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Azelaic acid 20% and Niacinamide 4% topical cream

from£39.99

  • UK pharmacy-compounded combination cream — azelaic acid 20% (licensed strength from Skinoren) plus niacinamide 4% (vitamin B3) in an emollient cream base
  • Dual-mechanism approach: azelaic acid inhibits tyrosinase, kills acne bacteria, and normalises keratinisation; niacinamide reduces melanosome transfer, regulates sebum, and supports skin barrier
  • Versatile use for mild-to-moderate acne, rosacea (particularly papulopustular), post-inflammatory hyperpigmentation, and melasma — often when concerns overlap in the same patient
  • Well-tolerated and safe in pregnancy and breastfeeding; daily SPF 30+ essential for pigmentation results; part of the Gro skincare range
  • Pack size 30g
  • Expiry date: 30 days

TREATS:

Hyperpigmentation

FORMAT:

Cream

Availability:

Out of stock

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Description

Product description: Azelaic Acid 20% + Niacinamide 4% Cream

Skin concerns often overlap. After all, someone with acne frequently has post-inflammatory hyperpigmentation. Someone with rosacea often has associated redness and background pigmentation. Someone with melasma may have coexisting sensitivity or general uneven tone.

So single-active products often address only part of the picture — leaving patients layering multiple products, dealing with compatibility issues, and struggling to maintain complex routines. Combining well-tolerated actives with complementary mechanisms can genuinely simplify skincare while broadening coverage.

This azelaic acid 20% + niacinamide 4% cream addresses multiple skin concern pathways in a single application. Specifically, azelaic acid brings tyrosinase inhibition, antimicrobial action, and keratinisation normalising. Niacinamide brings melanosome transfer inhibition, sebum regulation, and barrier support.

As a result, the combination covers acne, rosacea, and pigmentation through different but complementary mechanisms. However, honest framing matters: this is a versatile mid-strength combination, not the strongest option for any single concern. So it fits patients with mild-to-moderate multi-concern situations rather than those needing intensive single-concern treatment.

How the two actives complement each other

The combined mechanisms cover multiple pathways:

For acne

  • Azelaic acid: antimicrobial action against P. acnes bacteria
  • Azelaic acid: normalises keratinisation, reducing blocked pores
  • Azelaic acid: anti-inflammatory action reducing papules and pustules
  • Niacinamide: sebum regulation over time
  • Niacinamide: anti-inflammatory action
  • Niacinamide: barrier support reducing sensitivity that can trigger acne

For rosacea

  • Azelaic acid: reduces papules and pustules (papulopustular rosacea)
  • Azelaic acid: anti-inflammatory action reduces overall redness
  • Niacinamide: reduces background redness through anti-inflammatory action
  • Niacinamide: barrier support reduces reactivity
  • Both actives: well-tolerated by rosacea-prone skin

For hyperpigmentation

  • Azelaic acid: inhibits tyrosinase, reducing melanin production in hyperactive melanocytes
  • Niacinamide: reduces melanosome transfer to visible skin layers
  • Combined: covers both production and transfer steps of pigmentation
  • Both actives: well-tolerated across all skin tones

Where this cream fits in skincare treatment

The UK approach to combination skin concerns follows a stepped path:

  • Step 1: Basic skincare routine (gentle cleanser, moisturiser, SPF)
  • Step 2: Single-active OTC options (niacinamide alone, vitamin C, OTC azelaic acid at lower strengths)
  • Step 3: Licensed monotherapies — Skinoren 20% cream, Finacea 15% gel, tretinoin, OTC retinols
  • Step 4: Compounded combination approaches — this product and similar Gro range combinations
  • Step 5: Prescription topical retinoids at higher strengths
  • Step 6: Prescription combination formulas (Kligman’s for pigmentation, retinoid + antibiotic for acne)
  • Step 7: Oral prescription therapy (antibiotics, spironolactone, isotretinoin, tranexamic acid)
  • Step 8: Procedural treatments (peels, microneedling, laser)
  • Step 9: Advanced procedures for resistant cases

So this combination typically sits at Step 4 — the compounded combination layer. In short, it’s a next step after single-active approaches, or a sensible starting point for patients with multiple concerns wanting broader coverage from the start.

This cream vs licensed Skinoren 20% cream

Same azelaic acid strength, different overall formulation:

  • Skinoren 20% cream: licensed monotherapy by Bayer
  • In contrast, this cream combines azelaic acid 20% with niacinamide 4%
  • Both contain the same licensed strength of azelaic acid
  • This combination adds niacinamide’s complementary mechanisms
  • Skinoren is licensed specifically for acne
  • This combination broadens coverage to include niacinamide’s pigmentation and barrier benefits
  • Skinoren has full Marketing Authorisation
  • This combination is a compounded preparation
  • In general, Skinoren fits pure acne monotherapy; this combination fits multi-concern situations

This cream vs licensed Finacea 15% gel

Different strengths and formulations for different indications:

  • Finacea 15% gel: licensed for papulopustular rosacea
  • In contrast, this cream uses 20% azelaic acid with added niacinamide
  • Finacea is a gel formulation — can be drying for some patients
  • This is a cream base — generally better tolerated
  • Finacea is licensed specifically for rosacea
  • This combination covers rosacea plus acne and pigmentation
  • Finacea has Marketing Authorisation
  • This combination is compounded
  • In general, Finacea fits pure rosacea; this combination fits mixed concerns

This cream vs OTC azelaic acid products

Prescription-strength vs OTC alternatives:

  • OTC azelaic acid: typically 5-10% concentration
  • In contrast, this cream uses the licensed prescription-strength 20%
  • OTC options are widely available and often cheaper
  • However, higher strengths have stronger evidence base
  • OTC options don’t usually combine with niacinamide at this level
  • Also, this combination offers pharmacist-guided use
  • In general, OTC options are a starting point; this fits patients wanting prescription-strength combination

This cream vs niacinamide 3% cream alone (also in the Gro range)

Single active vs combination:

  • Niacinamide 3% cream: single active focused on foundation skincare
  • In contrast, this combination adds azelaic acid for stronger targeted action
  • Niacinamide alone fits foundation skincare and mild pigmentation
  • This combination fits more active concerns needing multiple mechanisms
  • Niacinamide alone is gentler for very sensitive skin
  • Azelaic acid can cause initial tingling for 1-2 weeks
  • In general, start with niacinamide 3% for foundation; step up to this combination for more targeted action

