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Adapalene (0.1%) Benzoyl Peroxide (2.5%) Gel

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  • Adapalene and Benzoyl Peroxide Gel is a once-daily prescription topical for mild to moderate acne
  • It combines adapalene 0.1% (a third-generation retinoid) with benzoyl peroxide 2.5% (antimicrobial and keratolytic)
  • Non-antibiotic, so no 12-week ceiling
  • Prescription only, dispensed by Courier Pharmacy following UK prescriber review
  • Pack size of 45g

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Adapalene (0.1%) Benzoyl Peroxide (2.5%) Gel
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Description

Product description Adapalene and Benzoyl Peroxide Gel

What Adapalene and Benzoyl Peroxide Gel is

Adapalene and Benzoyl Peroxide Gel is a topical prescription treatment for acne. Firstly, each gram contains adapalene 0.1% (1 mg) and benzoyl peroxide 2.5% (25 mg). Additionally, adapalene is a third-generation retinoid. Meanwhile, benzoyl peroxide is an antimicrobial and keratolytic agent. As a result, the combination targets the main biological drivers of acne through two different mechanisms. It is a generic equivalent of the branded product Epiduo (originally manufactured by Galderma), and multiple UK generic manufacturers produce it under licence. The Epiduo Summary of Product Characteristics remains the reference document for the actives, indications, and safety profile.

Why the generic option matters

Generic medicines contain the same active ingredients at the same strengths as the branded originals. In particular, they must meet the same UK regulatory standards for quality, safety, and efficacy. Additionally, they typically cost significantly less than branded versions. Meanwhile, the clinical effect is the same. As a result, choosing the generic version is a sensible way to reduce the cost of treatment without losing any of the benefit.

Why the standard strength suits most patients

Adapalene and Benzoyl Peroxide Gel contains adapalene at 0.1%, the standard prescription strength. In particular, this is the concentration used first-line for most patients starting a topical retinoid combination. Meanwhile, the benzoyl peroxide component sits at 2.5%. Additionally, a stronger version (Epiduo Forte) exists at three times the adapalene concentration for cases where the standard strength doesn’t give enough response. As a result, Adapalene and Benzoyl Peroxide Gel is often the starting point in the topical acne pathway before considering a step up.

A non-antibiotic combination

Unlike combinations that contain a topical antibiotic (such as clindamycin), Adapalene and Benzoyl Peroxide Gel contains no antibiotic. Firstly, this means no risk of driving antibiotic resistance. Additionally, there’s no 12-week ceiling on how long you can use it. Meanwhile, it can be used long-term for maintenance under prescriber guidance. Furthermore, NICE NG198 acne guidance supports adapalene plus benzoyl peroxide as a first-line combination precisely because it avoids the antibiotic resistance issue.

Key features and specifications

  • Active ingredients: adapalene 1 mg/g (0.1%) and benzoyl peroxide 25 mg/g (2.5%)
  • Form: white to very pale yellow opaque topical gel
  • Pack sizes: commonly 30g, 45g, or 60g tubes
  • Class: fixed-combination topical retinoid and antimicrobial for acne
  • Legal status: Prescription Only Medicine (POM)
  • Excipients: propylene glycol, glycerol, poloxamer, docusate sodium, disodium edetate, methylhydroxypropylcellulose, sodium hydroxide, purified water
  • Storage: below 25 degrees Celsius, no refrigeration required
  • Suggested image alt text: Adapalene 0.1% and Benzoyl Peroxide 2.5% Gel tube generic Epiduo topical acne

Additional information

Quantity

1 x 45g, 2 x 45g, 3 x 45g

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

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Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


Checked By
Majad Mahroof
Bsc Pharm(hons), Senior Clinical Pharmacist Primary Care, Clinically Enhanced Pharmacist Independent Prescriber.

Bsc Pharm(hons), Senior Clinical Pharmacist Primary Care, Clinically Enhanced Pharmacist Independent Prescriber.


