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Zolmitriptan 2.5mg Tablets

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Zolmitriptan is a prescription medication used to treat sudden migraine attacks. It is part of a group of medicines called triptans, which work by narrowing the enlarged blood vessels in the brain that cause migraine pain. Zolmitriptan helps to quickly relieve common migraine symptoms such as headache, nausea, and sensitivity to light and sound. It is usually taken at the start of a migraine or during an episode. Available in tablet form, Zolmitriptan is suitable for adults aged 18 to 65.

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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What is Zolmitriptan 2.5mg?

Zolmitriptan is a medication used to relieve migraines and belongs to the triptan class of drugs. Available in film-coated tablets, it works by targeting the blood vessels in the brain. Migraines are often caused by the dilation of these blood vessels, and Zolmitriptan helps reduce this by narrowing them. This action helps relieve the headache and other symptoms like nausea, vomiting, and sensitivity to light and sound. It’s important to remember that Zolmitriptan is designed to treat an active migraine, not prevent future attacks.

What is the active ingredient in Zolmitriptan 2.5mg?

The active ingredient in each Zolmitriptan tablet is Zolmitriptan 2.5 mg.

What is Zolmitriptan 2.5mg used for?

Zolmitriptan 2.5mg is used to treat migraines once they begin. It belongs to the triptan family of drugs and works by narrowing the blood vessels in the brain that often expand during a migraine. This helps reduce symptoms like headaches, nausea, and sensitivity to light and sound. Zolmitriptan 2.5mg should be taken as soon as migraine symptoms start for relief, but it does not stop future migraines from happening.

How does Zolmitriptan 2.5mg work?

Zolmitriptan 2.5mg works by targeting the causes of a migraine to provide relief. Specifically:

  • Vessel Constriction: As a triptan, Zolmitriptan binds to serotonin receptors in the brain, helping to narrow the blood vessels that expand during a migraine, which reduces the headache.

  • Chemical Stabilization: It helps balance certain brain chemicals involved in the migraine process, decreasing the inflammation and disturbances that contribute to symptoms.

  • Symptom Relief: By addressing both the blood vessel and chemical causes, Zolmitriptan helps reduce migraine symptoms like headache, nausea, and sensitivity to light and sound.

Zolmitriptan 2.5mg works best when taken early in the onset of migraine symptoms. It helps relieve symptoms during an attack but does not prevent future migraines.

How to Use Zolmitriptan 2.5mg

It’s important to follow your doctor’s or pharmacist’s advice when using Zolmitriptan 2.5mg tablets. If you’re unsure about anything, ask them for guidance.

  • Timing: Take Zolmitriptan as soon as you notice a migraine headache or when the attack begins.

  • Dosage: The usual starting dose is one 2.5 mg or 5 mg tablet.

  • Administration: Swallow the tablet with water.

  • Additional Dose: If the migraine persists after two hours or comes back within 24 hours, you can take a second tablet. Do not take more than your prescribed dose.

Important Notes:

  • Maximum Daily Dose: You should not take more than two doses in one day unless advised by your doctor. The maximum daily dose is 10 mg.

  • Elderly Adults: Zolmitriptan is not recommended for people over 65.

  • Children and Adolescents: It is not suitable for individuals under 18 years old.

What to Do If You Take Too Much:
If you accidentally take more than the prescribed dose, contact your doctor or go to the nearest hospital immediately. Bring the medication with you.

What to Do If You Miss a Dose:
If you miss a dose, do not take a double dose. Simply take your next dose as scheduled.

For any additional questions about using Zolmitriptan, speak to your doctor or pharmacist.

Who Should Not Use Zolmitriptan 2.5mg?

Zolmitriptan 2.5mg tablets should not be used if:

  • You are allergic to zolmitriptan or any of its ingredients (check the patient information leaflet).
  • You have high blood pressure.
  • You have a history of heart issues, including heart attacks, angina (chest pain from exertion), Prinzmetal's angina (resting chest pain), or symptoms like shortness of breath or chest pressure.
  • You’ve had a stroke or transient ischaemic attack (TIA), which are similar to strokes.
  • You are currently using other migraine treatments such as ergotamine, dihydroergotamine, methysergide, or other triptans. See the section on 'Other medicines and Zolmitriptan' for more information.

