Hydroxyzine 25mg tablets are a fast-acting antihistamine used to relieve itching, anxiety, and MCAS. They’re available on prescription after completing an online questionnaire and undergoing a clinical review.
Hydroxyzine 25mg tablets are a prescription-only antihistamine used to treat a range of conditions, including itchy skin, allergies, and MCAS. Unlike many modern antihistamines, hydroxyzine is a “first-generation” antihistamine, which means it can also make you feel quite drowsy.
You might be prescribed hydroxyzine 25mg tablets if you’re dealing with persistent itching, hives, or MCAS. It’s a reliable medicine that’s been trusted by doctors and patients for decades.
Here’s what makes hydroxyzine different:
It works quickly—often within 30 minutes.
It has a calming, sedative effect (helpful for night-time symptoms).
It’s suitable for both adults and children (with adjusted dosing).
Hydroxyzine 25mg tablets are available from licensed UK pharmacies, such as Courier Pharmacy, after a quick online consultation. They’re dispensed by pharmacists who check your suitability and provide guidance on safe use [1][2].
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1 x 28 tablets, 2 x 28 tablets, 3 x 28 tablets
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Everything you need to know about hydroxyzine 25mg tablets—how they work, who they’re for, and how to use them safely.
Hydroxyzine 25mg tablets: a trusted antihistamine for allergy and itch relief, anxiety, and mast cell activation syndrome (MCAS).
Easy-to-understand guide, with practical tips and original insights.
Clear answers on dosage, side effects, and drug interactions.
Friendly, expert-backed advice you can trust.
All information referenced from the electronic Medicines Compendium (EMC) and British National Formulary (BNF).
Overview: hydroxyzine 25mg tablets
Hydroxyzine 25mg tablets have been used in the UK for decades to help people manage allergies, itching, and MCAS. They’re part of a group of medicines known as first-generation antihistamines, which means they can cause drowsiness [1].
The medicine works by blocking the action of histamine—a chemical your body releases during allergic reactions. By stopping histamine, hydroxyzine helps reduce itching, swelling, and other allergy symptoms.
Hydroxyzine is a prescription-only medicine in the UK. That means you need a clinical review before you can get it. At Courier Pharmacy, you can complete a simple online questionnaire to check if hydroxyzine is right for you. Our pharmacists review your answers, check for any risks or interactions, and make sure you get safe, effective treatment [2].
Active ingredient: hydroxyzine 25mg tablets
The active ingredient in hydroxyzine 25mg tablets is hydroxyzine hydrochloride. Each tablet contains 25mg of hydroxyzine hydrochloride, which is responsible for the medicine’s antihistamine, anti-itch, and calming effects [1][2].
What is hydroxyzine 25mg tablets for?
Hydroxyzine 25mg tablets are used to treat several different conditions:
Allergic skin reactions: Such as hives (urticaria), eczema, and other itchy rashes.
MCAS: Hydroxyzine is sometimes prescribed for mast cell activation syndrome.
Doctors may also use hydroxyzine for other reasons, such as helping with sleep or as part of a treatment plan for severe allergies [1][2].
How do hydroxyzine 25mg tablets work?
Hydroxyzine is an antihistamine, which means it blocks the effects of histamine—a chemical your body releases during allergic reactions. When histamine is active, it causes symptoms like itching, swelling, and redness. By stopping histamine, hydroxyzine helps calm these symptoms down [1].
Hydroxyzine starts working within about 30 minutes, with its maximum effect in around two hours. The calming and anti-itch effects can last for several hours, making it a good option for nighttime symptoms [2].
How to use hydroxyzine 25mg tablets
Take as prescribed: Always follow your doctor’s instructions. For most adults, hydroxyzine 25mg tablets are taken at night, but your dose and timing may vary.
Swallow whole with water: You can take hydroxyzine with or without food. Try to take it at the same time each day for the best results.
Don’t exceed the dose: If you miss a dose, take it as soon as you remember—unless it’s close to your next dose. Never take two doses together. If you accidentally take too much, seek medical help right away [1][2].
Initially 25 mg daily, dose to be taken at night; increased if necessary to 25 mg 3–4 times a day.