Adapalene (0.1%) Benzoyl Peroxide (2.5%) Gel

The generic first-line combination for mild to moderate acne

If your acne needs more than benzoyl peroxide alone can deliver but you’d rather not pay brand prices, the generic Adapalene and Benzoyl Peroxide Gel gives you exactly the same clinical treatment as branded Epiduo. Firstly, it combines a third-generation retinoid (adapalene 0.1%) with benzoyl peroxide 2.5%. Additionally, it tackles acne through two different, complementary mechanisms. Meanwhile, unlike antibiotic combinations, there’s no 12-week ceiling on how long you can use it. At Courier Pharmacy, we help you decide whether it fits your acne pattern and skin type.

What is Adapalene and Benzoyl Peroxide Gel: overview

  • A once-daily prescription gel for mild to moderate acne vulgaris.
  • Combines two well-established acne actives: adapalene (retinoid) and benzoyl peroxide (antimicrobial and keratolytic).
  • Licensed for adults and adolescents from 9 years.
  • A first-line combination in NICE acne guidance, without the antibiotic resistance concerns of clindamycin-containing gels.
  • No 12-week ceiling, so suitable for extended treatment under prescriber guidance.

Why the adapalene strength matters

Adapalene is a third-generation retinoid. Firstly, it binds selectively to retinoic acid receptors in skin cells. Meanwhile, it normalises the abnormal cell turnover that leads to blocked pores. Additionally, at 0.1%, this is the standard prescription strength for topical retinoid combinations. As a result, comedolytic and anti-inflammatory action is well-established at this concentration, which suits most patients starting a retinoid combination.

Generic version vs branded Epiduo Forte

Meanwhile, both this generic product and Epiduo Forte contain 2.5% benzoyl peroxide. Additionally, the difference is entirely in the adapalene component. In particular, this generic gel and standard Epiduo have adapalene 0.1%, while Epiduo Forte has adapalene 0.3%. Furthermore, the standard 0.1% strength suits most patients starting a retinoid combination or those with milder acne. As a result, your prescriber picks based on your acne severity and skin tolerance.

Where it fits in the NICE acne pathway

NICE NG198 (published in 2021) recommends fixed-combination topicals as first-line treatment for mild to moderate acne. In particular, adapalene plus benzoyl peroxide is one of the recommended options. Meanwhile, the standard strength (0.1% adapalene) available in this generic product and in branded Epiduo is often the first version tried. Additionally, if response is inadequate, Epiduo Forte at 0.3% adapalene may be the next step. As a result, the choice depends on your acne subtype, skin sensitivity, and previous treatment history.

How it compares to Duac

Duac (clindamycin plus benzoyl peroxide) is an antibiotic-containing combination. In contrast, Adapalene and Benzoyl Peroxide Gel uses a retinoid (adapalene) instead of an antibiotic. Firstly, this means no antibiotic resistance concern with adapalene combinations. Additionally, no 12-week ceiling applies. However, Duac may be more suitable for patients who can’t tolerate retinoids. As a result, the two products serve overlapping but distinct patient groups.

Why choose Courier Pharmacy for your Adapalene and Benzoyl Peroxide Gel

Registered, independent, and patient-led

Courier Pharmacy is a UK-registered independent pharmacy. The General Pharmaceutical Council regulates us. Firstly, acne looks different for every patient. Additionally, your acne pattern, skin sensitivity, and previous treatments all matter. As a result, our prescribers ask about those things. Getting your acne treatment right is about the fit.

Dr Ada Jex-Cori, our brand pharmacist

Our brand pharmacist is Dr Ada Jex-Cori. She represents the spirit of what we do. Named for Ada Lovelace, Sophia Jex-Blake, and Gerty Cori, she stands for evidence-led, unafraid-of-questions medicine. Her message is straightforward. You’re not broken. The system is. We’re here to change that.

Dr Ada Jex Cori with coupon code AJC10 courierpharmacy.co.uk

Care that keeps showing up

We don’t disappear after we’ve dispensed. Furthermore, if your skin flares during the retinisation phase, we’re here. Additionally, if you’re building up frequency or planning long-term use, we help you think that through. For patients navigating hormonal acne, PCOS, or other complicating factors, that continuity matters. Care that fits you means care that keeps showing up.

Free fortnightly drop-in clinics in Derby

Healthcare shouldn’t only happen when you’re paying for it. Every fortnight, we run free drop-in talks at Insomnia, Derby, from 12 to 1pm. Anyone can come. No appointment. No cost. No pressure. We cover skincare, acne, hair loss, hormones, and more.