If any of these conditions apply to you, do not take Zolmitriptan 2.5mg. Speak to your doctor or pharmacist if you are unsure.

Warnings and Precautions

Before using Zolmitriptan 2.5mg, consult your doctor or pharmacist if:

  • You are at risk for ischaemic heart disease (poor blood flow to the heart). Risk factors include smoking, high blood pressure, high cholesterol, diabetes, or a family history of ischaemic heart disease.
  • You have Wolff-Parkinson-White Syndrome (a type of irregular heartbeat).
  • You have or have had liver problems.
  • Your headaches feel different from your usual migraines.
  • You are taking medications for depression. See the 'Other medicines and Zolmitriptan' section for details.
  • You are using herbal remedies like St John’s Wort (used for depression).
  • You are going to a hospital; inform the medical staff that you are taking Zolmitriptan 2.5mg.

Zolmitriptan 2.5mg is not recommended for people under 18 or over 65 years old.

Overuse Risks

Taking too much Zolmitriptan 2.5mg can lead to daily headaches or worsen your migraines. If you think you may have this issue, speak to your doctor, as you may need to stop using the medication.

Food and Drink

Zolmitriptan 2.5mg can be taken with or without food, as it does not affect how the medication works.

Pregnancy, Breastfeeding, and Fertility

Please consult your doctor for advice regarding Zolmitriptan if you are pregnant, breastfeeding, or planning to become pregnant.

What Are the Side Effects of Zolmitriptan 2.5mg?

Like any medication, Zolmitriptan 2.5mg can cause side effects, but not everyone will experience them. Some side effects may be linked to the migraine itself.

Seek immediate medical help if you experience any of the following rare or very rare side effects:

Rare Side Effects (affecting up to 1 in 1,000 people):

  • Allergic reactions, such as itching, rash (urticaria), or swelling of the face, lips, mouth, tongue, or throat.

Very Rare Side Effects (affecting up to 1 in 10,000 people):

  • Chest pain (angina), heart attack, or blood vessel spasm in the heart, which may include chest pain and shortness of breath.
  • Spasms of the blood vessels in the gut, possibly causing stomach pain or bloody diarrhea.
  • Bleeding in the brain (cerebral bleeding) or stroke.

Other Possible Side Effects:

Common Side Effects (affecting up to 1 in 10 people):

These are usually mild and often resolve on their own.

  • Abnormal sensations, like tingling in fingers and toes or sensitive skin.
  • Drowsiness, dizziness, or feeling warm.
  • Headache.
  • Irregular heartbeat.
  • Nausea or vomiting.
  • Stomach pain.
  • Dry mouth.
  • Muscle weakness or pain.
  • General weakness.
  • Sensations of heaviness, tightness, pain, or pressure in the throat, neck, arms, legs, or chest.
  • Difficulty swallowing.

Uncommon Side Effects (affecting up to 1 in 100 people):

  • Rapid heartbeat.
  • Slight increase in blood pressure.
  • Increased urine output or frequency.

Very Rare Side Effects (affecting 1 in 10,000 people):

  • Sudden, urgent need to urinate.

Reporting Side Effects:

If you notice any side effects, including those not listed here, contact your doctor or pharmacist. You can also report side effects through the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. Reporting side effects helps provide more information about the safety of this medication.

Does Zolmitriptan 2.5mg Interact with Other Medicines?

It’s important to inform your doctor or pharmacist if you are taking, have recently taken, or plan to take any other medications, including over-the-counter products or herbal remedies.

Medications for Migraine:

  • If you are taking another triptan (like sumatriptan or naratriptan), you should wait 24 hours before using Zolmitriptan 2.5mg.
  • After taking Zolmitriptan, wait 24 hours before using another triptan.
  • If you are using ergotamine or ergot-type drugs (e.g., dihydroergotamine or methysergide), wait 24 hours before taking Zolmitriptan.
  • After taking Zolmitriptan, wait 6 hours before using ergotamine or similar medications.