Warnings and precautions: hydroxyzine 25mg tablets
Hydroxyzine 25mg tablets aren’t suitable for everyone. Tell your doctor or pharmacist if you:
Have ever had an allergic reaction to hydroxyzine, cetirizine, or similar medicines.
Have heart problems, especially a history of abnormal heart rhythm (QT prolongation).
Have liver or kidney disease, epilepsy, or are elderly (as you may be more sensitive to side effects).
Hydroxyzine can cause drowsiness and affect your ability to drive or operate machinery. Wait to see how it affects you before doing anything that requires full concentration.
If you’re pregnant or breastfeeding, hydroxyzine is not recommended. Always check with your healthcare provider before starting any new medicine [1][2].
For a full list of the contraindiactions to hydroxyzine 25mg, please consult the patient information leaflet.
Side effects: hydroxyzine 25mg tablets
Like all medicines, hydroxyzine 25mg tablets can cause side effects, although not everyone gets them. The most common are:
Drowsiness or feeling sleepy (especially at the start of treatment)
Dry mouth, headache, or dizziness
Stomach upset, constipation, or nausea
Rarely, hydroxyzine can cause serious side effects like allergic reactions, heart rhythm problems, or confusion (especially in older adults). If you notice chest pain, palpitations, fainting, or severe rash, stop taking hydroxyzine and seek medical attention immediately [1].
Most side effects are mild and improve as your body gets used to the medicine. If you’re worried about any symptoms, talk to your pharmacist or doctor [2].
For a complete list of the side effects, please consult the patient information leaflet.
Drug interactions: hydroxyzine 25mg tablets
Hydroxyzine can interact with other medicines, so always tell your healthcare provider about everything you’re taking. Important interactions include:
Other sedating medicines: Such as sleeping pills, tranquillisers, or strong painkillers—these can increase drowsiness.
Medicines that affect heart rhythm: Including some antibiotics, antidepressants, and antipsychotics. Combining these with hydroxyzine can increase the risk of heart problems.
Alcohol: Drinking alcohol while taking hydroxyzine can make you extra sleepy or confused.
If you’re taking any medicines for allergies, anxiety, depression, or heart problems, check with your pharmacist before starting hydroxyzine [1][2].
For the complete list of drug interactions with hydroxyzine 25mg, please refer to the patient information leaflet.
FAQ: hydroxyzine 25mg tablets
How quickly do hydroxyzine 25mg tablets start working?
Hydroxyzine typically begins to take effect within 30 minutes and reaches its maximum effect in approximately two hours. You should notice relief from itching or anxiety fairly quickly.
Can I take hydroxyzine 25mg tablets with other antihistamines?
It’s best to avoid combining antihistamines unless your doctor specifically tells you to. Taking more than the recommended amount can increase side effects, such as drowsiness or dry mouth.
Is hydroxyzine 25mg tablets safe for children?
Hydroxyzine can be used in children, but the dose is lower and based on weight. Always follow your doctor’s instructions for children’s dosing.
Can I drive after taking hydroxyzine 25mg tablets?
Hydroxyzine can make you feel sleepy or less alert. Wait to see how it affects you before driving or operating machinery.
What should I do if I miss a dose?
Take the missed dose as soon as you remember, unless it’s nearly time for your next one. Don’t double up. If you’re unsure, ask your pharmacist.
Are there foods or drinks I should avoid?
Avoid alcohol and grapefruit juice while taking hydroxyzine, as these can increase side effects or change how the medicine works.
Can I take hydroxyzine 25mg tablets if I’m pregnant or breastfeeding?
Hydroxyzine is not recommended during pregnancy or breastfeeding. Speak to your doctor for safer alternatives.
What are the signs of an allergic reaction to hydroxyzine?
Seek urgent help if you notice swelling of the face or throat, severe rash, trouble breathing, or fainting. These could be signs of a serious allergic reaction.
How should I store hydroxyzine 25mg tablets?
Store in a cool, dry place away from children. Don’t use after the expiry date on the pack.
How do I get hydroxyzine 25mg tablets from Courier Pharmacy?
Complete our quick online questionnaire. A pharmacist or prescriber will review your answers to make sure hydroxyzine is safe and right for you. If approved, your medicine is delivered discreetly and quickly.
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