Buy Adapalene and Benzoyl Peroxide Gel (Prescription Only) from Courier Pharmacy

Adapalene and Benzoyl Peroxide Gel is a Prescription Only Medicine. You can request it at courierpharmacy.co.uk. Firstly, complete an online consultation. Then, a UK-qualified prescriber reviews your answers. If approved, we dispense and deliver discreetly.

  1. Complete a quick online consultation
  2. A UK prescriber reviews your answers
  3. If approved, a prescription is issued
  4. We dispense and deliver discreetly to your door

If it isn’t suitable for you, we’ll explain why and suggest the next best option.

Customer journey at courierpharmacy.co.uk

Summary

  • Contains adapalene 0.1% and benzoyl peroxide 2.5% in a once-daily gel.
  • The generic equivalent of standard Epiduo, delivering identical clinical treatment at generic pricing.
  • Licensed for acne vulgaris in adults and children from 9 years, typically mild to moderate forms.
  • A non-antibiotic combination, so there’s no 12-week ceiling and it can be used long-term under prescriber guidance.
  • Adapalene and Benzoyl Peroxide Gel is a Prescription Only Medicine. A UK-qualified prescriber reviews every request at courierpharmacy.co.uk.

Active ingredients in Adapalene and Benzoyl Peroxide Gel

Adapalene 0.1%

Adapalene is a third-generation topical retinoid. In particular, it binds selectively to certain retinoic acid receptors in skin cells. Meanwhile, this triggers changes that normalise cell turnover in the pilosebaceous unit. Additionally, adapalene has direct anti-inflammatory properties too. As a result, it addresses both the blocked pore and the inflammatory sides of acne. At 0.1%, this is the standard prescription strength used first-line.

Benzoyl peroxide 2.5%

Benzoyl peroxide is a potent oxidising agent. Firstly, it releases oxygen radicals that kill Cutibacterium acnes, the main bacterial contributor to acne. Additionally, it has a mild keratolytic action, helping to unblock pores. Meanwhile, at 2.5%, this is the standard concentration used in fixed-combination acne treatments. As a result, this strength balances antibacterial effect against skin tolerability.

Gel base

The gel base includes propylene glycol, glycerol, and poloxamer. Meanwhile, this delivers the actives in a light, quick-drying formulation. Additionally, no refrigeration is needed, unlike the Duac range which requires cool storage before opening. As a result, storage is more convenient and the gel is stable at room temperature under normal conditions.

Dr Ada Jex Cori measuring APIs courierpharmacy.co.uk

What is Adapalene and Benzoyl Peroxide Gel for?

Mild to moderate acne

Adapalene and Benzoyl Peroxide Gel is licensed for the treatment of acne vulgaris when comedones, papules, and pustules are present. In particular, it's most often used for mild to moderate acne as a first-line topical combination. Meanwhile, more severe or more resistant acne may need Epiduo Forte (adapalene 0.3%, branded only) or other approaches. As a result, your prescriber picks the strength that matches your acne severity and skin tolerance.

Where it fits versus other acne treatments

Meanwhile, several first-line topicals exist for acne. Firstly, benzoyl peroxide alone suits milder inflammatory acne. Additionally, adapalene plus benzoyl peroxide (available as this generic gel or branded Epiduo) is often the first combination tried because it delivers the retinoid benefit alongside benzoyl peroxide. Furthermore, clindamycin plus benzoyl peroxide (Duac) is another combination option but has the 12-week antibiotic limit. Meanwhile, if the standard 0.1% strength doesn't give enough response, Epiduo Forte at higher adapalene strength is the next step. As a result, standard-strength adapalene plus benzoyl peroxide often sits at the entry point of prescription combination therapy.

What it won't fix

Above all, this gel is for moderate to severe acne vulgaris, not nodulocystic acne or severe scarring acne. In particular, deep cystic acne usually needs oral isotretinoin. Additionally, hormonal acne patterns may need combined oral hormonal treatment (such as combined contraceptive pills or spironolactone). Meanwhile, if your acne is not responding, discuss the wider picture with your prescriber.

Dr Ada Jex Cori spots courierpharmacy.co.uk

How does Adapalene and Benzoyl Peroxide Gel work?

