Psoriasis affects around 2-3% of UK adults — roughly 1.5 to 2 million people. After all, plaque psoriasis isn’t just a skin condition; it’s a long-term inflammatory disease that affects quality of life, mental health, work, relationships, and confidence. So when patches flare, good treatment matters. However, ointments often feel greasy and impractical to use during the day.
Enstilar bridges that gap. Specifically, the same combination of calcipotriol and betamethasone that worked in Dovobet ointment is here delivered in a clean foam format. As a result, patients typically see clear improvement within the first 1-2 weeks. In addition, the unique approval for twice-weekly upkeep means Enstilar can stay part of a long-term plan after the initial 4-week course.
Where Enstilar fits in psoriasis treatment
The UK approach to plaque psoriasis follows a stepped path:
Step 1: Emollients (moisturisers) used regularly — for everyday skin care and reducing scale
Step 2: Single-active topical treatments — such as vitamin D analogues (Dovonex) or topical corticosteroids alone
Step 3: Combined topical treatments — for example Enstilar foam, Dovobet ointment, or Dovobet gel
Step 4: Coal tar products (Exorex, Psoriderm, Alphosyl) — older but still useful
Step 6: Light therapy under specialist supervision
Step 7: Whole-body treatments (methotrexate, ciclosporin, acitretin) — for severe psoriasis
Step 8: Biologic medicines (Stelara, Cosentyx, Taltz, Tremfya) — for severe psoriasis under specialist care
Step 9: Combined approaches — usually managed by a skin specialist
So Enstilar sits at Step 3 — combined topical therapy. In short, it’s a sensible step when single-active topical treatments haven’t been enough, while light therapy or whole-body options haven’t yet been needed.
Enstilar foam vs Dovobet ointment
Different formats, same actives:
Enstilar foam: clean, easy-to-apply aerosol foam
In contrast, Dovobet ointment is a traditional greasy ointment base
Same active ingredients (calcipotriol 50mcg/g + betamethasone 0.5mg/g) in both
So Enstilar is less greasy and easier to apply during the day
In addition, Enstilar penetrates skin better due to supersaturation
However, Dovobet ointment has a better moisturising effect on very dry plaques
Also, Enstilar is approved for twice-weekly upkeep; Dovobet ointment is not
Both apply once daily for the initial 4-week course
In general, choice often comes down to skin type, area being treated, and personal preference
Enstilar foam vs Dovobet gel
The PSO-ABLE clinical trial comparison:
Enstilar foam: aerosol foam with supersaturated active ingredients
In contrast, Dovobet gel is a lighter gel base
Same active ingredients in both
However, the PSO-ABLE trial showed Enstilar foam was MORE effective than Dovobet gel at 4 weeks
So this isn’t just personal preference — there’s clinical evidence of superiority
Also, Enstilar is approved for twice-weekly upkeep; Dovobet gel is not
In general, Dovobet gel may suit patients who don’t want an aerosol product
Enstilar vs calcipotriol alone (Dovonex)
Single-active vs combined:
Dovonex (calcipotriol alone, 50mcg/g): slower onset, fewer side effects
In contrast, Enstilar (calcipotriol + betamethasone) has faster onset and stronger initial effect
While Dovonex usually applies twice daily, Enstilar applies once daily
So Dovonex suits mild psoriasis or upkeep after Enstilar
However, Enstilar suits moderate psoriasis or initial control
In general, many patients use Enstilar for active flares and twice-weekly upkeep
Enstilar vs topical steroid alone
Single-active steroid vs combined:
Betamethasone alone (Diprosone, Betnovate): fast inflammation control
However, Enstilar adds calcipotriol’s effect on skin cell overgrowth to the same steroid action
So a steroid alone may control symptoms, although it doesn’t address the deeper skin cell turnover
In addition, there’s a risk of rebound flare when steroid is stopped suddenly
Also, long-term steroid alone carries more risk of skin thinning
In general, Enstilar’s combined approach is preferred for plaque psoriasis
Enstilar vs Otezla and biologics
Topical vs whole-body treatment:
Enstilar: topical foam, applied to skin only
In contrast, Otezla (apremilast) is an oral tablet for moderate to severe psoriasis
Biologics (Stelara, Cosentyx, Taltz, Tremfya): injectable medicines for severe psoriasis
However, Enstilar suits mild to moderate psoriasis amenable to topical treatment
So biologics and oral treatments suit severe or treatment-resistant psoriasis
Also, biologics often need specialist input and ongoing monitoring
In general, Enstilar is sometimes added on alongside biologics for stubborn patches
Who Enstilar foam suits well
This product may suit:
Adults with stable plaque psoriasis on the body or scalp
Patients who prefer a less greasy format
Patients with hard-to-reach areas like the back or scalp
Patients who want cosmetically acceptable daytime treatment
Patients suited to a long-term upkeep approach (twice-weekly use)
