good understanding of how sildenafil 100mg works, we need to first know how an erection occurs in the first place.

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How an erection occurs?

An erection happens through a series of chemical signals and processes that help relax the muscles in the penis, allowing blood to flow in and fill the erectile tissue.

The key players in this process are nitric oxide (NO), cGMP (cyclic guanosine monophosphate), and an enzyme called PDE5 (phosphodiesterase type 5) [13].

How an erection occurs, courierpharmacy.co.uk

Here’s how it works in simple terms:

1. Nitric Oxide (NO)

Trigger: When you’re sexually aroused, your body releases nitric oxide (NO) from nerve endings and blood vessel linings in the penis.
Action: NO sends a signal to the smooth muscle cells in the penis, telling them to relax. It does this by activating an enzyme called guanylate cyclase.
Role: NO is the messenger that starts the process of preparing the penis for an erection.

2. cGMP (Cyclic Guanosine Monophosphate)

Production: Guanylate cyclase (activated by NO) produces cGMP, which is like the main worker in this process.
Action: cGMP helps relax the smooth muscles by reducing calcium levels in the cells. This relaxation allows the blood vessels in the penis to widen, letting more blood flow into the erectile tissue. The penis becomes firm as it fills with blood.

3. PDE5 (Phosphodiesterase Type 5)

Role: PDE5 is an enzyme that stops the process by breaking down cGMP. When cGMP levels drop, the blood vessels tighten again, and the erection goes away.
Inhibition: Medications like Sildenafil (Viagra) block PDE5, allowing cGMP to last longer. This keeps the blood vessels relaxed, sustaining the erection.

Summary of the process

Sexual arousal releases nitric oxide (NO).
NO activates guanylate cyclase, which produces cGMP.
cGMP relaxes the smooth muscles, allowing blood to flow into the penis.
PDE5 breaks down cGMP, but medications like Sildenafil stop this breakdown, helping maintain the erection.

A simple analogy: Water and a dam

Think of the penis like a dam and the blood as water:

Nitric Oxide (NO) acts like the signal to open the dam gates.
cGMP is the mechanism that keeps the gates open, allowing water (blood) to flow in and fill the reservoir (the erectile tissue).
PDE5 is like the worker who tries to close the gates too soon. When you take a PDE5 inhibitor like Sildenafil, it stops the worker from closing the gates, allowing the reservoir to fill properly and sustain the erection.

This process only works when there’s sexual arousal—medications like Sildenafil don’t create an erection on their own but help the body’s natural process work more effectively.

How to take sildenafil 100mg tablets?

Take one tablet about 30 to 60 minutes before sexual activity [2].
Swallow whole with water. You can take it with or without food, but a heavy meal may slow it down [5].
Don’t take more than one tablet in 24 hours [2].

If you’re not sure, or have any other questions relating to sildenafil 100mg or erectile dysfunction, please contact us. Courierpharmacy.co.uk divider

Who cannot take sildenafil 100mg tablets?

Sildenafil 100mg tablets are prescribed to treat erectile dysfunction in men. Before starting treatment, your doctor will evaluate your suitability using a consultation or questionnaire. Certain health conditions may require extra assessment or render this medication unsuitable.

Don’t use sildenafil 100mg tablet if you’re taking nitrate medicines (for chest pain) or certain blood pressure medications—this can cause a dangerous drop in blood pressure [2].
Avoid if you have serious heart or liver problems, recent stroke or heart attack, or certain rare inherited eye diseases [2] [3].
Always have a proper health check before starting treatment or complete the online questionnaire to make sure sildenafil is safe for you [1].
If you get an erection that lasts more than four hours (priapism), seek emergency medical help—this is rare, but needs urgent treatment [2].
Tell your doctor about all other medicines and supplements you’re taking—some can interact badly with sildenafil [3].

Contraindicated conditions

Men with the following conditions should avoid taking sildenafil 100mg tablets without further evaluation by their primary care doctor:

Taking nitrate medications (commonly used for chest pain)
Using or planning to use amyl nitrite ("poppers")
Using riociguat for high blood pressure in the lungs
Having low or high blood pressure
Experiencing allergies or reactions to previous ED treatments
A recent heart attack (within the past six weeks), angina, or other heart conditions
A history of strokes or transient ischemic attacks (mini-strokes)
Vision problems caused by circulation issues
A family history of rare degenerative eye diseases
Serious kidney or liver disease
Peyronie’s disease (curvature or deformity of the penis)
Conditions such as leukemia, multiple myeloma, or sickle cell disease
Bleeding disorders like hemophilia
Active stomach ulcers (peptic or gastric ulcers)
Lactose intolerance (as these tablets contain lactose)