Adapalene normalises follicle cell turnover

Adapalene binds to specific retinoic acid receptors in skin cells. Firstly, this normalises the abnormal cell turnover that leads to blocked follicles. Additionally, it reduces the formation of microcomedones (the earliest stage of a spot). Meanwhile, it also has direct anti-inflammatory effects on the surrounding tissue. As a result, both existing acne clears faster and new spots form less often.

Benzoyl peroxide's dual action

Benzoyl peroxide penetrates the skin and pilosebaceous unit. Firstly, it releases oxygen radicals that kill Cutibacterium acnes directly. Additionally, it has a keratolytic action, helping unblock pores. Meanwhile, unlike antibiotics, bacteria cannot develop resistance to oxidative damage. As a result, benzoyl peroxide keeps working reliably even with long-term use.

Why the combination reduces irritation

Adapalene and benzoyl peroxide have complementary mechanisms. In particular, using both together often gives better results than either alone at higher strengths. Meanwhile, the fixed combination allows lower concentrations of each ingredient to work synergistically. Additionally, this can mean less overall irritation than stronger single-ingredient products at the same acne target.

How long until you see results

Some improvement usually appears within 4 to 8 weeks. However, maximum benefit typically shows within 12 weeks. Meanwhile, response varies from person to person. Additionally, unlike antibiotic combinations, treatment can continue long-term for maintenance. As a result, consistency over months and years often keeps acne under control.

Dr Ada Jex Cori reading courierpharmacy.co.uk

How to apply Adapalene and Benzoyl Peroxide Gel

Step-by-step technique

Firstly, gently wash the affected areas with a mild non-medicated cleanser. Rinse with warm water and pat completely dry. Then, wait about 20 to 30 minutes if you can, to reduce initial stinging. Next, squeeze a small amount of gel (pea-sized for face) onto your fingertip. After that, apply a thin layer to all areas affected by acne, not just individual spots. Finally, wash your hands thoroughly.

Skincare routine alongside

Meanwhile, use a gentle non-comedogenic moisturiser to manage dryness and peeling. Additionally, use a broad-spectrum SPF 30 or higher during the day. Furthermore, avoid harsh cleansers, alcohol-based toners, and physical exfoliants during treatment. As a result, keep your routine minimal so the gel can work without added irritation.

Bleaching precautions

Above all, benzoyl peroxide bleaches hair, coloured fabrics, and dyed materials. In particular, apply carefully to avoid contact with your hair and eyebrows. Additionally, use white or old pillowcases and towels during the treatment period. Meanwhile, wait until the gel has fully dried before putting on clothes. Furthermore, wash your hands immediately after applying.

Treatment dosage Adapalene and Benzoyl Peroxide Gel

Adult and adolescent dose

For adults and children aged 9 and over, apply a thin layer once daily in the evening. In particular, apply to the entire affected area of the face and trunk, not just individual spots. Additionally, the skin should be gently washed and patted dry first. Meanwhile, use fingertips to spread the gel evenly.

Building up frequency (retinisation)

Even though the licensed instruction is once daily from the start, many patients tolerate the retinoid better by building up. Firstly, apply every third night for the first 1 to 2 weeks. Additionally, then every other night for the next 1 to 2 weeks. Meanwhile, most patients can move to nightly use after 3 to 4 weeks. However, listen to your skin. If irritation persists, drop back to a lower frequency until it settles.

How long you can use it

Unlike antibiotic-containing combinations, Adapalene and Benzoyl Peroxide Gel has no built-in 12-week ceiling. In particular, this is because there's no antibiotic to drive resistance. Meanwhile, you can use it as long as your prescriber advises, including long-term maintenance. Additionally, most patients see maximum benefit within 4 to 8 weeks and can continue at a maintenance frequency after that. As a result, review with your prescriber periodically to confirm continued treatment is right for you.

Dr Ada Jex Cori appyling a cream courierpharmacy.co.uk

Warnings and precautions for Adapalene and Benzoyl Peroxide Gel

Bleaching effect on hair and fabrics

Firstly, benzoyl peroxide bleaches hair and coloured or dyed fabrics permanently. In particular, this includes coloured towels, pillowcases, clothing, and carpets. Meanwhile, use white bedding and towels during treatment. Additionally, take care with eyebrow hair when applying to the forehead. As a result, plan around this before starting treatment.