Patients who’ve tried Dovobet ointment and found it too greasy
Patients who’ve responded to combination therapy before
Patients managing psoriasis between specialist appointments
Adults who can use aerosol products safely
Who might suit other options better
Other options may suit better for:
Children and adolescents — Enstilar isn’t licensed for under-18s in the UK
People with erythrodermic psoriasis (widespread redness)
People with exfoliative psoriasis (widespread skin shedding)
People with pustular psoriasis (pus-filled spots)
People with guttate psoriasis (small drop-like spots)
People with known calcium balance problems
People with severe liver or kidney problems
People who can’t use aerosol products (safety reasons, environments with flames)
People who can’t use steroid-based products
People with known allergy to vitamin D analogues, corticosteroids, or any ingredient
Pregnant women — talk to your GP first
Breastfeeding women — talk to your GP first
Patients with psoriasis covering more than 30% of body surface area — since whole-body treatment usually fits better
Patients with mostly facial or genital psoriasis — since a different treatment usually fits better
Patients with very dry plaques — since the more moisturising Dovobet ointment may suit better
Courier Pharmacy supply
Enstilar foam is a UK Prescription-Only Medicine (POM). So supply only happens after our UK-qualified prescriber reviews your situation through an online consultation. In short, if our prescriber decides another approach would suit better — for example emollients, single-active treatments, ointment or gel format, or skin specialist referral — we’ll explain that clearly.
Key features and specs
Active ingredients per gram: calcipotriol 50 micrograms (as monohydrate) and betamethasone 0.5mg (as dipropionate)
Form: white to off-white cutaneous aerosol foam
Pack size: 60g pressurised aluminium can (other sizes may be available)
Initial dose: apply once daily to affected areas for up to 4 weeks
Upkeep dose: twice weekly after initial response (approved long-term use)
Maximum daily dose: 15g per day
Maximum body surface area: 30%
Age range: adults (18+ in the UK)
Total weekly maximum: 100g (initial), much lower with twice-weekly upkeep
Storage: do not store above 30°C; pressurised container — flammable
Don’t expose to temperatures above 50°C even when empty
Legal status: Prescription-Only Medicine (POM)
Maker: LEO Pharma
Related products in family: Dovobet ointment, Dovobet gel (scalp), Dovonex (calcipotriol alone)
Additional information
Quantity
1 x 60g, 2 x 60g
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Enstilar Foam — Modern Foam Treatment for Plaque Psoriasis
Enstilar Foam delivers two well-established psoriasis actives in a clever aerosol foam format. So each gram contains calcipotriol 50 micrograms (a vitamin D analogue) and betamethasone dipropionate 0.5mg (a potent corticosteroid) — the same combination as Dovobet ointment, but in a much less greasy form. As a result, the foam sprays on cleanly, absorbs quickly, and leaves little residue. Important: Enstilar is a UK Prescription-Only Medicine (POM) for adults with stable plaque psoriasis. So treatment is typically once daily for the first 4 weeks, with twice-weekly upkeep allowed after that. Made by LEO Pharma. Note: this is an aerosol product — flammable, so use away from flames.
At Courier Pharmacy, we believe in treatment that fits the person.
This page covers what Enstilar is, who it suits, how the foam format compares to ointment and gel versions, the unique twice-weekly upkeep approach, and the practical points that matter.
Five key takeaways
Enstilar is a UK Prescription-Only Medicine (POM). So supply only happens after our UK-qualified prescriber reviews your situation through an online consultation
Two actives in foam form: calcipotriol 50mcg/g (vitamin D analogue) that calms skin cell overgrowth, plus betamethasone dipropionate 0.5mg/g (potent corticosteroid) that reduces inflammation and itch. After all, the same combination as Dovobet — just in a cleaner, easier-to-apply foam
Initial treatment: once daily for up to 4 weeks. So this matches the Dovobet ointment schedule. However, Enstilar is also approved for twice-weekly upkeep after the initial 4-week course — a unique advantage backed by the PSO-LONG long-term trial
PSO-ABLE clinical trial showed Enstilar foam was MORE effective than Dovobet gel at the same 4-week point. In short, the foam format isn’t just more convenient — it actually penetrates better and works faster
Important practical points: aerosol product (don’t use near flames), shake before use, hold can upright when spraying, maximum 15g per day, maximum 30% body surface area. Also avoid the face, skin folds, and genital area unless your prescriber says otherwise
Why choose Courier Pharmacy for Enstilar
At Courier Pharmacy, our approach starts with a simple idea: treatment should fit the person, not force the person to fit the system.