This cream vs tretinoin 0.025% (also in the Gro range)

Different mechanism and tolerability profiles:

  • Tretinoin: prescription-strength retinoid, causes retinization, contraindicated in pregnancy
  • In contrast, this combination uses well-tolerated actives, pregnancy-safe
  • Tretinoin delivers stronger anti-aging results
  • This combination delivers broader multi-concern coverage without retinization
  • Tretinoin causes photosensitivity
  • This combination doesn’t cause photosensitivity
  • Both can be used together (this combination morning, tretinoin evening)
  • In general, tretinoin fits intensive anti-aging; this fits mild-to-moderate multi-concern situations

This cream vs hydroquinone-containing formulas

Different pigmentation approaches:

  • Hydroquinone: potent tyrosinase inhibitor, limited to 3-6 month courses
  • In contrast, this combination uses safer long-term actives
  • Hydroquinone is more potent for stubborn or advanced pigmentation
  • However, hydroquinone can cause ochronosis long-term
  • Also, hydroquinone can’t be used in pregnancy
  • This combination is safer for long-term maintenance
  • Some patients use hydroquinone short-term then this combination for maintenance
  • In general, hydroquinone fits severe pigmentation; this fits mild-to-moderate and maintenance

This cream vs Kligman’s formula

Prescription combination vs pharmacy compounded combination:

  • Kligman’s formula combines hydroquinone 4% + tretinoin 0.05% + fluocinolone 0.01%
  • In contrast, this uses azelaic acid + niacinamide (much better tolerated)
  • Kligman’s is the most potent topical for melasma
  • Kligman’s requires prescriber supervision and limited-duration use
  • Higher side effect profile with Kligman’s
  • Contraindicated in pregnancy
  • This combination fits before or after Kligman’s as maintenance
  • Also fits patients who can’t or won’t use hydroquinone

This cream vs prescription topical antibiotics

Different clinical positioning for acne:

  • Topical clindamycin or erythromycin: prescription antibiotics
  • In contrast, this uses non-antibiotic mechanisms (azelaic acid antimicrobial + niacinamide)
  • Antibiotics work faster for inflammatory acne
  • However, antibiotics contribute to resistance concerns
  • Azelaic acid antimicrobial doesn’t contribute to standard antibiotic resistance
  • This combination adds pigmentation coverage antibiotics don’t offer
  • In general, antibiotics fit inflammatory acne; this combination fits acne with pigmentation

Who this cream may suit well

This product may suit:

  • Adults with mild-to-moderate acne plus post-inflammatory hyperpigmentation
  • Adults with papulopustular rosacea
  • Adults with mixed rosacea (redness plus bumps)
  • Adults with melasma wanting a well-tolerated approach
  • Adults with darker skin tones dealing with acne and pigmentation together
  • Pregnant or breastfeeding women with acne or pigmentation
  • Adults who couldn’t tolerate tretinoin
  • Adults wanting simpler skincare with broader mechanism coverage
  • Adults preparing for or maintaining after peels/laser
  • Adults committed to consistent use plus daily SPF

Who might suit other options better

Other options may suit better for:

  • Adults with severe cystic or nodular acne (oral treatment fits better)
  • Adults with severe melasma unresponsive to well-tolerated actives (Kligman’s or oral tranexamic acid)
  • Adults wanting intensive anti-aging results (tretinoin fits better)
  • Adults with severe rosacea flushing (may need oral treatment or laser)
  • Adults with known allergy to azelaic acid, niacinamide, or vitamin B3
  • Adults with severe eczema or dermatitis on treatment area
  • Adults with active herpes simplex on face
  • Adults wanting immediate results
  • Adults who won’t apply consistently
  • Adults who won’t use daily SPF (pigmentation results won’t be visible)
  • Adults happy with OTC options that meet their needs

Courier Pharmacy supply

This is a pharmacy-compounded skincare preparation from the Gro skincare range. So supply happens after our pharmacist reviews your skin concerns through a consultation. The consultation covers:

  • Your specific skin concerns (acne, rosacea, pigmentation, or combinations)
  • Location, pattern, and severity
  • Duration and any known triggers
  • Previous treatments tried (OTC actives, licensed products, prescription treatments)
  • Your skin tone and Fitzpatrick type
  • Current skincare routine and SPF habits
  • Any relevant medical history
  • Pregnancy or breastfeeding status if applicable
  • Discussion of realistic timeline for each concern
  • How this fits alongside any other Gro range or prescription treatments
  • Plan for review at 3 months to assess response

In short, this isn’t a checkbox consultation — it’s a skincare conversation covering your specific mix of concerns.

Key features and specs

  • Active ingredients: azelaic acid 20% (200mg/g) and niacinamide 4% (40mg/g)
  • Base: emollient cream base with barrier support
  • Form: light cream, absorbs cleanly
  • Typical pack size: tube designed to last approximately one to two months
  • Typical dose: small amount applied to affected areas once or twice daily
  • Application area: face, neck, chest, or affected body areas
  • Timing: morning or evening (or both) — no photosensitivity concerns
  • Essential companion: daily broad-spectrum SPF 30+ for pigmentation goals
  • Storage: room temperature, away from direct sunlight
  • Typical shelf life: 3-6 months after preparation
  • Legal status: pharmacy-compounded skincare preparation combining two well-established actives
  • Suitable in pregnancy and breastfeeding
  • Part of the Gro skincare range at Courier Pharmacy

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Overview

Active ingredients

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Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


Checked By
Safdar Ali
BSc Pharmacy

Pharmacist


Azelaic Acid 20% and Niacinamide 4% Topical Cream — Compounded Combination Skincare from the Gro Skincare Range

This is a UK pharmacy-compounded skincare preparation combining two evidence-based actives — azelaic acid 20% (the licensed strength found in Skinoren cream) and niacinamide 4% (a form of vitamin B3) — in an emollient cream base. So each tube delivers two complementary mechanisms in a single product: azelaic acid inhibits tyrosinase (reducing melanin production), reduces P. acnes bacteria, and normalises keratinisation, while niacinamide reduces melanosome transfer to surface skin cells, regulates sebum, and supports skin barrier function. As a result, this combination fits patients dealing with acne, rosacea, hyperpigmentation, or combinations of these concerns — offering a broader mechanism than either active alone. Important: this is a compounded skincare preparation. So the individual actives are used in licensed products (azelaic acid as Skinoren and Finacea), but this specific combination is prepared for individual patients under our pharmacy compounding process. Part of the Gro skincare range at Courier Pharmacy.