Sun sensitivity

Both adapalene and benzoyl peroxide increase skin sensitivity to sunlight. Firstly, avoid sunbeds and prolonged sun exposure during treatment. Additionally, use SPF 30 or higher daily. Meanwhile, wear protective clothing and a hat when outdoors for extended periods. As a result, sun protection is a non-negotiable part of treatment. Furthermore, if you develop sunburn, pause the gel until skin has fully recovered.

Skin irritation (retinisation)

Most patients experience some redness, dryness, or peeling in the first few weeks. Additionally, this retinisation phase usually settles as your skin adapts over 4 to 12 weeks. However, if irritation is significant, reduce application frequency to every other night or every third night until skin recovers. Meanwhile, an oil-free non-comedogenic moisturiser helps. Above all, if severe irritation persists, stop and contact your prescriber.

Pregnancy and breastfeeding

Adapalene and Benzoyl Peroxide Gel should not be used during pregnancy. In particular, retinoids are known teratogens, and although topical adapalene has low systemic absorption, the theoretical risk means it's avoided. Additionally, use effective contraception if there's any pregnancy risk. Meanwhile, it should not be applied to the breast area during breastfeeding. Furthermore, discuss any pregnancy or breastfeeding during your consultation.

Not for use on inflammatory or damaged skin

Meanwhile, do not apply Adapalene and Benzoyl Peroxide Gel to skin affected by eczema, seborrhoeic dermatitis, or sunburn. Additionally, avoid application on broken skin, cuts, or areas with existing inflammation. Furthermore, wait until any acute skin problem has fully settled before starting or resuming treatment. As a result, treatment starts from a healthy baseline.

Long-term use considerations

Unlike antibiotic combinations, there's no built-in ceiling on how long Adapalene and Benzoyl Peroxide Gel can be used. Meanwhile, review with your prescriber periodically (usually every 6 to 12 months) is sensible. Additionally, some patients continue for years at either full or reduced frequency for maintenance. As a result, ongoing review ensures continued treatment stays appropriate.

Dr Ada Jex Cori drug warning courierpharmacy.co.uk

Side effects of Adapalene and Benzoyl Peroxide Gel

Common side effects

The most common side effects affect up to 1 in 10 people. These include dry skin, irritant contact dermatitis, burning sensation, and skin irritation. Meanwhile, some patients notice redness or a brief stinging on application. Additionally, mild worsening of acne can occur in the first few weeks (a purging effect). As a result, most patients tolerate the gel with sensible skincare adjustments and slower build-up.

Uncommon side effects

Uncommon side effects (up to 1 in 100) include increased sensitivity to sunlight, sunburn, pruritus, dermatitis, and eczema. Furthermore, some patients develop skin discomfort or a rash. Additionally, allergic contact dermatitis is possible. Your prescriber may adjust or stop treatment if any of these persist.

Rare side effects

Rare side effects include eyelid oedema, throat tightness (angioedema), and marked skin discolouration. Meanwhile, more serious allergic reactions can occur but are uncommon. Above all, seek advice if the skin becomes significantly worse after starting treatment.

When to seek urgent help

Seek urgent help for signs of a severe allergic reaction (facial swelling, difficulty breathing, widespread rash). Similarly, seek help for severe or persistent skin irritation that doesn't settle with a lower application frequency. Meanwhile, any new worsening of your general health during treatment warrants review.

Yellow Card reporting

You can report any suspected side effects directly via the MHRA Yellow Card Scheme at https://yellowcard.mhra.gov.uk. Reporting side effects helps provide more information on the safety of this medicine.

Dr Ada Jex Cori side effects courierpharmacy.co.uk

Drug interactions with Adapalene and Benzoyl Peroxide Gel

Other topical retinoids

Firstly, avoid using Adapalene and Benzoyl Peroxide Gel alongside other topical retinoids (tretinoin, isotretinoin, tazarotene, or another adapalene product). In particular, combined retinoid use increases irritation without adding benefit. Additionally, if you're currently on another retinoid, discuss switching rather than layering. Meanwhile, oral isotretinoin is a separate consideration and needs specialist input.