Dr Ada Jex-Cori
Our service is shaped by the philosophy of Dr Ada Jex-Cori, our brand pharmacist.
Dr Ada represents the spirit of the pharmacy: evidence-led, community-rooted, and willing to challenge the one-size-fits-all approach to medicine. She is named in honour of three pioneering women in science: Ada Lovelace, the mathematician and visionary; Sophia Jex-Blake, the first female doctor in the UK who fought the medical establishment; and Gerty Cori, the biochemist and Nobel Prize winner.
In our fictional world of Etherwell, Dr Ada fights against pharma’s standardised approach to medicine. In the real world, she represents what we stand for. Her view is straightforward: you are not broken. The system is. And we are here to change that.
Skin conditions deserve serious attention
Psoriasis is often dismissed as “just a skin condition.” Courier Pharmacy is different. So we recognise that:
Psoriasis is a long-term inflammatory disease, not just a cosmetic issue
It affects quality of life, mental health, work, relationships, and confidence
People with psoriasis face increased risk of cardiovascular disease, depression, and psoriatic arthritis
Visible patches can affect what people wear, where they go, and how they feel about themselves
Effective treatment makes a real difference to daily life
Patients often feel dismissed by clinicians who don’t understand the impact
After all, psoriasis affects around 2-3% of UK adults — millions of people. So our prescriber takes the condition seriously.
Format matters as much as molecule
The Enstilar foam vs Dovobet ointment choice isn’t trivial:
Same actives, same dose — but different practical experience
Ointment suits very dry plaques and overnight use
Foam suits daytime use, hairy areas, and patients who dislike greasy textures
Foam actually penetrates better (PSO-ABLE study showed foam superior to gel)
Foam is approved for twice-weekly upkeep; ointment is not
Our prescriber can discuss which format suits your situation
In short, the right format makes treatment easier to stick with — and Enstilar’s foam delivers genuine clinical benefits beyond just convenience.
Honest framing about the twice-weekly upkeep advantage
Enstilar has something most topical psoriasis treatments don’t:
Approved for proactive upkeep after the initial 4-week course
PSO-LONG trial showed 52 weeks of twice-weekly use extended remission
This changes psoriasis management from reactive (treating flares) to proactive (preventing flares)
Not all patients need this approach — some flare rarely and can manage with intermittent courses
Patients with frequent flares often benefit most from the twice-weekly approach
Our prescriber will discuss whether the upkeep approach suits your situation
Honest framing about long-term steroid use
Enstilar contains a potent steroid — and that matters:
Used in the recommended schedule (daily for 4 weeks, then twice weekly), side effects are manageable
PSO-LONG showed good safety over 52 weeks of twice-weekly use
“Steroid phobia” is common but often disproportionate to actual risk with foam at twice-weekly intervals
Our prescriber will discuss realistic risk-benefit balance for your situation
Long gaps between applications (twice weekly) reduce cumulative steroid exposure
Don’t use other topical steroids on the same area while using Enstilar
Psoriasis and the bigger picture
Psoriasis isn’t just a skin condition. So our pharmacist can discuss:
Psoriatic arthritis and joint pain that often accompanies psoriasis
Mental health support — depression and anxiety are common with psoriasis
Cardiovascular health — psoriasis is associated with raised cardiovascular risk
Trigger identification — stress, infections, certain medicines, alcohol
Diet and inflammation — some patients find dietary changes help
Smoking cessation — smoking worsens psoriasis
Vitamin D status — important for skin health generally
Sometimes the visible patches are the visible part of a wider picture worth talking through.
Pharmacist support before and after purchase
Our pharmacist is here to discuss:
Whether Enstilar is the right product for your psoriasis stage
Proper foam application technique
Which areas to treat and which to avoid
How to switch from initial daily use to twice-weekly upkeep
How to combine with emollients and other skin care
Aerosol safety considerations
Signs of overuse to watch for
When to seek additional medical input
This is free and on hand before and after purchase.
Trust earned, not claimed
We are GPhC-regulated, and our content is grounded in the BNF, NICE Clinical Knowledge Summary on psoriasis, British Association of Dermatologists guidance, NHS guidance, the PSO-FAST and PSO-LONG clinical trials, and the real experience of patients managing long-term plaque psoriasis.
If Enstilar isn’t the right answer for your situation, we’ll tell you honestly. After all, getting the right treatment matters more than fulfilling a request.
How to buy Enstilar from Courier Pharmacy
Enstilar foam is a UK Prescription-Only Medicine (POM). So supply needs a prescription, which our prescriber issues after an online consultation.