At Courier Pharmacy, we believe in treatment that fits the person — but only where it’s honest, safe, and consented to.

This page covers what azelaic acid 20% + niacinamide 4% cream is, how the two actives work together, who it might suit for acne, rosacea, or pigmentation, and how it compares to licensed monotherapies and other skincare options.

Regulatory position — please read first

Before going further, we want to be straight with you about three things:

First, this is a pharmacy-compounded skincare preparation combining two individually well-established actives. Azelaic acid at 20% is licensed as Skinoren cream (Bayer) for acne and Finacea 15% gel (Leo Pharma) for rosacea. Niacinamide is widely available in OTC skincare products at concentrations up to 10%. So the individual actives are well-known — but this specific combination is prepared as a compounded preparation for individual patients rather than a licensed combination product.

Second, the combination approach targets multiple mechanisms at once. Azelaic acid works on tyrosinase inhibition, antimicrobial action, and keratinisation. Niacinamide works on melanosome transfer, sebum regulation, and barrier support. As a result, one product covers multiple pathways — useful for patients dealing with combinations of acne, rosacea, and pigmentation.

Third, both actives are genuinely well-tolerated. Unlike hydroquinone (limited long-term use) or tretinoin (retinization phase, pregnancy contraindicated), both azelaic acid and niacinamide have clean long-term safety profiles and are considered safe in pregnancy and breastfeeding. So this combination fits situations where stronger prescription options aren’t wanted or aren’t suitable.

If any of these points raise concerns, please talk to our pharmacist before proceeding. After all, the honest picture is important — even for well-tolerated combination preparations.

Five key takeaways

  • This is a pharmacy-compounded combination skincare preparation from the Gro skincare range. So supply happens through pharmacist consultation covering your specific skin concerns (acne, rosacea, pigmentation, or combinations) and treatment goals
  • Two actives, complementary mechanisms: azelaic acid 20% inhibits tyrosinase (reducing melanin production) plus antimicrobial and keratinisation-normalising effects. Niacinamide 4% reduces melanosome transfer to surface skin cells, regulates sebum, and supports the skin barrier. As a result, one product covers acne, rosacea, and pigmentation pathways
  • Genuinely versatile — fits mild-to-moderate acne, rosacea (particularly papulopustular and erythematotelangiectatic types), post-inflammatory hyperpigmentation, melasma, or combinations of these concerns. Particularly useful when a single product across multiple concerns fits better than a routine of separate products
  • Well-tolerated safety profile — both actives are safe long-term, safe in pregnancy and breastfeeding, and don’t cause photosensitivity or retinization. Azelaic acid can cause initial tingling that typically settles within 2 weeks
  • Realistic timeline: early tolerability adjustment in weeks 1-2, acne improvements at 4-8 weeks, rosacea redness improvements at 8-12 weeks, pigmentation improvements at 12-24 weeks. Daily broad-spectrum SPF 30+ is essential for pigmentation results

Why choose Courier Pharmacy for the Gro skincare range

At Courier Pharmacy, our approach starts with a simple idea: treatment should fit the person, not force the person to fit the system.

Dr Ada Jex-Cori

Our service is shaped by the philosophy of Dr Ada Jex-Cori, our brand pharmacist.

Dr Ada represents the spirit of the pharmacy: evidence-led, community-rooted, and willing to challenge the one-size-fits-all approach to medicine. She is named in honour of three pioneering women in science: Ada Lovelace, the mathematician and visionary; Sophia Jex-Blake, the first female doctor in the UK who fought the medical establishment; and Gerty Cori, the biochemist and Nobel Prize winner.

In our fictional world of Etherwell, Dr Ada fights against pharma’s standardised approach to medicine. In the real world, she represents what we stand for. Her view is straightforward: you are not broken. The system is. And we are here to change that.

Dr Ada Jex Cori at courierpharmacy.co.uk holding a coupon

Skin concerns deserve serious attention

Skin concerns often overlap and get inadequately treated. Courier Pharmacy is different. So we recognise that:

  • Many patients have combinations of acne, rosacea, and pigmentation simultaneously
  • Single-active products often address only part of the picture
  • Layering multiple products creates compatibility and compliance issues
  • Skin concerns affect confidence, mental health, professional life
  • Depression and anxiety are significantly more common in visible skin concerns
  • Getting the right combination approach matters
  • The right treatment approach depends on the person, not a standard protocol

After all, skin concerns rarely present in isolation. So our pharmacist takes overlapping concerns seriously.

Honest framing about combination approaches

We’ll be straight about what combinations can and can’t do:

  • Combinations cover more mechanisms than single actives
  • However, combinations aren’t automatically stronger than well-chosen single actives
  • The strength of a combination is in mechanism coverage, not raw potency
  • For severe single-concern situations, focused prescription treatment often works better
  • For multi-concern situations, combinations often simplify and improve outcomes
  • We won’t oversell combinations vs licensed monotherapies

Honest framing about the two mechanisms

Understanding what each active does:

  • Azelaic acid: tyrosinase inhibition (blocks melanin production), antimicrobial, keratinisation, anti-inflammatory
  • Niacinamide: melanosome transfer inhibition (blocks pigment reaching surface), sebum regulation, barrier support, anti-inflammatory
  • The mechanisms genuinely complement rather than duplicate
  • Combined pigmentation coverage: production + transfer inhibition
  • Combined acne coverage: antimicrobial + sebum + keratinisation + barrier
  • Combined rosacea coverage: papule reduction + anti-inflammatory + barrier

Honest framing about pregnancy and combination products

Filling important gaps:

  • Pregnancy skincare options are genuinely limited
  • Retinoids are contraindicated
  • Hydroquinone is contraindicated
  • Higher-strength AHAs are usually avoided
  • Both actives in this combination are considered safe in pregnancy
  • So this combination fills a real gap for pregnancy acne, rosacea, or melasma

Honest framing about the compounded status

Being transparent about what this is:

  • The individual actives are well-established (azelaic acid licensed as Skinoren and Finacea, niacinamide widely OTC)
  • The specific combination is prepared as a compounded skincare preparation
  • This isn’t an experimental product — it combines well-known actives with strong evidence
  • If licensed monotherapies would suit you better, we’ll tell you
  • If OTC alternatives meet your needs, we’ll be honest about that

Skin concerns and the bigger picture

Skin concerns rarely sit in isolation. So our pharmacist can discuss:

  • Underlying causes: hormones, stress, diet, medication
  • Trigger identification for rosacea flares
  • Hormonal factors (PCOS, perimenopause) affecting adult acne
  • Sun exposure patterns and SPF habits
  • Skin type and Fitzpatrick classification
  • Nutrition and skin health
  • Sleep and skin repair cycles
  • Mental health impact of visible skin concerns
  • When to consider adding tretinoin from the Gro range
  • When to consider prescription options (hydroquinone, antibiotics, oral treatments)
  • When to consider procedural options
  • When specialist referral makes sense

Sometimes the visible concern is the visible part of a wider picture worth talking through.

