How long does tadalafil  20mg last after taking it?

Let’s face it—when it comes to treating erectile dysfunction (ED), timing is everything. Whether you’re planning a romantic dinner or want to be prepared for when the moment strikes, knowing how long tadalafil 20mg lasts is crucial. After all, you don’t want to be left wondering if the clock is ticking while you’re still waiting for the magic to happen.

Tadalafil 20mg, often nicknamed the “weekend pill” for its long-lasting effects, offers flexibility and convenience that other erectile dysfunction medications can’t quite match. With the potential to last up to 36 hours, it’s like having a VIP pass to spontaneity. But how does it work, when’s the best time to take it, and how long does tadalafil 20mg last after taking it? All of these questions and more will be answered in this guide.

Key points about tadalafil 20mg

1. One tablet can last up to 36 hours
2. Effects start within 30 minutes to 2 hours
3. Daily doses of tadalafil 5mg can provide continuous effectiveness

What is erectile dysfunction?

Before diving into the specifics of when to take tadalafil 20mg or Cialis 20mg, it’s important to understand the basics of erectile dysfunction (ED).

Erectile dysfunction, commonly referred to as ED, is defined as the inability to achieve or maintain an erection firm enough for penetrative sex [1]. The occasional performance issue usually is not a cause for concern; everyone can have a bad day at the office. However, persistent erectile difficulties lasting for six months or more, is classified as chronic erectile dysfunction, may be caused by serious underlying health issues, such as heart disease.

What is tadalafil?

Tadalafil, also known by its brand name Cialis, was initially developed as a heart medication. However, during clinical trials, researchers discovered its potential to improve erections, shifting its focus from cardiovascular health to erectile dysfunction treatment [2].

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor, which targets an enzyme that breaks down a chemical messenger called cyclic guanosine monophosphate (cGMP) [3]. It belongs to the same class of medications as sildenafil (Viagra) and vardenafil (Levitra).

How does tadalafil 20mg work?

Tadalafil works by increasing the cGMP levels in the body, allowing blood vessels to relax and widen [4]. This enhanced blood flow to the penis helps achieve and maintain an erection.

How does tadalafil increase cGMP levels? It blocks the enzyme PDE5, which is responsible for breaking down cGMP. This means that cGMP levels rise since it is no longer being broken down. When GMP levels remain high, they prolong the dilation of blood vessels and improve blood flow. Essentially, tadalafil competes with cGMP for the binding site on PDE5, tricking the enzyme into thinking it’s cGMP  [3].

However, it’s important to note that tadalafil doesn’t cause an automatic erection. Sexual arousal is still required to trigger the release of nitric oxide, which initiates the production of cGMP. Without sexual stimulation, tadalafil will not be effective [5].

How long does tadalafil 20mg last after taking it?

The duration of tadalafil depends on the dosage and method of use:

• As-needed doses (tadalafil 10mg or tadalafil 20mg):
  The effects of Tadalafil can last up to 36 hours, providing a wider window of opportunity for sexual activity. This extended duration allows for a more natural and stress-free experience  [6].
• Daily doses (tadalafil 2.5mg or tadalfil 5mg):
  With daily dosing, tadalafil remains consistently active in your system, allowing you to achieve an erection anytime without the need for pre-planning  [7].

Both options offer unique benefits, allowing you to choose the approach that best suits your routine and preferences.

When does tadalafil 20mg start working?

The onset of tadalafil depends on the dosage and how it’s prescribed:

• As-needed doses (tadalafil 10mg or tadalafil 20mg):
  Tadalafil 20mg typically begins working within 30 minutes to 2 hours after taking the tablet [8], [9]. This makes it an ideal choice for individuals who prefer flexibility and the ability to plan around sexual activity. However, if taken with a heavy or high-fat meal, its onset may be delayed [10].
• Daily doses (tadalafil 2.5mg or tadalafil 5mg):
  The onset is more gradual for those on a daily regimen. It may take several days of consistent use to achieve full effectiveness. Tadalafil stays in the body for a long time (about 17.5 hours), making it ideal for daily use. Taking it every day helps maintain steady levels in the blood, reaching full effect within five days. Daily use builds up tadalafil in the system, so a 2.5 mg dose acts like 4 mg, and a 5 mg dose works like 8 mg over time  [7]. Once established, this option allows for spontaneity, as you won’t need to plan ahead [11].

Regardless of the dosage, sexual stimulation is required for tadalafil to work effectively.

What affects how long tadalafil 20mg works?

Several factors can influence the duration and effectiveness of tadalafil:

1. Age: Older individuals may metabolise the medication more slowly, which can prolong its effects [12].
2. Health conditions: Liver or kidney issues can affect how tadalafil is processed, potentially extending its duration or requiring dose adjustments [12].
3. Diet: While tadalafil can be taken with or without food, a heavy or high-fat meal may delay its onset  [10].
4. Alcohol consumption: Excessive alcohol can impair the medication’s effectiveness and your ability to achieve an erection [13].
5. Other medications: Some drugs, including nitrates and blood pressure medications, can interact with Tadalafil, affecting its safety and performance [12].

Always consult your healthcare provider for personalised advice to maximise its benefits and minimise risks.

Timing your tadalafil dose for best results

Timing is key to getting the most out of Tadalafil:

• As-needed doses (tadalafil 10mg or tadalafil 20mg):
  Take the tablet 30 minutes to 2 hours before sexual activity. While it can be taken with or without food, a heavy meal may slow its absorption  [10].
• Daily Doses (tadalafil 2.5mg or tadalafil 5mg):
  Take your dose at the same time every day to maintain consistent levels in your system. Timing is less critical with this option, as it provides continuous coverage.