How our service works
Add Enstilar to your basket and complete the online consultation
The consultation covers your psoriasis history, current symptoms, areas affected, previous treatments, current medicines, and relevant medical history
Our UK-qualified prescriber reviews your answers to confirm whether Enstilar is suitable
Our prescriber may request photos of affected areas or recent dermatology notes
If a different approach would suit better — emollients, single-active treatments, ointment or gel format, or specialist referral — we’ll get in touch
Once approved, your prescription is dispensed and sent out in plain, discreet packaging
Free pharmacist and prescriber support is on hand before and after your purchase
When other options might suit better
If Enstilar isn’t right, we’ll explain why. Other options may include:
Emollients (Doublebase, Cetraben, Diprobase, Epaderm) — first-line for everyone with psoriasis
Dovonex (calcipotriol alone) — for milder psoriasis or upkeep
Topical corticosteroids alone (Diprosone, Betnovate, Eumovate) — for short-term inflammation control
Dovobet Ointment — for very dry plaques where moisturising helps
Dovobet Gel — for scalp psoriasis specifically
Coal tar preparations (Exorex, Psoriderm, Alphosyl)
Dithronol (Micanol, Dithrocream)
Salicylic acid preparations for thick scaly plaques
Tacalcitol (Curatoderm) or calcitriol (Silcis) — alternative vitamin D analogues
Light therapy referral — for widespread or treatment-resistant psoriasis
Whole-body treatments (methotrexate, ciclosporin, acitretin) under specialist care
Biologic medicines (Stelara, Cosentyx, Taltz, Tremfya) under specialist care
Specialist dermatology referral for treatment-resistant or complex psoriasis
Our community service
Our free fortnightly drop-in clinics at Insomnia, Derby run every other week from 10am to 12pm.
Healthcare shouldn’t only happen when you’re paying for it. So we show up, even when it’s free.
We cover psoriasis, eczema, acne, hair loss, MCAS, menopause, men’s and women’s health, digestive health, ADHD, autism support, allergies, asthma, weight management, and whatever else people bring through the door. No appointment needed, no charge, no pressure.
Active ingredients
Each gram of Enstilar Foam contains:
Calcipotriol 50 micrograms (as monohydrate): a synthetic vitamin D analogue
Betamethasone 0.5mg (as dipropionate): a potent topical corticosteroid
Why calcipotriol
Calcipotriol is a synthetic version of vitamin D made specifically for psoriasis:
Binds to vitamin D receptors in skin cells (keratinocytes)
Slows the rapid overgrowth of skin cells in psoriasis plaques
Helps skin cells mature normally rather than building up as thick scales
Doesn't affect calcium balance significantly when used as directed
Doesn't cause the skin thinning seen with long-term steroid use
Can be used long-term with appropriate medical monitoring
In short, calcipotriol addresses the root cause of plaque psoriasis — skin cells multiplying too fast. After all, the silvery-white scales aren't a layer added on top of the skin; they ARE the skin, made too rapidly and not maturing properly.
Why betamethasone dipropionate
Betamethasone is a potent corticosteroid (Group III/IV strength):
Reduces inflammation by suppressing immune activity in the skin
Reduces redness, swelling, and warmth
Reduces the itching that often comes with psoriasis
Acts quickly — usually within the first few days of treatment
Gives immediate symptom relief while calcipotriol works on the deeper problem
Belongs to the same family as Diprosone and Betnovate
After all, the inflammation of psoriasis isn't just uncomfortable. So calming inflammation matters as much as treating the skin cell overgrowth.
Why the foam format matters
Enstilar's foam isn't just a cosmetic upgrade — it's a clever delivery system:
Supersaturated formulation — the actives are held in solution at concentrations higher than normally stable
Once sprayed, the solvents evaporate, leaving a highly concentrated layer of active on the skin
This enhances penetration through the outer skin layer
Better skin penetration means more active reaches its targets
As a result, faster onset of action than with ointment or gel
Foam spreads easily and absorbs quickly
Less greasy residue means easier to use during the day
Good for hard-to-reach areas like the back, or hairy areas like the scalp
In short, the foam isn't just about how it feels — it actually works better. So in the PSO-ABLE clinical trial, Enstilar foam was MORE effective than Dovobet gel at the same 4-week point.
Why combination therapy works
The two actives complement each other:
Calcipotriol alone (Dovonex): effective but slow — improvement over weeks
Topical steroid alone (Diprosone, Betnovate): fast inflammation control but doesn't address skin cell overgrowth
Enstilar combined: both effects in one application
Faster initial improvement than calcipotriol alone
Better long-term control than steroid alone
Once-daily dosing is more practical than separate twice-daily products
Each ingredient may slightly reduce side effects of the other
In short, combination therapy isn't just convenience — it's actually more effective.