Medicated soaps and astringents

Meanwhile, avoid using medicated soaps, astringents, or alcohol-heavy cleansers alongside Adapalene and Benzoyl Peroxide Gel. In particular, these can compound skin dryness and irritation. Additionally, physical scrubs and abrasive brushes should also be avoided during treatment. As a result, a simple gentle cleansing routine works best.

Sulfonamide-containing products

Additionally, benzoyl peroxide combined with topical sulfonamide-containing products can cause temporary yellow or orange discolouration of skin and facial hair. In particular, this is a cosmetic effect rather than a safety concern but can be startling. As a result, avoid combining unless your prescriber specifically advises it.

Dr Ada Jex Cori drug interactions courierpharmacy.co.uk

Frequently asked questions about Adapalene and Benzoyl Peroxide Gel

How quickly does Adapalene and Benzoyl Peroxide Gel work?

Some improvement can appear within 4 to 8 weeks. However, maximum benefit usually shows within 12 weeks. Meanwhile, consistency matters more than the specific week you notice change. Additionally, unlike antibiotic combinations, treatment can continue long-term.

What's the difference between this generic and Epiduo Forte?

Both products contain the same 2.5% benzoyl peroxide. However, they differ in the adapalene strength. Firstly, this generic gel (and standard branded Epiduo) has adapalene 0.1%. Additionally, Epiduo Forte has adapalene 0.3%, three times the strength. As a result, the standard 0.1% strength suits most patients starting treatment or those with mild to moderate acne, while Epiduo Forte suits more resistant or more severe cases.

How does this compare to Duac?

Both are topical acne combinations. However, they differ in composition. Firstly, Duac contains an antibiotic (clindamycin) plus benzoyl peroxide. Additionally, Adapalene and Benzoyl Peroxide Gel contains a retinoid (adapalene) plus benzoyl peroxide. Meanwhile, Duac has a 12-week ceiling due to antibiotic resistance concerns. However, this adapalene combination has no such ceiling and can be used long-term.

Can I use it long-term?

Yes. Unlike antibiotic combinations, there's no built-in ceiling on how long Adapalene and Benzoyl Peroxide Gel can be used. Meanwhile, many patients continue for months or years, sometimes at reduced frequency for maintenance. Additionally, periodic review with your prescriber ensures continued treatment stays appropriate.

Will it bleach my hair or clothes?

Yes. Benzoyl peroxide bleaches hair, coloured fabrics, and dyed materials. In particular, this includes towels, pillowcases, clothing, and even carpets. Meanwhile, use white bedding and towels during treatment. Additionally, take care around your eyebrows and hairline when applying.

Do I need SPF while using it?

Yes. Both adapalene and benzoyl peroxide increase sun sensitivity. Firstly, use SPF 30 or higher daily. Additionally, avoid sunbeds and prolonged sun exposure. Meanwhile, wear protective clothing and hats if you can't avoid strong sun. As a result, daily sunscreen is essential during treatment.

Can I use moisturiser with it?

Yes. In fact, a gentle non-comedogenic moisturiser often helps manage the dryness and peeling that occur early in treatment. Meanwhile, apply moisturiser after the gel has absorbed. Additionally, choose oil-free formulations to avoid clogging pores. As a result, moisturiser supports rather than works against treatment.

Should I stop if my skin gets irritated?

Some redness, dryness, or peeling in the first few weeks is normal retinisation. Firstly, try using the gel less often (every other night, or every third night) until your skin adapts. Additionally, use an oil-free moisturiser. Meanwhile, if irritation is severe or worsening, stop and contact your prescriber. As a result, don't push through significant irritation.

Can I use it while pregnant?

No. Adapalene and Benzoyl Peroxide Gel should not be used during pregnancy. In particular, retinoids are known teratogens, and although topical adapalene has low systemic absorption, the theoretical risk means it's avoided. Additionally, use effective contraception during treatment if there's any pregnancy risk. Meanwhile, discuss any pregnancy planning during your consultation.

Can I use it while breastfeeding?

Cautiously. Meanwhile, do not apply the gel to the breast area during breastfeeding. Additionally, discuss with your prescriber before starting. As a result, some patients wait until breastfeeding ends before starting this treatment, or use gentler alternatives during breastfeeding.