Side effects of sildenafil 100mg tablets

Most men have no problems, but like all medicines, sildenafil 100mg tablet can cause side effects [2]. Common side effects:

Headache
Flushing
Indigestion
Nasal congestion
Dizziness
Visual changes

Serious side effects (rare):

Chest pain
Sudden vision loss
Prolonged, painful erection (priapism)

Drug interactions with sildenafil 100mg tablets

Sildenafil 100mg tablets, used mainly for erectile dysfunction, may interact with various other medications [3]. These interactions can change how well sildenafil works or increase the risk of side effects [2]. It is important to tell your doctor about every medication you take, including prescriptions, over-the-counter drugs, and herbal supplements.

Nitrate medications

Examples: Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate
Effect: Can cause a dangerous drop in blood pressure, which may be life-threatening
Advice: Do not use sildenafil with any form of nitrate medication.

Alpha-Blockers

Examples: Doxazosin, tamsulosin
Effect: May lead to a significant drop in blood pressure, causing dizziness or fainting
Advice: Use only under strict medical supervision.

Antihypertensives

Examples: Amlodipine, enalapril
Effect: They can enhance blood pressure-lowering effects, increasing the risk of hypotension
Advice: Regular blood pressure checks are advised.

Protease Inhibitors (for HIV)

Examples: Ritonavir, saquinavir
Effect: Can increase blood levels of sildenafil, which raises the risk of side effects
Advice: Your doctor may need to adjust your sildenafil dose.

Antifungal medications

Examples: Ketoconazole, itraconazole
Effect: May elevate sildenafil levels in your blood
Advice: A dosage adjustment might be necessary.

Antibiotics

Examples: Erythromycin, clarithromycin
Effect: Can increase plasma levels of sildenafil, which may enhance side effects
Advice: Consult with your healthcare provider for potential dose adjustments.

Rifampin (for Tuberculosis)

Effect: Speeds up the metabolism of sildenafil, reducing its effectiveness
Advice: A higher dose of sildenafil might be required.

Other ED medications

Examples: Tadalafil, vardenafil
Effect: Combining these with sildenafil increases the risk of severe side effects such as priapism (a prolonged, painful erection)
Advice: Do not mix different erectile dysfunction treatments without your doctor's guidance and only use specially prepared compounded combination products like the triple combination ED oral patch.

Grapefruit juice

Effect: Can increase the level of sildenafil in your blood, intensifying its effects and side effects
Advice: Avoid consuming grapefruit juice while taking sildenafil.

Alcohol

Effect: May boost the likelihood of side effects like dizziness and further lower blood pressure
Advice: Limit alcohol intake when using sildenafil.

Special considerations

Age and medical conditions: Older adults or those with certain health issues might be more sensitive to drug interactions. Always share your full medical history with your healthcare provider.
Monitoring: Regular monitoring by a doctor is recommended when using sildenafil alongside other medications.
Emergencies: Seek immediate medical help if you experience severe side effects or signs of a serious reaction, such as chest pain, extreme dizziness, or an erection that lasts too long.

Understanding these potential interactions will help you use sildenafil 100mg tablets more safely and effectively. Always consult your healthcare provider for personalized advice.

FAQs about sildenafil 100mg tablets

Why do men experience erectile dysfunction?

Erectile dysfunction (ED), also known as impotence, is a common problem among men. ED can be caused by various factors, including:

Physical Causes:
- Cardiovascular issues (e.g., atherosclerosis, high blood pressure, heart disease) that reduce blood flow to the penis
- Diabetes, which can damage blood vessels and nerves
- Obesity, which often contributes to both heart disease and diabetes
- Hormonal imbalances, such as low testosterone levels
- Neurological conditions like Parkinson’s disease, multiple sclerosis, or spinal injuries
- Certain medications for conditions like high blood pressure or depression may also lead to ED
Psychological causes:
- High levels of stress and anxiety can impair sexual performance
- Depression may lower sexual desire and cause ED
- Relationship problems, including poor communication or unresolved conflicts, can contribute
Lifestyle Factors:
- Smoking can damage blood vessels and limit blood flow
- Excessive alcohol consumption and recreational drug use can interfere with sexual function
- A sedentary lifestyle increases the risk of obesity and cardiovascular issues

If you’re experiencing ED, it is important to talk to your primary care doctor, who can evaluate your condition, conduct necessary tests, and recommend the best treatment option.

Do sildenafil 100mg tablets work every time?

It is advised to try sildenafil 100mg tablets at least four times to assess their effectiveness in treating ED before considering a change in dosage or switching medications.