The unique upkeep advantage
Enstilar has something Dovobet ointment doesn't:
Approved for both initial daily treatment AND ongoing twice-weekly upkeep
Based on the PSO-LONG trial — a 52-week study of long-term proactive use
Twice-weekly use after initial response keeps psoriasis under control
Extends time to first flare significantly
Reduces number of flares over a year
Increases days in remission
Generally well-tolerated over 52 weeks
So this means Enstilar can be used as a long-term management tool, not just a flare treatment
After all, psoriasis is a long-term condition — and proactive upkeep is often more useful than waiting for the next flare. So the twice-weekly approach genuinely changes how patients can manage their psoriasis.
Other ingredients
Enstilar foam also contains:
Butylated hydroxytoluene (BHT, antioxidant)
Liquid paraffin
Polyoxypropylene-11-stearyl ether
Alpha-tocopherol (vitamin E, antioxidant)
Dimethyl ether (propellant)
Butane (propellant)
Notably, Enstilar uses dimethyl ether and butane as propellants. So the can is pressurised and flammable — don't use near naked flames, lit cigarettes, or other sources of ignition. Also, don't puncture or burn the can, even when empty.
Pack details
Enstilar comes in specific can sizes:
60g pressurised aluminium can with white plastic actuator
Some markets also offer 120g cans
Foam is white to off-white
Aerosol format with directional spray
Don't refill, puncture, or expose to high temperatures
Maker
Enstilar is made by LEO Pharma — a Danish dermatology specialist founded in 1908. So LEO has a long-established psoriasis portfolio, including the original Dovonex (calcipotriol alone), Dovobet ointment and gel (the same combination in earlier formats), and Enstilar foam (the newer aerosol formulation). Enstilar was first approved in the US in 2015 and in the UK and Europe in 2016.
What is Enstilar for?
Enstilar treats stable plaque psoriasis — the most common form of psoriasis. So this is the type with well-defined, raised, red patches covered with silvery-white scales, most often on the elbows, knees, lower back, scalp, and other parts of the body. The foam addresses both the rapid skin cell overgrowth and the inflammation behind the visible changes. As a result, regular use over 4 weeks typically clears or hugely reduces scale, redness, and itch.
Who is it for?
Enstilar may suit:
Adults with stable plaque psoriasis on the body or scalp
Patients who prefer a less greasy format than ointment
Patients with hairy or hard-to-reach areas (back, scalp)
Patients managing flares between specialist appointments
Patients on a long-term upkeep schedule with twice-weekly use
Patients who've used Dovobet ointment or gel and found them too greasy or hard to apply
Patients who want cosmetically acceptable daytime treatment
Adults who can use aerosol products safely
What does it do?
Enstilar tackles two main drivers of plaque psoriasis at the same time. First, calcipotriol — a vitamin D analogue — slows the rapid overgrowth of skin cells (keratinocytes) that creates the thick, scaly patches. Second, betamethasone dipropionate — a potent corticosteroid — reduces the inflammation, redness, swelling, and itching that come with psoriasis. So combining both actives in one foam means fewer applications and better results than either alone.
In addition, Enstilar's foam vehicle has a clever extra trick. Specifically, the formulation is supersaturated — the actives are held in solution at concentrations higher than would normally be stable. As a result, the actives penetrate the skin faster and more deeply than with the same actives in ointment or gel form.
What it doesn't do
Enstilar doesn't cure psoriasis. So psoriasis is a long-term condition — the foam manages flares and supports upkeep, although it doesn't permanently fix the underlying immune balance. In addition, Enstilar isn't suitable for all psoriasis types (no use in erythrodermic, exfoliative, or pustular psoriasis). However, the same foam is approved for both initial treatment and ongoing twice-weekly upkeep, which gives it more flexibility than ointment or gel.
How Enstilar works
Enstilar delivers two complementary mechanisms in one foam. So understanding what each inredient does — and why the foam format matters — helps explain why it works better than the same actives in other formats.
How calcipotriol works
Calcipotriol acts on vitamin D receptors in skin cells:
Penetrates the outer skin layer (stratum corneum)
Binds to vitamin D receptors on keratinocytes (skin cells)
Triggers gene expression changes inside the cells
Slows the rapid division of skin cells in psoriasis plaques
Encourages skin cells to mature properly
Reduces the build-up of immature, scaly cells on the surface
Has some immune-modulating effects locally in the skin
In short, calcipotriol addresses the deeper problem — skin cells dividing too fast.