Pharmacist support before and after supply

Our team is here to discuss:

  • Whether this combination fits your specific mix of concerns
  • Whether licensed monotherapies would suit you better
  • How to build a skincare routine around this product
  • How to manage the initial tingling phase
  • How to integrate with prescription retinoids if applicable
  • SPF recommendations for your skin type and goals
  • Realistic expectations for each of your concerns
  • Review at 3 months to assess response

Trust earned, not claimed

We are GPhC-regulated, and our content is grounded in published clinical literature on azelaic acid (Skinoren SmPC, Finacea SmPC, multiple clinical trials since the 1990s), the landmark Hakozaki 2002 study on niacinamide and melanosome transfer, subsequent clinical studies on both actives, British Association of Dermatologists guidance on acne, rosacea, and hyperpigmentation, NICE Clinical Knowledge Summaries on acne and rosacea, MHRA guidance on compounded preparations, and the real experience of patients managing multi-concern skin situations.

If this combination isn’t the right answer for your situation, we’ll tell you honestly. After all, getting the right treatment matters more than fulfilling a request.

How supply works

This is a pharmacy-compounded skincare preparation, so supply happens through consultation.

How our service works

  1. Complete the online consultation on courierpharmacy.co.uk
  2. Our UK-qualified pharmacist reviews your skin concerns and history
  3. Our pharmacist may request photos for baseline assessment
  4. Our pharmacist may ask follow-up questions about your specific mix of concerns
  5. If suitable, the pharmacist arranges compounding of your cream
  6. Your order is dispatched in plain, discreet packaging
  7. Free pharmacist support is available throughout use
  8. Review at 3 months to assess response

When other options might suit better

If this combination isn’t right, we’ll explain why. Other options may include:

  • Licensed Skinoren 20% cream — for pure acne focus
  • Licensed Finacea 15% gel — for pure rosacea focus
  • Niacinamide 3% cream alone (from the Gro range) — for gentler foundation approach
  • Tretinoin 0.025% cream (from the Gro range) — for stronger anti-aging or acne
  • OTC niacinamide serums — for cheaper foundation approach
  • Prescription antibiotic gels — for inflammatory acne needing faster action
  • Prescription hydroquinone — for stubborn or resistant pigmentation
  • Kligman’s formula — for advanced melasma
  • Oral acne therapy (antibiotics, spironolactone) — for resistant acne
  • Oral tranexamic acid — for stubborn melasma
  • Chemical peels — for surface pigmentation with faster results
  • Laser or light-based treatments — for pigmentation or rosacea vessels
  • Dermatology referral for complex or resistant cases

Our community service

Our free fortnightly drop-in clinics at Insomnia, Derby run every other week from 10am to 12pm.

Healthcare shouldn’t only happen when you’re paying for it. So we show up, even when it’s free.

We cover skincare, acne, rosacea, pigmentation, hair loss, dermatology, MCAS, weight management, menopause, women’s health, men’s health, chronic pain, digestive health, allergies, asthma, sleep, and whatever else people bring through the door. No appointment needed, no charge, no pressure.

Dr Ada Jex Cori at courierpharmacy.co.uk holding a coffee 2

Active ingredients

Each tube contains:

  • Azelaic acid 20% (200mg per gram) — dicarboxylic acid, tyrosinase inhibitor, antimicrobial
  • Niacinamide 4% (40mg per gram) — vitamin B3 derivative, melanosome transfer inhibitor
  • Emollient cream base with barrier-supporting properties

Why azelaic acid

Azelaic acid is one of the most versatile skincare actives:

  • A naturally occurring dicarboxylic acid produced by wheat, rye, and barley
  • Also produced by the yeast Malassezia furfur naturally present on skin
  • Licensed as Skinoren 20% cream (Bayer) for acne in the UK
  • Licensed as Finacea 15% gel (Leo Pharma) for papulopustular rosacea in the UK
  • Decades of clinical evidence for acne, rosacea, and pigmentation
  • Multiple mechanisms: tyrosinase inhibition, antimicrobial, keratinisation-normalising, anti-inflammatory
  • Well-tolerated with minimal photosensitivity
  • Suitable in pregnancy and breastfeeding
  • Works across all Fitzpatrick skin tones

In short, azelaic acid is one of the few actives with strong evidence across acne, rosacea, and pigmentation simultaneously. After all, when an active has three overlapping clinical uses with good tolerability, it earns its place in combination approaches.

Why the 20% strength for azelaic acid

The 20% strength is specifically chosen because it matches licensed evidence:

  • Matches the licensed strength in Skinoren cream (Bayer)
  • Based on decades of clinical trial evidence at this concentration
  • Higher than the 15% gel (Finacea) which is licensed specifically for rosacea
  • Higher than typical OTC azelaic acid concentrations (usually 5-10%)
  • Evidence-supported concentration for acne, rosacea, and pigmentation
  • Balance of efficacy and tolerability at the licensed strength

After all, matching the licensed strength means the clinical evidence applies directly. So this isn't an experimental concentration — it's the well-studied dose in combination form.

Why niacinamide

Niacinamide brings complementary mechanisms:

  • A form of vitamin B3 (nicotinamide)
  • Different from niacin (nicotinic acid) — doesn't cause flushing
  • Water-soluble and well-absorbed by skin
  • Landmark Hakozaki 2002 study showed 35-68% reduction in melanosome transfer
  • Multiple clinical trials for acne, pigmentation, and skin barrier
  • Works through mechanisms genuinely different from azelaic acid
  • Well-tolerated and safe long-term
  • Suitable in pregnancy and breastfeeding

In short, niacinamide adds pathways that azelaic acid doesn't cover. After all, combining transfer inhibition (niacinamide) with production inhibition (azelaic acid) covers more of the pigmentation pathway than either alone.