Medications for Depression:

  • Monoamine Oxidase Inhibitors (MAOIs), such as moclobemide.
  • Selective Serotonin Reuptake Inhibitors (SSRIs), like fluoxetine, paroxetine, fluvoxamine, or sertraline.
  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), like venlafaxine or duloxetine.

Other Medications:

  • Cimetidine (for indigestion or stomach ulcers).
  • Quinolone antibiotics (such as ciprofloxacin).

Herbal Remedies:

  • St John’s Wort (Hypericum perforatum) may interact with Zolmitriptan. Discontinue use and notify your doctor if you experience any issues.

If you are unsure about potential interactions, consult your doctor or pharmacist before taking Zolmitriptan 2.5mg.

Zolmitriptan 2.5mg FAQs

What is Zolmitriptan and what is it used for?

Zolmitriptan 2.5 mg Tablets are used to treat migraine attacks. The active ingredient, zolmitriptan, belongs to a group of medications known as triptans. These are designed to relieve migraine symptoms by reducing the inflammation of blood vessels in the brain. Each pack contains 6 tablets and is available by prescription for adults between the ages of 18 and 65.

What is a migraine?

In the UK, migraines affect around 25% of women and 8% of men. They can be genetic, meaning if someone in your family has them, you may be more likely to experience them. Common triggers for migraines include poor diet, excessive alcohol, too much caffeine, stress, lack of sleep, or menstrual cycles. Migraines can cause severe disruptions with symptoms like nausea, light sensitivity, intense throbbing pain, and heightened intolerance to noise and smells. A migraine can last anywhere from a few hours to three days, with fatigue often lingering for days afterward.

How does Zolmitriptan work?

Zolmitriptan works by targeting the widening of blood vessels in the brain, which is believed to cause the pain of a migraine. As a serotonin agonist, it stimulates serotonin receptors to narrow the blood vessels, which helps relieve pain. For best results, take Zolmitriptan as soon as you feel a migraine starting or during an attack. While it doesn’t prevent migraines, it can be used alongside other treatments for prevention.

What are some alternative over-the-counter medications for migraines?

Some over-the-counter treatments for migraine pain and nausea include:

  • Paracetamol
  • Ibuprofen
  • Aspirin
  • Migraleve

For more details on treatment options, visit our Advice for Migraines page.

What should I know about taking Zolmitriptan?

Always follow your doctor’s or pharmacist’s guidance when taking Zolmitriptan. It should be taken as soon as you feel a migraine start or during an attack. The usual dose is one 2.5 mg tablet with water. If symptoms persist after two hours or return within 24 hours, you may take a second tablet. Do not take more than two doses in one day, with a maximum daily dose of 10 mg.

What are the ingredients in Zolmitriptan?

Each Zolmitriptan tablet contains 2.5 mg of zolmitriptan. The other ingredients are lactose anhydrous, microcrystalline cellulose, sodium starch glycolate type A, magnesium stearate, hypromellose, titanium dioxide (E 171), macrogol 400, macrogol 8000, and iron oxide yellow (E172).

What side effects might I experience with Zolmitriptan?

Common side effects, which are usually mild and temporary, include tingling sensations, drowsiness, dizziness, feeling warm, headache, irregular heartbeat, nausea, vomiting, stomach pain, dry mouth, muscle weakness, and sensations of heaviness or pressure. If you notice any of these or other concerning symptoms, speak to your doctor or pharmacist.

What warnings should I be aware of before taking Zolmitriptan?

Do not take Zolmitriptan if you are allergic to it or any of its ingredients, have high blood pressure, or have a history of heart problems or stroke. Avoid using it with other migraine medications, such as ergotamine or other triptans. Talk to your doctor if you smoke, have high cholesterol, diabetes, a family history of heart disease, liver issues, or are using antidepressants or herbal remedies with St John’s Wort.

What should I know about Zolmitriptan during pregnancy and breastfeeding?

If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor or pharmacist before taking Zolmitriptan, as its effects during these times are not well understood. Always read the packaging and Patient Information Leaflet for guidance and inform your doctor about any other medications you are using.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.9924.pdf

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Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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