How betamethasone dipropionate works
Betamethasone is a potent corticosteroid:
Penetrates skin and enters cells
Binds to glucocorticoid receptors inside cells
Reduces production of inflammatory chemicals (cytokines, prostaglandins)
Suppresses immune cell activity in the skin
Reduces blood vessel widening (less redness)
Reduces nerve signalling that causes itch
Effects start within hours of application
How the foam format enhances penetration
This is Enstilar's clever trick:
The foam contains the actives in a supersaturated state
Supersaturation means concentrations higher than would normally be stable
After spraying, the solvent base (propellants) evaporates quickly
This leaves a highly concentrated layer of active on the skin
More active is available at the skin surface to penetrate
Deeper penetration means more active reaches its targets
So the foam delivers more drug to the right place than ointment or gel of the same actives
After all, this is why the PSO-ABLE trial showed Enstilar foam was MORE effective than Dovobet gel. So the foam format isn't just easier to apply — it actually works better.
The PSO-LONG trial findings
The 52-week study that established twice-weekly upkeep:
Patients first received daily Enstilar for 4 weeks
Responders were then randomised to twice-weekly Enstilar or vehicle alone
Twice-weekly Enstilar significantly extended time to first flare
Reduced number of flares over 52 weeks
Increased days in remission
Well-tolerated with no new safety signals over 52 weeks
Skin thinning rates were low and similar to vehicle
Calcium balance remained normal
In short, this is the evidence that supports using Enstilar as a long-term management tool. So instead of waiting for flares, patients can use the foam twice weekly to prevent them.
What happens during a 4-week course
Typical response pattern:
Days 1-7: Reduction in redness and itch (mostly from betamethasone)
Weeks 2-3: Scale reduction builds up (calcipotriol effect)
Week 4: Maximum benefit typically reached
After 4 weeks: medical review needed
If responded well — option to continue with twice-weekly upkeep
If partial response — discuss next steps with prescriber
If poor response — discuss alternative treatments
How to use Enstilar foam
This summary is for reference only. The definitive guide is the patient information leaflet supplied with the can. So if anything isn't clear, contact our pharmacist or prescriber.
Standard application
How to apply Enstilar:
Wash your hands thoroughly with soap and water
Shake the can vigorously for a few seconds before each use
Hold the can upright with the nozzle pointing at the affected area, about 3cm from the skin
Press the spray head to release a small amount of foam directly onto the plaques
Don't spray directly on the face
Gently rub the foam in until it disappears
Wash your hands after applying (unless treating your hands)
Apply once daily for the initial 4-week course
After successful response, switch to twice-weekly upkeep if your prescriber agrees
Where to apply (and where not to)
Suitable areas:
Trunk (chest, back, abdomen)
Arms and legs
Elbows and knees (common psoriasis sites)
Lower back
Scalp (where the foam format is particularly good)
Stick to prescribed amounts and treatment durations
The pustular psoriasis warning
Important warning about stopping treatment:
Abruptly stopping after long continuous use can occasionally trigger pustular psoriasis
Pustular psoriasis is a more severe form with pus-filled spots
This is part of why the 4-week initial limit exists
Twice-weekly upkeep schedule reduces this risk by avoiding abrupt stops
If you've used Enstilar continuously, taper rather than stop suddenly
Seek urgent medical advice if pustular spots develop after stopping treatment
The hypercalcaemia warning
Calcium-related concern:
Calcipotriol is a vitamin D analogue
Excessive use can raise calcium levels in the blood (hypercalcaemia)
Symptoms include thirst, frequent urination, nausea, vomiting, confusion, muscle weakness
Risk is low at the maximum recommended dose (15g daily)
Patients with calcium balance problems shouldn't use Enstilar
When to see a GP urgently
Some symptoms need prompt review:
Worsening of psoriasis despite treatment
Pustular spots developing during or after treatment
Signs of skin infection (warmth, swelling, pus, fever)
Severe skin thinning at treated areas
Signs of allergic reaction (severe itching, rash, swelling)
Symptoms of Cushing's syndrome (facial swelling, weight gain, easy bruising)
Symptoms of hypercalcaemia (thirst, frequent urination, confusion)
Visual changes
Pregnancy and breastfeeding
Talk to your GP or our prescriber first:
Pregnancy: only use under specific medical advice
Animal studies haven't shown clear teratogenic effects, although human data is limited
Breastfeeding: only use under specific medical advice
Don't apply to breast area while breastfeeding
Simpler emollients and avoidance of triggers are sometimes preferred
If psoriasis flares severely during pregnancy, specialist input may be needed
Use in older adults
Older adults can use Enstilar with the usual considerations:
Skin tends to be thinner with age — extra care to avoid over-application
More likely to have other medicines that may interact
Aerosol can may be more difficult to grip for those with arthritis
Same age range applies — 18+ for licensed use in the UK
Driving and machinery
Enstilar has no effect on driving or operating machinery.