Can children use it?

Yes, from age 9 upward. In particular, the standard adapalene 0.1% + benzoyl peroxide 2.5% combination is licensed for children 9 years and over, a lower age than Epiduo Forte (12+). Meanwhile, it is not recommended for children under 9. Additionally, adolescents need careful skincare guidance to manage the dryness and sun sensitivity that treatment can cause.

Do I need to refrigerate it?

No. Unlike Duac, adapalene plus benzoyl peroxide gel doesn't need refrigeration. Meanwhile, store below 25 degrees Celsius at room temperature. Additionally, keep it away from direct sunlight and hot places. As a result, storage is simpler than for benzoyl peroxide products that require cool storage.

Can I combine it with other topical retinoids?

No. Firstly, layering retinoids increases irritation without adding benefit. Additionally, adapalene is already the retinoid in this gel, so adding tretinoin, isotretinoin, or another retinoid on top is not recommended. Meanwhile, if you're switching from another retinoid, do so under prescriber guidance.

Will it help with acne scars?

This gel treats active acne rather than existing scars. However, adapalene has some evidence for improving post-inflammatory hyperpigmentation over time. Meanwhile, dedicated scar treatments may help fade existing scars. Additionally, by reducing new spots, it helps prevent further scarring. As a result, discuss any scarring concerns with your prescriber.

Can I wear makeup over the gel?

Yes, once the gel has fully dried. Firstly, allow 15 to 20 minutes after applying before adding makeup. Additionally, use non-comedogenic (oil-free) makeup products. Meanwhile, remember that benzoyl peroxide can bleach some makeup brushes and pillowcases if it hasn't fully dried.

What if I forget to apply?

Apply as soon as you remember, unless it's nearly time for the next evening. Meanwhile, don't apply twice to catch up. Additionally, consistency over months matters more than any single missed application. As a result, resume normal application without doubling up.

How should I store it?

Store below 25 degrees Celsius. Additionally, keep it in the original packaging to protect from light. Meanwhile, keep it out of the reach of children. Furthermore, don't use it past the expiry date on the tube.

Can it be used on the back or chest?

Yes. Although the face is the most common area, this gel can be applied to acne on the back, chest, or shoulders. Meanwhile, larger areas need more product per application. Additionally, take extra care with bleaching precautions for clothing and bedding when treating body areas.

What if it doesn't work?

If your acne hasn't responded after 12 weeks of consistent use, contact your prescriber. In particular, they may combine with oral treatment (such as an antibiotic like lymecycline or hormonal treatment) or consider referral for isotretinoin. Meanwhile, don't just stop without discussion, as sudden discontinuation can cause a flare.

Will I need a prescription from Courier Pharmacy?

Yes. Adapalene and Benzoyl Peroxide Gel is a Prescription Only Medicine. A UK-qualified prescriber must review your suitability. You can complete the consultation at courierpharmacy.co.uk.

Disclaimer

Disclaimer: This information is for education only and isn't a substitute for personal medical advice. Always follow your prescriber's instructions.

Dr Ada Jex Cori FAQs courierpharmacy.co.uk

References

  1. British National Formulary (2024) Adapalene with benzoyl peroxide. Available at: https://bnf.nice.org.uk/drugs/adapalene-with-benzoyl-peroxide/
  2. Electronic Medicines Compendium (2025) Epiduo 1 mg/g / 25 mg/g gel: Patient Information Leaflet. Available at: https://www.medicines.org.uk/emc/product/6923/pil
  3. Electronic Medicines Compendium (2025) Epiduo 1 mg/g / 25 mg/g gel: Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/6923/smpc
  4. National Institute for Health and Care Excellence (2021) Acne vulgaris: management. NICE guideline NG198. Available at: https://www.nice.org.uk/guidance/ng198
  5. NHS (2023) Acne. Available at: https://www.nhs.uk/conditions/acne/
  Courierpharmacy.co.uk divider Dr Ada Jex Cori

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.15922.pdf

Adapalene (0.1%) Benzoyl Peroxide (2.5%) Gel courierpharmacy.co.uk
Adapalene (0.1%) Benzoyl Peroxide (2.5%) Gel
from£28.99

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