Why the 4% strength for niacinamide

The 4% strength is specifically chosen for combination use:

  • Matches the concentration used in the landmark Shalita 1995 acne study
  • Sits in the evidence-supported range for skincare use (2-5%)
  • Slightly higher than the 3% used in monotherapy pigmentation formulations
  • Complements azelaic acid without adding to potential tingling
  • Well-tolerated at this concentration
  • Suitable for daily long-term use

After all, the 4% strength matches the acne evidence base while providing meaningful pigmentation and barrier support. So it fits the multi-concern positioning of this combination.

Why the combination approach

The two actives work through genuinely different but complementary pathways:

  • Azelaic acid: inhibits tyrosinase, reducing new melanin production
  • Niacinamide: reduces melanosome transfer, so less pigment reaches visible skin layers
  • Azelaic acid: antimicrobial action against P. acnes bacteria
  • Niacinamide: sebum regulation reducing acne substrate over time
  • Azelaic acid: normalises keratinisation, reducing comedone formation
  • Niacinamide: skin barrier support and anti-inflammatory action
  • Together: broader coverage of acne, rosacea, and pigmentation pathways
  • Single application improves compliance vs two separate products

In short, treating multiple mechanisms with one product often gives better results than layering separate actives. So this combination fits patients wanting simpler routines with broader mechanism coverage.

Why the cream base

The base matters as much as the actives:

  • Emollient cream base with moisturising properties
  • Reduces the tingling that azelaic acid can cause in gel formulations
  • Supports skin barrier during treatment
  • Suitable for morning use under SPF
  • Suitable for evening use as a base layer or before other actives
  • Absorbs cleanly without pilling under other products
  • Better tolerated than azelaic acid gel formulations for many patients

After all, azelaic acid is more likely to cause tingling in gel form than in cream form. So the cream base makes the combination more sustainable for consistent daily use.

Other ingredients

The cream base contains standard emollient and stabilising excipients:

  • Versapro cream base
  • Ethoxy digycol
  • Propylene glycol

Specific excipients are listed on the individualised label. So mention any known allergies during your consultation.

Pack details

  • Tube designed to last approximately one to two months with facial use
  • Opaque container to protect from oxidation
  • Sealed for freshness on delivery
  • Individualised label with patient name, batch number, and expiry date
Dr Ada Jex Cori measuring active pharmaceutical ingredients on a weighing scale courierpharmacy.co.uk

What is this cream for?

This compounded combination cream is designed for patients whose skin concerns cross multiple categories — acne with pigmentation, rosacea with acne, pigmentation with sensitivity, or general uneven skin that involves several pathways. So instead of layering separate products for each concern, this combination addresses multiple mechanisms in a single application. As a result, it fits patients wanting simpler routines with broader mechanism coverage.

Who might this cream suit?

This product may suit:

  • Adults with mild-to-moderate acne alongside post-inflammatory hyperpigmentation
  • Adults with rosacea (particularly papulopustular and mixed types)
  • Adults with rosacea plus pigmentation concerns
  • Adults with post-inflammatory hyperpigmentation after acne
  • Adults with melasma looking for a well-tolerated dual-mechanism approach
  • Adults with darker skin tones prone to post-inflammatory hyperpigmentation from acne
  • Adults who couldn't tolerate tretinoin or hydroquinone
  • Adults wanting a single product for multiple concerns
  • Pregnant or breastfeeding women dealing with acne or pigmentation (both actives are pregnancy-safe)
  • Adults with sensitive skin needing effective but well-tolerated treatment
  • Adults preparing for or maintaining after procedural treatments (peels, laser)
  • Adults committed to daily SPF (essential for pigmentation results)

What this combination may help with

Based on clinical evidence for the individual actives:

  • Mild-to-moderate acne (comedonal and inflammatory)
  • Rosacea (papulopustular type — bumps and pustules)
  • Rosacea (erythematotelangiectatic type — redness and flushing)
  • Post-inflammatory hyperpigmentation after acne or inflammation
  • Mild-to-moderate melasma
  • Sun-induced pigmentation and uneven tone
  • Sebum regulation (less oily skin over time)
  • Skin barrier support
  • Reduced facial redness and background flushing
  • Antimicrobial action against acne bacteria
  • General skin clarity and texture improvements

Important honesty point: this is a versatile combination, but it's not the strongest option for any single concern. After all, hydroquinone works faster for severe pigmentation, tretinoin works better for advanced photoaging, and oral treatments fit severe acne. So this combination fits patients with mild-to-moderate multi-concern situations, not those needing single-concern intensive treatment.

What this cream doesn't claim to do

Honest framing matters:

  • It doesn't treat severe cystic or nodular acne (which usually needs prescription oral treatment)
  • It doesn't treat severe or resistant melasma (Kligman's formula or oral tranexamic acid fits better)
  • It doesn't treat rosacea flushing triggered by systemic factors alone
  • It doesn't cause dramatic anti-aging effects like tretinoin
  • It doesn't remove scars (only pigmentation and mild texture improve)
  • It doesn't work as fast as prescription-strength single-active approaches for specific concerns
  • It doesn't guarantee response — individual variation exists
  • It doesn't work without daily SPF for pigmentation goals
    Courierpharmacy.co.uk divider Dr Ada Jex Cori

How this combination works

Understanding the two mechanisms helps explain why this combination covers so many concerns.

How azelaic acid works

Azelaic acid acts through multiple pathways:

  1. Applied to the skin
  2. Absorbed through the outer skin layer
  3. Inhibits tyrosinase enzyme — the enzyme that converts tyrosine to melanin
  4. This reduces melanin production in hyperactive melanocytes
  5. Also has antimicrobial action against P. acnes bacteria
  6. Reduces the bacterial load contributing to acne inflammation
  7. Normalises keratinisation in pores
  8. Reduces comedone (blocked pore) formation
  9. Anti-inflammatory action reduces papules and pustules
  10. Scavenges reactive oxygen species (mild antioxidant)

In short, azelaic acid tackles acne bacteria, blocked pores, inflammation, and melanin production simultaneously. After all, this is why the same molecule is licensed for both acne and rosacea.