Side effects
Enstilar is generally well-tolerated when used as directed. So most users only experience mild local side effects. However, longer or more extensive use raises the risk of steroid-related effects.
Common side effects
Itching (pruritus) at the application site
Skin exfoliation (peeling)
Mild burning or stinging when first applied
Skin irritation
Dry skin
Less common side effects
Skin infection at the application site
Folliculitis (inflammation of hair follicles)
Eye irritation (especially with accidental eye contact)
Flare of psoriasis
Dermatitis at the application site
Erythema (redness)
Skin rash (including red and pustular)
Acne at the application site
Application site pain
Rare side effects
Hypersensitivity reactions
Skin striae (stretch marks)
Skin atrophy (thinning)
Rebound effect after stopping treatment
Very rare or theoretical side effects
Blurred vision
Cushing's syndrome (with excessive use)
Suppression of natural cortisol production (with prolonged extensive use)
Hypercalcaemia (with excessive use)
Pustular psoriasis (especially after abrupt discontinuation)
Worsening of glaucoma or cataracts (with prolonged use near the eyes)
Stop and seek urgent medical help if
You develop signs of severe allergic reaction
Severe skin reaction develops at the application site
Pustular psoriasis spots develop
Signs of skin infection appear
Visual changes develop
Significant skin thinning develops
Symptoms of systemic steroid absorption develop
Yellow Card reporting
If you notice any side effects, please report them through the MHRA Yellow Card scheme at https://yellowcard.mhra.gov.uk/, or talk to our pharmacist.
Drug interactions
Enstilar is applied topically, so systemic drug interactions are uncommon when used as directed.
Important interactions to know about
Tell our prescriber if you use:
Other topical corticosteroids — additive effects
Calcium supplements (high doses) — theoretical risk of raising calcium levels further
Vitamin D supplements (high doses) — theoretical risk of raising calcium levels
Thiazide diuretics — can raise calcium levels
Other psoriasis treatments (light therapy, coal tar) — discuss timing with prescriber
Whole-body psoriasis medicines (methotrexate, ciclosporin, biologics) — may need coordinated care
Don't combine with
Specifically avoid combining Enstilar with:
Other strong topical steroids on the same area
Other calcipotriol products on the same area
Salicylic acid preparations — can reduce calcipotriol effectiveness
Occlusive dressings unless specifically directed
Generally fine alongside
Less concerning combinations:
Emollients and moisturisers (use at different times)
Most oral medications (very low systemic absorption from skin)
Most other prescription medications
Vitamin and mineral supplements at normal doses
Hormonal contraception
Routine vaccinations
Frequently asked questions
How is Enstilar different from Dovobet ointment?
Same actives, different format:
Same active ingredients (calcipotriol 50mcg/g + betamethasone 0.5mg/g)
Same maker (LEO Pharma)
Enstilar is a clean aerosol foam; Dovobet ointment is greasy
Enstilar penetrates skin better due to supersaturation
Enstilar is approved for twice-weekly upkeep; Dovobet ointment is not
Dovobet ointment moisturises very dry plaques better
Choice often comes down to skin type, lifestyle, and personal preference
How is Enstilar different from Dovobet gel?
Newer foam vs older gel:
Same active ingredients in both
Enstilar showed superior efficacy vs Dovobet gel in PSO-ABLE clinical trial
Enstilar is approved for twice-weekly upkeep; Dovobet gel is not
Both work for scalp psoriasis
Enstilar is generally cleaner to apply
What does "supersaturated" mean?
It's the clever bit of foam science:
Drug solutions normally have a stable maximum concentration
Enstilar holds the actives at concentrations higher than normally stable
After spraying, the solvents evaporate quickly
This leaves a layer of active at very high concentration on the skin
More active is available at the skin surface to penetrate inwards
So this makes the foam more effective per gram than ointment or gel
How quickly does Enstilar work?
Different effects show at different speeds:
Itch and redness reduction: usually within the first few days
Scale reduction: noticeable from week 2-3
Full benefit: typically by week 4
If no improvement after 2-4 weeks, talk to our prescriber
Can I keep using Enstilar after the 4 weeks?
Yes — this is Enstilar's unique advantage:
Enstilar is approved for twice-weekly upkeep after a successful 4-week course
Apply twice weekly to areas previously affected
Based on the PSO-LONG trial — 52 weeks of safe use
Helps keep psoriasis in remission rather than waiting for flares
Regular medical review every 4-6 months
Is Enstilar safe long-term?
Yes, with appropriate use:
PSO-LONG trial showed 52 weeks of twice-weekly use was generally safe
Skin thinning rates were low
Calcium balance remained normal
Regular medical review supports long-term safe use
Don't exceed maximum daily dose or area limits
Stop and review if any concerning symptoms develop
Can children use Enstilar?