Remember, sexual stimulation is necessary for tadalafil to work, regardless of the dosing method.

Understanding the ’36-Hour’ window

The term “36-hour window” refers to tadalafil’s extended duration of effectiveness, not a continuous erection. After taking an as-needed dose, tadalafil 20mg remains active in your system for up to 36 hours. This flexibility allows for spontaneity, making it a popular choice for those who prefer a more natural experience.

It’s important to note that tadalafil 20mg doesn’t cause automatic or prolonged erections. Instead, it enhances blood flow to the penis when stimulated, making it easier to achieve and maintain an erection naturally.

Factors to consider when taking tadalafil

• Timing: Plan your dose to align with your lifestyle and preferences.
• Health conditions: Discuss any medical conditions with your healthcare provider to ensure safe use.
• Interactions: Be mindful of other medications or lifestyle factors that may affect tadalafil’s performance.

Introducing  the UK’s first triple combination erectile dysfunction soluble oral patch

For men seeking a more advanced and convenient solution to erectile dysfunction, the Triple Combination Erectile Dysfunction Soluble Oral Patch provides a revolutionary option. These films combine sildenafil, tadalafil, and L-arginine in a soluble oral patch that is absorbed directly through the mouth’s mucosa.

Key features of the Triple Combination Erectile Dysfunction Soluble Oral Patch

1. Rapid absorption: The patch is placed inside the mouth, either under the tongue or against the cheek, allowing the active ingredients to enter the bloodstream quickly.
2. Fast action: Effects can begin within 30 minutes.
3. Long-lasting: The films provide effectiveness for up to 36 hours, offering the confidence of Tadalafil’s extended duration.
4. Multiple Strength Options: Available in Low Strength, Medium Strength, and High Strength, these options ensure flexibility to suit individual needs.

The combination of sildenafil’s rapid onset and tadalafil’s long-lasting action makes these films perfect for men seeking both spontaneity and reliability.

Why choose the Triple Combination Erectile Dysfunction Soluble Oral Patch?

Unlike traditional tablets, the films bypass the digestive system, ensuring faster and more effective results. They are particularly beneficial for men who want to avoid the timing challenges of oral tablets or those who experience delayed absorption due to heavy meals.

Explore the range:

For more information, on how to use the soluble oral patch, watch the video below.

Start your ED treatment today.

At Courier Pharmacy, we offer discreet and convenient access to tadalafil. Begin your journey with a quick and confidential online consultation—it only takes a few minutes.

If you are concerned about erectile dysfunction and would like to speak to one of our specialists, please contact us for a FREE men’s health consultation.

Disclaimer: This article is for informational purposes only and does not replace professional medical advice.

References:

1. Muneer, A., Kalsi, J., Nazareth, I., & Arya, M. (2014). Erectile dysfunction. BMJ, 348, g129.
2. Medical Mojo (2025) When to take Tadalafil? Available at: https://medicalmojo.co.uk/when-to-take-tadalafil/#h-what-is-tadalafil-or-cialis (Accessed: 20 March 2025).
3. Francis SH, Corbin JD. Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists. Curr Urol Rep. 2003;4:457–65.
4. Corbin, J.D., & Francis, S.H. (2004). Pharmacology of phosphodiesterase-5 inhibitors. International Journal of Clinical Practice, 58(4), 363-369.
5. Andersson, K.E., & Mulhall, J.P. (2018). Mechanisms of penile erection and basis for pharmacologic treatment of erectile dysfunction. Urologic Clinics of North America, 45(2), 147-157. Available at: https://doi.org/10.1016/j.ucl.2017.12.001
6. Medical Mojo. “How Long Does Tadalafil Last After Taking It?” Available at: https://medicalmojo.co.uk/how-long-does-tadalafil-last-after-taking-it/
7. Forgue ST, Patterson BE, Bedding AW, et al. Tadalafil pharmacokinetics in healthy subjects. Br J Clin Pharmacol. 2006;61:280–8.
8. Ahsan, S. (2025) ‘How long does sildenafil last for and how long does it take to work?’, Courier Pharmacy, 18 March. Available at: https://courierpharmacy.co.uk/how-long-does-sildenafil-last-for-and-how-long-does-it-take-to-work/ (Accessed: 20 March 2025).
9. Medical Mojo (2025): How long does Tadalafil last after taking it? Available at: https://medicalmojo.co.uk/how-long-does-tadalafil-last-after-taking-it/#h-how-soon-does-tadalafil-start-to-work (Accessed: 20 March 2025).
10. Medical Mojo (2025) How long does Tadalafil last after taking it? Available at: https://medicalmojo.co.uk/how-long-does-tadalafil-last-after-taking-it/#h-tadalafil-and-fatty-meals (Accessed: 20 March 2025).
11. Medical Mojo (2025) When to take Tadalafil? Available at: https://medicalmojo.co.uk/when-to-take-tadalafil/#h-what-is-tadalafil-daily (Accessed: 20 March 2025).
12. Medical Mojo (2025) How long does Tadalafil last after taking it? Available at: https://medicalmojo.co.uk/how-long-does-tadalafil-last-after-taking-it/#h-factors-that-can-affect-how-long-tadalafil-works (Accessed: 20 March 2025).
13. Medical Mojo (2025): Can I drink alcohol while taking Sildenafil? Available at: https://medicalmojo.co.uk/can-i-drink-alcohol-while-taking-sildenafil/ (Accessed: 20 March 2025).

Special offer

Are weight loss treatments making you tired, or have they led to a sudden increase in hair loss? Do you struggle with sleep?

Get a free month’s supply of one of our compounded treatments for energy, hair loss or sleep, with your first purchase of Mounjaro or Wegovy from Courier Pharmacy.

Claim your FREE offer