How niacinamide works

Niacinamide brings complementary mechanisms:

  1. Applied to the skin
  2. Absorbed through the outer skin layer
  3. Converted in skin cells to NAD+ and NADP+ (cellular energy molecules)
  4. Reduces melanosome transfer from melanocytes to keratinocytes by 35-68%
  5. Less pigment reaches visible skin layers
  6. Increases ceramide production in the outer skin layer
  7. Strengthens the skin barrier and reduces water loss
  8. Reduces inflammatory signalling (inhibits NF-?B pathway)
  9. Reduces sebum production over time
  10. Provides antioxidant support

In short, niacinamide supports skin barrier, regulates sebum, blocks pigment transfer, and reduces inflammation. After all, this makes it a genuinely broad-spectrum active.

Why the combination covers more ground

The mechanisms complement rather than overlap:

For pigmentation specifically

  • Azelaic acid stops melanin being made (production inhibition)
  • Niacinamide stops melanin reaching the surface (transfer inhibition)
  • Combined: covers two different steps of the pigmentation pathway
  • Result: better coverage than either mechanism alone

For acne specifically

  • Azelaic acid: antimicrobial + normalises pores + anti-inflammatory
  • Niacinamide: sebum regulation + anti-inflammatory + barrier support
  • Combined: multiple acne pathways addressed simultaneously
  • Result: broader acne coverage without adding antibiotic resistance concerns

For rosacea specifically

  • Azelaic acid: anti-inflammatory + reduces papules and pustules
  • Niacinamide: barrier support + anti-inflammatory
  • Combined: addresses both the visible symptoms and the sensitivity underneath
  • Result: often better tolerated than single-active rosacea treatments

Timeline of results

Realistic expectations by timepoint:

  • Weeks 1-2: initial tolerability adjustment (possible mild tingling that settles)
  • Weeks 2-4: skin barrier and hydration improving
  • Weeks 4-8: acne improvements starting to show
  • Weeks 6-8: rosacea redness starting to reduce
  • Weeks 8-12: meaningful acne improvement, continued rosacea benefit
  • Weeks 12-16: first visible pigmentation improvements
  • Weeks 16-24: meaningful pigmentation improvement
  • Beyond 24 weeks: continued fading of stubborn pigmentation, long-term maintenance

Why continuous use matters

This is ongoing skincare, not a course:

  • Both actives work while being applied
  • Stopping treatment allows concerns to gradually return
  • Acne recurs if underlying tendency remains
  • Rosacea returns to background level
  • Pigmentation slowly re-accumulates without protection
  • Consistent daily use maintains benefits long-term
  • Can be reduced to once-daily maintenance after initial improvement
Dr Ada Jex Cori at courierpharmacy.co.uk thinking and looking into the distance

How to use azelaic acid 20% + niacinamide 4% cream

Consistent daily application over months is what makes combination treatment work.

Building up gradually

Recommended especially for sensitive skin:

  • Week 1: apply once daily (evening usually best)
  • Week 2: continue once daily, assess tolerance
  • Week 3 onwards: increase to twice daily if tolerated
  • If tingling is severe, stay at once daily longer
  • Most patients tolerate twice daily by week 2-3

Standard application

  1. Cleanse your face gently
  2. Pat dry
  3. Wait a few minutes for skin to fully dry
  4. Apply a small amount of cream (about half a fingertip) to the face
  5. Focus on affected areas but treat the whole face for even results
  6. Extend to neck, chest, or affected body areas as directed
  7. Massage gently until absorbed
  8. Wait 2-3 minutes before applying next products
  9. Follow with SPF 30+ in the morning (essential for pigmentation)
  10. Follow with moisturiser in the evening if additional hydration needed

The initial tingling phase

Common but usually manageable:

  • Azelaic acid can cause mild tingling or warmth on application in first 2 weeks
  • This isn't damage — it's a normal initial response
  • Typically settles as skin adapts over 1-2 weeks
  • If severe, reduce to once daily or apply to slightly damp skin
  • If persistent beyond 4 weeks, discuss with pharmacist

The non-negotiable SPF partnership

For pigmentation goals:

  • Daily broad-spectrum SPF 30+ is essential
  • Reapply every 2-3 hours during sun exposure
  • Use even in winter and on cloudy days
  • Visible light also triggers pigmentation — consider tinted SPF with iron oxides
  • Without daily SPF, pigmentation results won't be visible
  • For acne and rosacea use, SPF is still important but less critical to results

Combining with other actives

This combination integrates with most skincare routines:

  • Tretinoin (from the Gro range): use morning + evening pattern (this combo AM, tretinoin PM)
  • Vitamin C: fine to combine (myth of niacinamide incompatibility largely debunked)
  • Hyaluronic acid: fine to layer
  • Peptides: fine to combine
  • Retinols: use on alternating days initially if tolerance is an issue
  • Benzoyl peroxide: space out or use on different days
  • AHAs/BHAs: space out or use on alternating days
  • Prescription hydroquinone: often combined short-term for stubborn pigmentation
  • Antibiotics: fine to combine, often complementary for acne

Building a full skincare routine

Suggested framework — personalise with pharmacist:

  • Morning: cleanse ? this combination cream ? moisturiser ? SPF 30+
  • Evening: cleanse ? this combination cream ? moisturiser (or tretinoin if using both)
  • Weekly: gentle chemical exfoliation if tolerated

Where to apply

  • Face — standard application area
  • Neck — often affected by rosacea, pigmentation, sun damage
  • Chest (décolletage) — often affected by acne, pigmentation, sun damage
  • Back — for back acne with pigmentation
  • Hands — for age spots and pigmentation
  • Any affected body area

Avoid these areas:

  • Directly in the eye area
  • Inside the mouth or nostrils
  • Broken or damaged skin
  • Active weeping eczema or dermatitis

If you miss a dose

  • Simply apply at the next scheduled time
  • Don't apply extra to compensate
  • Missing occasional doses won't affect long-term results
  • Consistency over weeks matters more than any individual application

Storage

  • Store at room temperature (below 25°C)
  • Keep away from direct sunlight
  • Replace cap securely after use
  • Keep out of sight and reach of children
  • Don't share with anyone else
  • Use by the expiry date on the individualised label
Dr Ada Jex Cori applying an emollient cream for dry skin courierpharmacy.co.uk

Warnings and precautions

Both actives have clean safety profiles. So the warnings section is relatively short — but the honest points still matter.