In the UK, no:
Enstilar isn't licensed for under-18s in the UK
Some other markets (US) have approved use from 12+
Children with psoriasis need specialist input
Different treatments may be more suitable for children
Can I use Enstilar on my scalp?
Yes — the foam format suits scalp use particularly well:
Foam penetrates through hair more easily than ointment
Less greasy residue means easier to use during the day
Spray onto scalp from a few cm distance
Rub in gently with fingers
Allow to absorb before styling hair
Can I use Enstilar on my face?
Generally no — be careful:
Don't spray directly on the face
Facial skin is thinner and more sensitive
Higher risk of side effects (skin thinning, rosacea-like changes)
Don't use on the face unless specifically directed by your prescriber
Different treatments are usually better for facial psoriasis
Is Enstilar flammable?
Yes — it's a pressurised aerosol with flammable propellants:
Don't use near naked flames or lit cigarettes
Don't smoke during or immediately after application
Don't puncture or burn the can, even when empty
Don't store at temperatures above 50°C
Don't leave in hot cars
Allow foam to dry before getting dressed in synthetic clothes
What if I can't grip the can well?
Practical considerations:
Arthritic hands or grip problems may make the can hard to use
Holding the can at the bottom with both hands can help
Ask a household member or carer to assist if needed
Talk to our pharmacist about alternative formats if the foam isn't practical
Can I use Enstilar during pregnancy?
Talk to your GP or our prescriber first:
Only use under specific medical advice during pregnancy
Simpler emollients are usually preferred during pregnancy
Can I use Enstilar while breastfeeding?
Talk to your GP first:
Use only under specific medical advice
Don't apply to breast area while breastfeeding
Small amounts only to specific areas
Simpler emollients are usually preferred while breastfeeding
Can I use Enstilar with moisturisers?
Yes — and often you should:
Emollients and moisturisers are first-line skin care for psoriasis
Use at different times from Enstilar
Allow Enstilar to absorb before applying moisturiser
Or apply moisturiser first, wait an hour, then apply Enstilar
Heavy emollient use after bathing helps everyone with psoriasis
How long does a 60g can last?
Depends on how much you need:
A 60g can typically lasts several weeks for most patients
On twice-weekly upkeep, a can can last months
Use sparingly — small amounts spread well
Don't waste foam by overspraying
What if I miss the 4-week medical review?
Don't worry, but reschedule:
Medical review is important to assess response and plan next steps
Continue daily use until your review
Contact our prescriber to arrange review as soon as possible
Don't continue daily use indefinitely without review
Don't start twice-weekly upkeep without prescriber agreement
How should I store Enstilar?
Storage:
Don't store above 30°C
Don't freeze
Don't expose to temperatures above 50°C
Don't store in direct sunlight or hot cars
Don't puncture or burn the can
Keep out of sight and reach of children
Don't use after the expiry date
How do I order from Courier Pharmacy?
Add Enstilar to your basket on courierpharmacy.co.uk and complete the online consultation. Our prescriber will review and confirm whether Enstilar is suitable for your situation. Your order goes out in plain, discreet packaging.
More than a prescription: our community
Healthcare shouldn't only happen when you're paying for it.
Every fortnight we run free drop-in talks and clinics at Insomnia, Derby, from 10am to 12pm. So we show up, even when it's free.
Bring a question, bring a friend, bring a stack of bewildering letters from another clinic. We'll sit with you.
We cover psoriasis, eczema, acne, hair loss, MCAS, menopause, men's and women's health, digestive health, ADHD, autism support, allergies, asthma, weight management, and whatever else people bring through the door. No appointment. No cost. No pressure. Just real support and treatment that fits.
This article is for information only and isn't a substitute for personal medical advice. Always speak to a qualified prescriber before starting or changing treatment. Worsening psoriasis, pustular spots developing during or after treatment, signs of skin infection, or any unexpected symptoms need prompt medical assessment. Enstilar is a pressurised aerosol containing flammable propellants — keep away from sources of ignition.
How this content was created
Written by the Courier Pharmacy editorial team and reviewed by a GPhC-registered pharmacist.
The content is grounded in the latest LEO Pharma Summary of Product Characteristics for Enstilar Cutaneous Foam, the PSO-FAST and PSO-LONG clinical trial publications, the PSO-ABLE comparison study, NICE Clinical Knowledge Summary on psoriasis, British Association of Dermatologists guidance, NHS guidance, and the real experience of patients managing long-term plaque psoriasis. In addition, it draws on the real questions patients bring to our drop-in clinics in Derby.