Keep in mind that ED medications may not work every time or for everyone, as factors like blood flow, sexual arousal, and nerve function play crucial roles.
If ED results from nerve damage due to injury or surgery, these tablets may only offer partial relief, and other treatments such as injections or implants might be required.
For ED with psychological causes, counseling might be a useful addition or alternative to medication.

What are sildenafil 100mg tablets used for?

Sildenafil 100mg tablets are used to treat erectile dysfunction in men. They work by increasing blood flow to the penis during sexual stimulation, which helps in achieving and sustaining an erection. These tablets are available both as the branded version of Viagra and as a generic option, both of which are equally effective.

How should I take sildenafil 100mg tablets?

Take one sildenafil 100mg tablet approximately one hour before sexual activity.
Swallow the tablet whole with water.
The medication can be taken with or without food; however, a high-fat meal might delay its effect.

How often can I take sildenafil 100mg tablets?

Do not take sildenafil 100mg more than once per day. It is important to wait at least 24 hours between doses.

How long does it take for sildenafil 100mg tablets to work?

Sildenafil typically begins working within 30 to 60 minutes after taking the tablet. The effects can last up to four hours, but this does not guarantee an erection for the entire duration.

What are the possible side effects of sildenafil 100mg tablets?

Sildenafil 100mg tablets are generally well tolerated. Common side effects include:

Headache
Flushing
Indigestion
Nasal congestion
Dizziness
Visual disturbances

In rare cases, serious side effects may occur, such as:

Chest pain, which could indicate a heart attack
Sudden vision loss
A prolonged, painful erection (priapism) that requires immediate medical care

Always refer to the patient information leaflet for a complete list of side effects and discuss any concerns with your healthcare provider.

What is the difference between sildenafil and Viagra?

Sildenafil and Viagra work in exactly the same way to treat erectile dysfunction (ED). The key difference is that Viagra is the branded version of sildenafil, first developed by Pfizer. Because it was the first well-known ED treatment, many people still use the name “Viagra” when talking about erectile dysfunction tablets.

Since the original patent expired in 2013, generic sildenafil has become widely available in the UK. It contains the same active ingredient as Viagra, works in the same way, and is just as effective — but is usually much more affordable. This is why many men now choose to buy sildenafil online in the UK as a cost-effective alternative to Viagra.

At Courier Pharmacy, you can order sildenafil tablets online safely, with a quick consultation and discreet delivery.

Can I take sildenafil 100mg tablets with alcohol?

It is best to avoid excessive alcohol consumption when using sildenafil, as alcohol can increase the risk of side effects like dizziness and further lower blood pressure, potentially affecting your ability to achieve an erection.

Is sildenafil as effective as Viagra?

Yes. Sildenafil contains the same active ingredient as Viagra (sildenafil citrate), which means it works in exactly the same way. When Pfizer’s patent for Viagra expired in 2013, other licensed manufacturers were allowed to make generic versions. Because sildenafil is unbranded, it is more affordable, but it’s equally effective.

What brand of sildenafil tablets will I receive?

Different pharmaceutical companies make sildenafil, so the packaging and tablet branding may vary. All versions contain the same active ingredient and are equally effective. If you prefer a particular manufacturer, just let us know at checkout and we’ll make a note for future orders.

Is Viagra stronger than sildenafil?

No. Both Viagra and generic sildenafil come in the same strengths – 25mg, 50mg, and 100mg – and work in the same way to treat erectile dysfunction.

Why is sildenafil cheaper than Viagra?

Viagra is a brand name and carries a higher price because of its reputation. Once the patent expired, other companies began producing generic sildenafil, lowering the cost. Buying sildenafil online is usually cheaper, but the effect is exactly the same as Viagra.

Can I take sildenafil with other medications?

Some medicines should not be taken with sildenafil, including treatments for:

Prostate problems
Chest pain or angina
Seizures

During your consultation, you must declare all medications you are taking. Sildenafil can interact with certain drugs and cause serious side effects. It is especially dangerous to mix sildenafil with recreational drugs such as amyl nitrate (poppers).

Can I take sildenafil with premature ejaculation medication?

No, it is not recommended to combine erectile dysfunction medication with premature ejaculation treatments.

Can I drink alcohol while taking sildenafil?

A small amount of alcohol (such as one glass of wine or beer) is unlikely to cause problems. However, heavy drinking can reduce the effectiveness of sildenafil and increase the risk of low blood pressure, dizziness, or palpitations.

How long does sildenafil take to work?

Sildenafil usually takes 30–60 minutes to start working. For best results, take the tablet on an empty stomach with water, around one hour before sexual activity.