Don't use this cream if you

  • Have known allergy to azelaic acid, niacinamide, or vitamin B3
  • Have active weeping eczema or dermatitis on the application area
  • Have broken or damaged skin at the application site
  • Have active herpes simplex on the face

Use with care if you

  • Have very sensitive skin (start with once daily)
  • Have a history of contact dermatitis to skincare products
  • Have active severe rosacea flares (introduce gradually)
  • Are already using multiple prescription topical treatments
  • Have asthma (rare theoretical concerns with azelaic acid in some patients)

The initial tingling warning

A normal but sometimes uncomfortable phase:

  • Azelaic acid commonly causes mild tingling or warmth in first 2 weeks
  • This is a normal response, not damage
  • Usually settles as skin adapts
  • If persistent or uncomfortable, reduce frequency
  • Cream base reduces tingling compared to gel formulations

The pigmentation assessment warning

Not all dark patches are simple hyperpigmentation:

  • Melanoma can present as new or changing pigmentation — needs urgent assessment
  • Post-inflammatory pigmentation from unknown cause needs cause identification
  • Some medications cause drug-induced pigmentation
  • Endocrine conditions can cause pigmentation
  • Any new, changing, or unusual pigmentation needs medical review before topical treatment

Pregnancy and breastfeeding

Reassuring news:

  • Both azelaic acid and niacinamide are considered safe in pregnancy and breastfeeding
  • Particularly useful for pregnancy melasma or pregnancy acne
  • Safer alternative to tretinoin or hydroquinone during these periods
  • Discuss with prescriber if you have concerns

Sun protection is essential for pigmentation goals

  • Daily broad-spectrum SPF 30+ isn't optional for pigmentation results
  • Consider tinted SPF with iron oxides for visible light protection
  • Without SPF, new pigmentation outpaces treatment

Use in older adults

No special considerations:

  • Well-tolerated across all adult age groups
  • Pigmentation and rosacea often become more relevant with age
  • Compatible with other age-related skincare needs

Driving and machinery

This cream doesn't affect driving or operating machinery.

When to seek medical advice

  • New, changing, or unusual pigmentation
  • Severe or persistent skin reaction
  • Widespread rash or blistering
  • Signs of allergic reaction (swelling, difficulty breathing)
  • Severe worsening of rosacea or acne
  • Concern about response after 3 months of consistent use
Dr Ada Jex Cori holding a warning sign courierpharmacy.co.uk

Side effects

Both actives are well-tolerated. So most side effects are mild and typically transient.

Common side effects

  • Mild tingling or warmth on application in first 2 weeks (usually azelaic acid-related, settles)
  • Mild redness at application sites (usually settles)
  • Very occasional mild dryness

Less common side effects

  • Contact dermatitis (uncommon)
  • Peeling or flaking
  • Temporary changes in skin pigmentation (usually lightening — the intended effect)
  • Skin sensitivity to previously tolerated products

Rare side effects

  • Allergic reactions
  • Severe skin reactions
  • Worsening of atopic dermatitis

Very rare side effects

  • Severe allergic reactions
  • Widespread rash or blistering

Stop and seek medical help if

  • Severe allergic reaction develops (facial swelling, breathing difficulty)
  • Widespread rash or blistering develops
  • Severe skin reaction develops
  • Signs of skin infection develop

Yellow Card reporting

If you notice any side effects, please report them through the MHRA Yellow Card scheme at https://yellowcard.mhra.gov.uk/, or talk to our pharmacist.

  Courierpharmacy.co.uk divider Dr Ada Jex Cori

Drug interactions

Topical use means systemic drug interactions are essentially not a concern. Skincare product interactions matter more.

Skincare products fine to combine

  • Vitamin C serums (complementary tyrosinase inhibition, myth of niacinamide incompatibility largely debunked)
  • Retinoids (tretinoin, adapalene, retinol) — use on alternating times to reduce irritation
  • Alpha-arbutin, kojic acid (additional tyrosinase inhibition)
  • Tranexamic acid topical (multiple mechanisms)
  • Hyaluronic acid
  • Peptides
  • Ceramide products
  • SPF (essential daily companion)
  • Simple moisturisers

Skincare products to use with care

  • Benzoyl peroxide — space out or use on different days (can add irritation)
  • AHAs and BHAs — space out or use on alternating days initially
  • High-strength vitamin C (L-ascorbic acid) — introduce gradually if using at same time
  • Physical exfoliants — reduce during initial adjustment phase

Prescription treatments

  • Prescription tretinoin: often used together (this combination morning, tretinoin evening)
  • Prescription hydroquinone: often combined short-term for stubborn pigmentation
  • Prescription antibiotics: fine to combine, often complementary for acne
  • Oral acne treatments (spironolactone, antibiotics, isotretinoin): fine to combine
  • Oral tranexamic acid: complementary for melasma

Systemic medicines

Topical use has minimal systemic effects, so systemic drug interactions are essentially not a concern. However, mention any medicines to our pharmacist during consultation.

  Courierpharmacy.co.uk divider Dr Ada Jex Cori

Frequently asked questions

Dr Ada Jex Cori courierpharmacy.co.uk

How does the combination work?

Two actives, complementary mechanisms:

  • Azelaic acid: tyrosinase inhibition + antimicrobial + normalises pores
  • Niacinamide: melanosome transfer inhibition + sebum regulation + barrier support
  • Combined: covers acne, rosacea, and pigmentation pathways in one product

Is this the same as Skinoren?

Similar but different:

  • Skinoren is licensed 20% azelaic acid monotherapy by Bayer
  • This combines the same 20% azelaic acid with niacinamide 4%
  • Skinoren is licensed for acne
  • This combination covers acne, rosacea, and pigmentation
  • If Skinoren monotherapy would suit you better, we'll recommend it

Is this the same as Finacea?

Related but different:

  • Finacea is 15% azelaic acid gel licensed for rosacea
  • This uses 20% azelaic acid (higher strength) in cream base with niacinamide
  • Finacea is a gel — can be drying for some patients
  • This cream base is generally better tolerated
  • Cream base also reduces the tingling azelaic acid can cause

Will I get the tingling effect?

Some patients do:

  • Azelaic acid commonly causes mild tingling in first 2 weeks
  • This is normal, not damage
  • Usually settles as skin adapts
  • Cream base reduces tingling compared to gel formulations
  • If severe, reduce to once daily or apply to slightly damp skin

Can I use this for acne alone?

Yes:

  • Well-suited for mild-to-moderate acne
  • Both actives contribute to acne treatment
  • Antimicrobial azelaic acid + sebum regulation from niacinamide
  • Also helps prevent post-inflammatory pigmentation as acne heals

Can I use this for rosacea?

Yes, particularly papulopustular type:

  • Azelaic acid is licensed for papulopustular rosacea (as Finacea)
  • Niacinamide adds anti-inflammatory and barrier support
  • Cream base reduces potential irritation
  • Introduce gradually if you have active rosacea flares

Can I use this for melasma?

Yes, particularly for well-tolerated approach:

  • Combined mechanism covers production + transfer of melanin
  • Well-tolerated for long-term use (unlike hydroquinone)
  • Safe during pregnancy when melasma often flares
  • Daily SPF including iron oxides is essential for melasma
  • Severe melasma may need Kligman's formula in addition

Can I use this during pregnancy?

Yes — one of the key advantages:

  • Both azelaic acid and niacinamide are considered safe in pregnancy and breastfeeding
  • Fills the gap when tretinoin and hydroquinone can't be used
  • Useful for pregnancy acne and pregnancy melasma
  • Provides evidence-based skincare during these periods

Does it work on darker skin tones?

Yes — well-suited:

  • Both actives work across all Fitzpatrick skin tones
  • Well-tolerated by darker skin without triggering more post-inflammatory hyperpigmentation
  • Niacinamide's mechanism works regardless of skin tone
  • Azelaic acid's mild lightening effect works on hyperactive melanocytes without depigmenting normal skin

Do I need SPF with this cream?

Depends on your goals:

  • For pigmentation goals: daily SPF 30+ is non-negotiable
  • For acne or rosacea: SPF is still important but less critical to results
  • Neither active causes photosensitivity
  • SPF supports whatever the cream is trying to improve
  • Consider tinted SPF with iron oxides for pigmentation focus

Can I use this alongside tretinoin?

Yes — often a strong combination:

  • This combination morning, tretinoin evening — standard approach
  • Adds retinoid mechanism to the coverage
  • Niacinamide in this cream buffers tretinoin irritation
  • Combined action addresses more concerns simultaneously
  • Both this cream and tretinoin are in the Gro range

When will I see results?

Depends on the concern:

  • Skin barrier and hydration: 2-4 weeks
  • Acne improvements: 4-8 weeks
  • Rosacea redness: 8-12 weeks
  • Pigmentation improvements: 12-24 weeks
  • Meaningful improvement across concerns: 12-24 weeks with consistent use

Can I combine with prescription antibiotics for acne?

Yes, often complementary:

  • Topical clindamycin can be combined
  • Oral antibiotics fine to combine
  • Combined mechanisms often give faster acne results
  • Azelaic acid doesn't contribute to antibiotic resistance

Can I combine with hydroquinone for pigmentation?

Yes, under prescriber guidance:

  • Hydroquinone short-term for stubborn pigmentation, then this cream for maintenance
  • Or use hydroquinone at night, this cream morning during active treatment
  • Combined tyrosinase inhibition + transfer inhibition covers more pathways
  • Hydroquinone use should be limited to 3-6 month courses

Will it help with acne scars?

Depends on scar type:

  • Post-inflammatory hyperpigmentation (dark marks): meaningful improvement over months
  • Post-inflammatory erythema (red marks): mild improvement
  • Deeper indented scars: minimal impact — need procedural treatment
  • Best used as part of broader scar management

How should I store the cream?

  • Room temperature (below 25°C)
  • Away from direct sunlight
  • Cap on securely after use
  • Out of reach of children
  • Use within expiry date on individualised label

Is my packaging discreet?

  • Plain packaging with no mention of contents
  • Suitable for delivery to home or workplace

How do I order from Courier Pharmacy?

Complete the consultation on courierpharmacy.co.uk. Our pharmacist will review your skin concerns and arrange dispensing if suitable. Your order goes out in plain, discreet packaging with support available throughout your use.

More than a prescription: our community

Healthcare shouldn't only happen when you're paying for it.

Every fortnight we run free drop-in talks and clinics at Insomnia, Derby, from 10am to 12pm. So we show up, even when it's free.

Bring a question, bring a friend, bring a stack of bewildering letters from another clinic. We'll sit with you.

We cover skincare, acne, rosacea, pigmentation, hair loss, dermatology, MCAS, weight management, menopause, women's health, men's health, chronic pain, digestive health, allergies, asthma, sleep, and whatever else people bring through the door. No appointment. No cost. No pressure. Just real support and treatment that fits.

This page is for information only and isn't a substitute for personal medical advice. This cream is a pharmacy-compounded skincare preparation combining two well-established actives. Results build gradually — acne improvements at 4-8 weeks, rosacea improvements at 8-12 weeks, pigmentation improvements at 12-24 weeks with consistent use plus daily SPF 30+. Daily broad-spectrum SPF is essential for pigmentation results. Any new, changing, or unusual pigmentation needs medical review before topical treatment. Always discuss any new or worsening symptoms with our pharmacist, your GP, or seek urgent medical advice if symptoms are severe. Signs of severe allergic reaction (facial swelling, breathing difficulty, widespread rash) need immediate medical attention.

How this content was created

Written by the Courier Pharmacy editorial team and reviewed by a GPhC-registered pharmacist.

The content is grounded in the licensed Skinoren 20% cream Summary of Product Characteristics, the licensed Finacea 15% gel Summary of Product Characteristics, the landmark Hakozaki 2002 study on niacinamide reducing melanosome transfer by 35-68%, subsequent clinical studies on both azelaic acid and niacinamide for acne, rosacea, and pigmentation, British Association of Dermatologists guidance on acne, rosacea, and hyperpigmentation, NICE Clinical Knowledge Summaries on acne vulgaris and rosacea, MHRA guidance on compounded preparations, and the real experience of patients managing multi-concern skin situations under pharmacist-guided care. In addition, it draws on the real questions patients bring to our consultation pathway and drop-in clinics in Derby.

References

[1] Courier Pharmacy (2026) Skin hyperpigmentation: pathophysiology and treatments. Available at: https://courierpharmacy.co.uk/skin-hyperpigmentation-pathophysiology-and-treatments/ (Accessed: 4 July 2026)

[2] Courier Pharmacy. (n.d.) Niacinamide 3% topical cream. Available at: https://courierpharmacy.co.uk/product/niacinamide-3-topical-cream/ (Accessed: 5 July 2026).

[3] Courier Pharmacy. (n.d.) Tretinoin 0.025% topical cream. Available at: https://courierpharmacy.co.uk/product/tretinoin-0-025-topical-cream/ (Accessed: 5 July 2026).

Courierpharmacy.co.uk divider Dr Ada Jex Cori

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