Why might sildenafil not be working for me?

If sildenafil hasn’t worked, it may be due to:

Taking it after a large meal, which slows absorption
Not being aroused (sildenafil only works with sexual stimulation)
Psychological factors such as stress or anxiety

If you continue to have issues, speak to a healthcare professional.

Where can I buy sildenafil?

Sildenafil can be prescribed by your GP, or you can order it safely from a regulated UK online pharmacy after completing a short consultation.

Is it safe to buy sildenafil online?

Yes, as long as you use a regulated UK pharmacy. All medications must be approved by the MHRA (Medicines and Healthcare products Regulatory Agency). Our prescribers only issue treatment if it is safe for you to take.

Do I need a prescription to buy sildenafil online?

Yes. But the process is simple – you’ll complete a confidential online consultation, which is reviewed by a prescriber. If suitable, a prescription will be issued and your treatment will be dispensed and sent to you discreetly.

Is the packaging discreet?

Yes. Orders are delivered in plain, unbranded packaging. Only your name and address will appear on the parcel.

Are there any medications that interact with sildenafil 100mg tablets?

Yes, sildenafil can interact with several other medications, which might alter its effectiveness or increase side effects. These include:

Nitrate Medications: (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate) – can cause a severe drop in blood pressure
Alpha-Blockers: (e.g., doxazosin, tamsulosin) – may lead to significant blood pressure reduction
Antihypertensives: (e.g., amlodipine, enalapril) – can enhance blood pressure-lowering effects
Protease inhibitors (for HIV): (e.g., ritonavir, saquinavir) – may raise blood levels of sildenafil
Antifungal medications: (e.g., ketoconazole, itraconazole) – can increase sildenafil levels in the blood
Antibiotics: (e.g., erythromycin, clarithromycin) – may elevate plasma levels of sildenafil
Rifampin: (an antibiotic for tuberculosis) – can decrease sildenafil’s effectiveness by increasing its metabolism
Other ED medications: (e.g., tadalafil, vardenafil) – combining these increases the risk of severe side effects like priapism
Grapefruit juice: – can increase sildenafil levels, intensifying its effects and side effects

Always inform your healthcare provider about all medications and supplements you are taking.

Can I take sildenafil 100mg if I have a heart condition?

If you have a heart condition, consult your doctor before taking sildenafil. It may not be safe for individuals with certain heart issues.

What should I do if I miss a dose of sildenafil 100mg?

Since sildenafil is taken on an as-needed basis, missing a dose is unlikely. Do not take a double dose to compensate for a missed one.

Can women take Sildenafil 100mg tablets?

Sildenafil is not approved for use in women. Alternative treatments are available for female sexual dysfunction.

What should I do if I experience a prolonged erection?

If you have an erection lasting more than four hours, seek immediate medical attention, as this condition (priapism) can lead to permanent damage.

Can I take sildenafil 100mg with other ED medications?

Do not combine sildenafil with other erectile dysfunction treatments without consulting your doctor, as doing so may increase the risk of severe side effects. However, if you want to combine the effects of sidlenafil and tadalafil, then only use specially compounded preparations, like the triple combination ED film.

How should I store sildenafil 100mg tablets?

Keep the tablets at room temperature, away from moisture and heat, and retain them in their original packaging until ready to use.

What should I do if I overdose on sildenafil 100mg tablets?

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of overdose may include severe dizziness, fainting, or a prolonged erection.

What are PDE5 inhibitors?

PDE5 inhibitors are a group of medications that block the enzyme phosphodiesterase-5 (PDE5), which regulates blood flow in the penis.

By preventing the breakdown of cGMP, these drugs help improve blood flow during sexual arousal, aiding in the achievement and maintenance of an erection.

Besides treating ED, they are also used for conditions like pulmonary arterial hypertension (PAH).

Common examples include sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra). Although these medications are generally well tolerated, they may cause side effects in some individuals and are most effective when combined with lifestyle modifications and counseling.

What is sildenafil 100mg, and how does it work?

Sildenafil 100mg is a medication used to treat erectile dysfunction (ED). It works by increasing blood flow to the penis during sexual stimulation, helping to achieve and maintain an erection.

How long does sildenafil 100mg last?

The effects of sildenafil can last for 4-6 hours, but some effects might linger for up to 24 hours.

Do I need a prescription to buy sildenafil 100mg?

Yes, sildenafil 100mg is a prescription-only medication in the UK or you can buy online by completing the ED health questionnaire.

Can I buy sildenafil 100mg online in the UK?

Yes, you can purchase sildenafil 100mg online from trusted pharmacies like courierpharmacy.co.uk after completing an ED health questionnaire..

What is the difference between sildenafil and Viagra?

Sildenafil is the generic version of Viagra. Both contain the same active ingredient and work in the same way, but sildenafil is often more affordable.

Who can take sildenafil 100mg?

Sildenafil is suitable for adult men aged 18 and over who have erectile dysfunction.

What should I avoid when taking sildenafil 100mg?

Avoid alcohol, grapefruit juice, and fatty meals, as these can reduce the effectiveness of sildenafil.

Can sildenafil be taken with herbal ED remedies?

Ashwagandha is a herbal supplement sometimes used to support men with erectile dysfunction. While it is thought to help reduce stress and anxiety, there is no strong clinical evidence to confirm its effectiveness as a treatment for ED.

At present, no interactions have been identified between sildenafil and ashwagandha. However, if you experience any unwanted side effects when taking them together, you should stop and seek medical advice straight away.

References

NHS (2023) ‘Erection problems (erectile dysfunction)’. Available at: https://www.nhs.uk/conditions/erection-problems-erectile-dysfunction/ (Accessed: 23 September 2025).
EMC (2024) ‘Sildenafil 100mg Tablets - Summary of Product Characteristics (SmPC)’. Available at: https://www.medicines.org.uk/emc/product/7124/smpc (Accessed: 23 September 2025).
BNF (2024) ‘Sildenafil’. Available at: https://bnf.nice.org.uk/drugs/sildenafil/ (Accessed: 23 September 2025).
Corbin JD. Mechanisms of action of PDE5 inhibition in erectile dysfunction. Int J Impot Res. June 2004; 16(1)Suppl 1: S4–7. doi: 10.1038/sj.ijir.3901205, PMID 15224127. https://doi.org/10.1038/sj.ijir.3901205
Medical Mojo. (n.d.) ‘How long does sildenafil last?’ Available at: https://medicalmojo.co.uk/how-long-does-sildenafil-last-for/#h-how-long-does-sildenafil-last (Accessed: 12 April 2025).
Ayta, I. A., McKinlay, J. B., & Krane, R. J. (1999). The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU International, 84(1), 50-56.
Orimoloye, O. A., et al. (2019). Erectile dysfunction and cardiovascular disease: A systematic review and meta-analysis. Journal of the American Heart Association, 8(23), e013006. https://www.ahajournals.org/doi/full/10.1161/JAHA.119.013006
Guay, A. T., et al. (2007). Endothelial dysfunction and erectile dysfunction: The pathophysiological link. Current Sexual Health Reports, 4(1), 47-52. https://link.springer.com/article/10.1007/s11930-007-0008-0
Medical Mojo. (n.d.) ‘Clogged arteries limit blood flow to the penis’. Available at: https://medicalmojo.co.uk/how-long-does-sildenafil-last-for/#h-clogged-arteries-limit-blood-flow-to-the-penis (Accessed: 12 April 2025).
Montorsi, P., et al. (2003). The artery size hypothesis: A macrovascular link between erectile dysfunction and coronary artery disease. The American Journal of Cardiology, 92(9), 19M-23M.
Burnett, A.L., 2006. The role of nitric oxide in erectile dysfunction: implications for medical therapy. The Journal of Clinical Hypertension, 8, pp.53-62. https://onlinelibrary.wiley.com/doi/10.1111/j.1524-6175.2006.05172.x
Lue TF. Erectile dysfunction. N Engl J Med. 2000; 342: 1802–1813. https://www.nejm.org/doi/full/10.1056/NEJM200006153422407
Burnett, A.L., 1997. Nitric oxide in the penis: physiology and pathology. The Journal of urology, 157(1), pp.320-324.
Courier Pharmacy (2024) ‘Sildenafil vs tadalafil: which one is right for you?’ Available at: https://courierpharmacy.co.uk/sildenafil-vs-tadalafil-which-one-is-right-for-you/ (Accessed: 23 September 2025).
Courier Pharmacy (2024) ‘How long does sildenafil last for and how long does it take to work?’ Available at: https://courierpharmacy.co.uk/how-long-does-sildenafil-last-for-and-how-long-does-it-take-to-work/ (Accessed: 23 September 2025).
Medical Mojo (2024) ‘What is Invicorp?’ Available at: https://medicalmojo.co.uk/what-is-invicorp/ (Accessed: 23 September 2025).

Sildenafil 100mg Tablets

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Sildenafil 100mg Tablets: Comprehensive Overview

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Nitrate medications

Alpha-Blockers

Antihypertensives

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1. Nitric Oxide (NO)

2. cGMP (Cyclic Guanosine Monophosphate)